SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4inf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 282
PHE A 229
LEU A 223
LEU A 185
LEU A 178
 None
 1.38A 1e7wA-4infA:
undetectable		 1e7wA-4infA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 THR A 216
GLY A 213
GLY A 211
GLY A 207
GLY A 240
 None
None
None
CL  A 402 ( 3.7A)
None
 0.76A 1n2xB-4infA:
undetectable		 1n2xB-4infA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 228
LEU A 178
PHE A 175
ILE A 157
PRO A 136
 None
 1.27A 1re7B-4infA:
undetectable		 1re7B-4infA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 7 ASP A 314
VAL A 291
GLY A 213
THR A 287
 CA  A 401 (-2.6A)
None
None
None
 0.60A 1t7iB-4infA:
undetectable		 1t7iB-4infA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 7 ASP A 314
VAL A 291
GLY A 213
THR A 287
 CA  A 401 (-2.6A)
None
None
None
 0.57A 1t7jB-4infA:
undetectable		 1t7jB-4infA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 285
ILE A 237
PHE A 229
GLY A 243
LEU A 250
 None
 1.27A 2lbdA-4infA:
undetectable		 2lbdA-4infA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A  47
ASP A  41
LEU A  66
HIS A 188
 OXD  A 407 (-4.5A)
None
None
CA  A 401 (-3.5A)
 1.25A 2qxsA-4infA:
undetectable		 2qxsA-4infA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A  47
ASP A  41
LEU A  66
HIS A 188
 OXD  A 407 (-4.5A)
None
None
CA  A 401 (-3.5A)
 1.24A 2qxsB-4infA:
undetectable		 2qxsB-4infA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A  47
GLY A  49
ALA A  52
PRO A  92
GLY A  93
 OXD  A 407 (-4.5A)
None
None
None
None
 1.14A 2vmyB-4infA:
undetectable		 2vmyB-4infA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 309
GLY A 240
GLY A 243
ILE A 297
ALA A 312
 None
 0.94A 2z0yA-4infA:
undetectable		 2z0yA-4infA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 MET A 310
THR A 287
ALA A 345
GLU A  19
THR A 130
 None
None
None
CA  A 401 (-3.3A)
None
 1.29A 3dl9B-4infA:
undetectable		 3dl9B-4infA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 192
THR A 191
GLY A 204
GLY A 207
LEU A 201
 None
None
None
CL  A 402 ( 3.7A)
None
 1.27A 3fzgA-4infA:
undetectable		 3fzgA-4infA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 6 GLU A 180
ARG A 141
ALA A 177
ALA A 140
 None
 0.99A 3ns1C-4infA:
undetectable		 3ns1C-4infA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 8 GLU A 180
ARG A 141
ALA A 177
ALA A 140
 None
 0.99A 3ns1L-4infA:
undetectable		 3ns1L-4infA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A  27
TYR A  31
ALA A 107
LEU A 106
ILE A 143
 None
 1.11A 3ozwB-4infA:
undetectable		 3ozwB-4infA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 11 MET A  34
GLY A  38
ASP A  37
VAL A  30
LEU A  97
 None
 1.08A 3v8vB-4infA:
undetectable		 3v8vB-4infA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 6 THR A 287
ASN A 288
GLY A 290
ASP A 314
 None
None
None
CA  A 401 (-2.6A)
 1.05A 3w9tE-4infA:
undetectable		 3w9tE-4infA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 GLU A  10
GLY A   9
TYR A  13
GLN A 342
 None
 1.33A 3w9tG-4infA:
undetectable		 3w9tG-4infA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 THR A  80
ILE A  82
GLU A  20
PHE A 341
 None
 1.03A 4ac9C-4infA:
undetectable		 4ac9C-4infA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 THR A  80
ILE A  82
GLU A  20
PHE A 341
 None
 1.04A 4acaC-4infA:
2.0		 4acaC-4infA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 5 THR A  80
ILE A  82
GLU A  20
PHE A 341
 None
 1.03A 4acbC-4infA:
undetectable		 4acbC-4infA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 159
TYR A 165
PRO A  92
 None
 0.97A 4kahA-4infA:
2.7		 4kahA-4infA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 159
TYR A 165
PRO A  92
 None
 0.97A 4kbeA-4infA:
undetectable		 4kbeA-4infA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A 146
ALA A 147
ILE A 126
PRO A 184
VAL A 181
 None
 1.08A 4l1aA-4infA:
undetectable		 4l1aA-4infA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 159
TYR A 165
PRO A  92
 None
 0.97A 4lbgB-4infA:
undetectable		 4lbgB-4infA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 SER A  91
GLY A  93
GLN A  95
ILE A 143
GLY A 129
 None
 0.94A 4r29D-4infA:
undetectable		 4r29D-4infA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		3 / 3 LYS A 274
LYS A 281
SER A 282
 None
 1.42A 5odiA-4infA:
1.5		 5odiA-4infA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		4 / 8 ILE A 276
VAL A 284
LEU A 220
THR A 216
 None
 0.74A 5og9A-4infA:
undetectable		 5og9A-4infA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A 155
THR A 216
ALA A 110
THR A  24
GLU A  19
 None
None
None
None
CA  A 401 (-3.3A)
 1.22A 5vcgA-4infA:
undetectable		 5vcgA-4infA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4inf METAL-DEPENDENT
HYDROLASE
(Novosphingobium
aromaticivorans) 		5 / 12 VAL A 309
LEU A 220
SER A 289
MET A 304
LEU A 280
 None
 1.20A 6b52A-4infA:
undetectable		 6b52A-4infA:
21.60