SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4inq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 919
ARG A 983
TYR A 980
THR A 726
 None
 1.33A 1ceaA-4inqA:
undetectable
1ceaB-4inqA:
undetectable		 1ceaA-4inqA:
10.35
1ceaB-4inqA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 741
TYR A 962
ASP A 919
ARG A 921
 None
 1.48A 2a3bB-4inqA:
undetectable		 2a3bB-4inqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 827
SER A 825
LEU A 794
SER A 824
ASP A 828
 None
 1.40A 2j2pB-4inqA:
undetectable
2j2pC-4inqA:
undetectable		 2j2pB-4inqA:
19.07
2j2pC-4inqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 713
ARG A 716
PRO A 667
 None
 0.99A 2wljA-4inqA:
undetectable		 2wljA-4inqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		5 / 12 SER A 703
LYS A 789
ASP A 758
THR A 688
PHE A 753
 None
 1.40A 3a25A-4inqA:
undetectable		 3a25A-4inqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 951
ASP A 925
GLN A 672
 None
 0.78A 3lcvB-4inqA:
undetectable		 3lcvB-4inqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 910
VAL A 627
ARG A 629
 None
 0.68A 3p73A-4inqA:
undetectable		 3p73A-4inqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 907
ILE A 910
ARG A 984
GLU A 728
 None
 0.72A 4zzcE-4inqA:
undetectable		 4zzcE-4inqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 916
TYR A 962
TRP A 940
PRO A 924
 None
 1.03A 5x2sI-4inqA:
undetectable
5x2sJ-4inqA:
undetectable
5x2sK-4inqA:
undetectable		 5x2sI-4inqA:
15.89
5x2sJ-4inqA:
15.87
5x2sK-4inqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 985
ARG A 983
GLU A 982
LYS A 978
 None
 1.24A 6an0A-4inqA:
undetectable		 6an0A-4inqA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 799
ASN A 780
LEU A 784
PHE A 700
 None
PIF  A1001 (-3.7A)
None
None
 1.26A 6ekuA-4inqA:
undetectable		 6ekuA-4inqA:
19.56