SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4inz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.93A 1ng8A-4inzA:
undetectable		 1ng8A-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.93A 1ng8B-4inzA:
undetectable		 1ng8B-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.90A 1nrmA-4inzA:
undetectable		 1nrmA-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.90A 1nrmB-4inzA:
undetectable		 1nrmB-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.92A 1nruA-4inzA:
undetectable		 1nruA-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.92A 1nruB-4inzA:
undetectable		 1nruB-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.86A 1nt5A-4inzA:
undetectable		 1nt5A-4inzA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 100
VAL A  94
TRP A  37
 None
 0.86A 1nt5B-4inzA:
undetectable		 1nt5B-4inzA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 12 LEU A 168
PRO A  31
TYR A 187
HIS A 271
GLN A 270
 None
 1.30A 1s9aB-4inzA:
undetectable		 1s9aB-4inzA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 6 THR A 241
GLN A 138
PHE A 128
ASN A 246
 None
None
PEG  A 302 ( 4.9A)
None
 1.16A 1tt0B-4inzA:
0.7		 1tt0B-4inzA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		6 / 12 LEU A  55
LEU A  75
GLY A 101
TYR A 202
ALA A 100
ALA A 119
 None
None
PEG  A 302 ( 3.9A)
None
None
None
 1.42A 2bm9D-4inzA:
2.2		 2bm9D-4inzA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 ASP A 183
TYR A 187
HIS A  39
HIS A 271
 None
 1.42A 2bytA-4inzA:
undetectable		 2bytA-4inzA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 ASP A 183
TYR A 187
HIS A  39
HIS A 271
 None
 1.41A 2bytD-4inzA:
undetectable		 2bytD-4inzA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 5 LEU A 222
ILE A  72
GLY A 103
HIS A 124
 None
 0.91A 2otfA-4inzA:
undetectable		 2otfA-4inzA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 PRO A  64
GLU A  71
TYR A  70
 None
 0.73A 2zmbA-4inzA:
undetectable		 2zmbA-4inzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 0.97A 3aicA-4inzA:
undetectable		 3aicA-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 1.00A 3aicB-4inzA:
undetectable		 3aicB-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 0.98A 3aicE-4inzA:
undetectable		 3aicE-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 0.95A 3aicF-4inzA:
undetectable		 3aicF-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 0.96A 3aicG-4inzA:
undetectable		 3aicG-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 LEU A  13
TRP A  37
TYR A  58
 None
 0.96A 3aicH-4inzA:
undetectable		 3aicH-4inzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ASN A   9
ASN A   7
GLU A  62
 None
 0.90A 3kpdC-4inzA:
undetectable		 3kpdC-4inzA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_A_AG2A1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 9 SER A 198
GLY A  66
SER A  69
ASP A  78
LEU A  13
 None
 1.46A 3n2oA-4inzA:
2.0
3n2oB-4inzA:
1.1		 3n2oA-4inzA:
19.91
3n2oB-4inzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 VAL A  51
LEU A  25
LEU A  23
ILE A   6
 None
 1.01A 3u5kB-4inzA:
undetectable		 3u5kB-4inzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 11 LEU A 117
ILE A  72
ILE A 102
VAL A  95
LEU A  27
 None
 0.98A 3w67A-4inzA:
undetectable		 3w67A-4inzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 12 LEU A 117
ILE A  72
ILE A 102
VAL A  95
LEU A  27
 None
 0.92A 3w67B-4inzA:
1.9		 3w67B-4inzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 12 LEU A 117
ILE A  72
ILE A 102
VAL A  95
LEU A  27
 None
 0.97A 3w68D-4inzA:
2.3		 3w68D-4inzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 5 VAL A  51
LEU A  25
LEU A  23
ILE A   6
 None
 0.87A 4a9jC-4inzA:
undetectable		 4a9jC-4inzA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		6 / 12 ASP A  97
TYR A 144
PHE A 148
LEU A 168
TYR A 203
HIS A 267
 PEG  A 302 ( 4.7A)
None
None
None
PEG  A 302 (-4.6A)
None
 0.70A 4j03A-4inzA:
32.3		 4j03A-4inzA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 ASP A  97
PRO A  31
ASP A  32
HIS A 267
 PEG  A 302 ( 4.7A)
None
None
None
 0.93A 4k7gB-4inzA:
undetectable		 4k7gB-4inzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 10 TRP A 104
ALA A 100
PHE A 120
THR A  92
ILE A 118
 None
 1.30A 4km0A-4inzA:
undetectable		 4km0A-4inzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 HIS A 124
VAL A 254
ILE A 233
ALA A 119
 None
 0.88A 4lv9B-4inzA:
undetectable		 4lv9B-4inzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 12 ASP A  32
SER A 266
GLY A  29
ASP A  97
ASP A 239
 None
None
None
PEG  A 302 ( 4.7A)
None
 1.34A 4pevB-4inzA:
4.6		 4pevB-4inzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		3 / 3 ALA A 141
TYR A 144
PRO A 123
 None
None
PEG  A 302 (-4.7A)
 0.73A 4zdyA-4inzA:
undetectable		 4zdyA-4inzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 6 ASP A  97
PRO A 172
TYR A 187
LEU A 179
 PEG  A 302 ( 4.7A)
None
None
None
 1.21A 5bmvB-4inzA:
2.8		 5bmvB-4inzA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 7 ALA A 268
VAL A 277
LYS A 273
HIS A 271
 None
 1.09A 5ecnA-4inzA:
undetectable		 5ecnA-4inzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 8 LEU A  93
LEU A  55
GLY A  99
ALA A 100
 None
 0.71A 5f1aA-4inzA:
undetectable		 5f1aA-4inzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		5 / 12 ALA A 186
TYR A 187
LEU A  55
ILE A  72
GLY A 103
 None
 1.12A 5fsaA-4inzA:
undetectable		 5fsaA-4inzA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 5 TRP A 235
ASN A 246
TRP A 104
LEU A 227
 None
 1.30A 5vkqA-4inzA:
0.0
5vkqB-4inzA:
0.0		 5vkqA-4inzA:
9.97
5vkqB-4inzA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 5 TRP A 235
ASN A 246
TRP A 104
LEU A 227
 None
 1.35A 5vkqB-4inzA:
undetectable
5vkqC-4inzA:
undetectable		 5vkqB-4inzA:
9.97
5vkqC-4inzA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4inz SOLUBLE EPOXIDE
HYDROLASE
(Bacillus
megaterium) 		4 / 5 TRP A 235
ASN A 246
TRP A 104
LEU A 227
 None
 1.33A 5vkqC-4inzA:
0.0
5vkqD-4inzA:
0.0		 5vkqC-4inzA:
9.97
5vkqD-4inzA:
9.97