SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4io1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 10 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.94A 1muiA-4io1A:
undetectable		 1muiA-4io1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.88A 1muiB-4io1A:
undetectable		 1muiB-4io1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 10 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.93A 2aquA-4io1A:
undetectable		 2aquA-4io1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 7 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.14A 2cmlA-4io1A:
undetectable		 2cmlA-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 8 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.05A 2cmlB-4io1A:
undetectable		 2cmlB-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 8 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.13A 2cmlC-4io1A:
undetectable		 2cmlC-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 8 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.09A 2cmlD-4io1A:
undetectable		 2cmlD-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 LEU A  41
ARG A 108
THR A  63
LEU A  66
 None
 1.04A 2dysA-4io1A:
undetectable
2dysJ-4io1A:
undetectable		 2dysA-4io1A:
18.13
2dysJ-4io1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 SER A  59
ASP A  61
SER A  58
VAL A  32
 None
 1.22A 2hdnI-4io1A:
undetectable
2hdnJ-4io1A:
undetectable
2hdnL-4io1A:
undetectable		 2hdnI-4io1A:
10.42
2hdnJ-4io1A:
23.44
2hdnL-4io1A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 SER A  58
VAL A  32
SER A  59
ASP A  61
 None
 1.09A 2hdnJ-4io1A:
undetectable
2hdnK-4io1A:
undetectable
2hdnL-4io1A:
undetectable		 2hdnJ-4io1A:
23.44
2hdnK-4io1A:
10.42
2hdnL-4io1A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 1.02A 2hs1A-4io1A:
undetectable		 2hs1A-4io1A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 PRO A 208
ILE A 203
ASN A  93
LEU A 132
 None
 1.13A 2wekB-4io1A:
2.2		 2wekB-4io1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 VAL A 199
THR A 200
ALA A 104
THR A 166
ILE A 167
 None
 1.22A 3a35B-4io1A:
undetectable		 3a35B-4io1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 LEU A  41
ARG A 108
THR A  63
LEU A  66
 None
 1.06A 3asnA-4io1A:
undetectable
3asnJ-4io1A:
undetectable		 3asnA-4io1A:
18.13
3asnJ-4io1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 6 LEU A  41
ARG A 108
THR A  63
LEU A  66
 None
 1.05A 3asoA-4io1A:
undetectable
3asoJ-4io1A:
undetectable		 3asoA-4io1A:
18.13
3asoJ-4io1A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		3 / 3 SER A  59
GLY A  33
GLY A  35
 None
None
PO4  A 306 ( 3.8A)
 0.51A 3bogA-4io1A:
undetectable
3bogC-4io1A:
undetectable		 3bogA-4io1A:
undetectable
3bogC-4io1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 202
GLY A 101
ILE A 139
LEU A  98
GLU A  91
 None
CL  A 301 (-3.4A)
None
None
None
 1.09A 3ckkA-4io1A:
undetectable		 3ckkA-4io1A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		3 / 3 ARG A 163
VAL A 199
THR A 107
 None
 0.85A 3cyxA-4io1A:
undetectable		 3cyxA-4io1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.98A 3d1xB-4io1A:
undetectable		 3d1xB-4io1A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 10 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.99A 3ekyA-4io1A:
undetectable		 3ekyA-4io1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 11 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.95A 3el1A-4io1A:
undetectable		 3el1A-4io1A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.89A 3mwsA-4io1A:
undetectable		 3mwsA-4io1A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 ILE A 123
ASP A 176
ILE A 174
ASP A  90
PHE A 135
 None
None
None
PO4  A 306 ( 4.8A)
None
 1.46A 3phaB-4io1A:
undetectable		 3phaB-4io1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 0.99A 3pwmA-4io1A:
undetectable		 3pwmA-4io1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 5 VAL A  74
VAL A  55
LYS A  65
LYS A  67
 None
 1.39A 3rv5A-4io1A:
undetectable
3rv5B-4io1A:
undetectable		 3rv5A-4io1A:
19.55
3rv5B-4io1A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 1.02A 4njvA-4io1A:
undetectable		 4njvA-4io1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		3 / 3 THR A 216
ASN A 220
SER A 219
 None
 0.74A 4tvtA-4io1A:
undetectable		 4tvtA-4io1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 202
GLY A 101
GLY A 102
ALA A 205
LEU A 132
 None
CL  A 301 (-3.4A)
CL  A 301 ( 4.7A)
None
None
 0.72A 5c0oF-4io1A:
2.8		 5c0oF-4io1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 8 GLY A 202
ARG A 163
ASP A 176
ASP A  90
 None
None
None
PO4  A 306 ( 4.8A)
 0.97A 5vlmB-4io1A:
undetectable		 5vlmB-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		4 / 8 ILE A 174
ARG A 163
VAL A 177
ASP A  90
 None
None
None
PO4  A 306 ( 4.8A)
 1.04A 5vlmF-4io1A:
undetectable		 5vlmF-4io1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Francisella
tularensis) 		5 / 12 GLY A 103
ALA A 104
GLY A 202
ILE A  99
ILE A 174
 CL  A 301 (-3.5A)
None
None
None
None
 1.04A 6dh3B-4io1A:
undetectable		 6dh3B-4io1A:
15.14