SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4io6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 8 LEU A  44
GLY A 208
LEU A 234
TYR A  40
 None
 0.93A 1jlbA-4io6A:
undetectable		 1jlbA-4io6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		5 / 11 LEU A 226
ILE A 225
ASN A 100
GLY A 208
LEU A 234
 None
None
CL  A 303 (-3.1A)
None
None
 1.41A 2bxeA-4io6A:
undetectable		 2bxeA-4io6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 8 VAL A  18
VAL A 187
ASN A 190
GLN A 163
 None
 1.14A 2ij7C-4io6A:
undetectable		 2ij7C-4io6A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		5 / 12 ILE A 209
LEU A   5
MET A  52
PHE A  54
ALA A  56
 None
 1.36A 2noaA-4io6A:
undetectable		 2noaA-4io6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		5 / 12 LEU A  60
PHE A  20
ILE A 225
VAL A  58
LEU A  42
 None
 1.07A 3gwxB-4io6A:
undetectable		 3gwxB-4io6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		3 / 3 ARG A  11
THR A  35
THR A  65
 None
 0.70A 3k2hB-4io6A:
undetectable		 3k2hB-4io6A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		3 / 3 SER A  17
ASP A  85
ASN A 105
 None
MET  A 301 (-4.7A)
MET  A 301 ( 4.9A)
 0.85A 3lsfB-4io6A:
27.5
3lsfE-4io6A:
27.7		 3lsfB-4io6A:
28.83
3lsfE-4io6A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		3 / 3 ASP A  85
ASN A 105
SER A  17
 MET  A 301 (-4.7A)
MET  A 301 ( 4.9A)
None
 0.80A 3lsfB-4io6A:
27.5
3lsfE-4io6A:
27.7		 3lsfB-4io6A:
28.83
3lsfE-4io6A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 7 ALA A  73
ALA A  82
ALA A  61
PRO A  62
 None
 0.78A 4du2A-4io6A:
undetectable		 4du2A-4io6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 7 ALA A  73
ALA A  82
ALA A  61
PRO A  62
 None
 0.79A 4du2B-4io6A:
undetectable		 4du2B-4io6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 8 VAL A  41
TYR A  40
VAL A  14
ILE A  15
 None
 0.84A 4jq1B-4io6A:
undetectable		 4jq1B-4io6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		5 / 11 ILE A 209
ASP A 222
LEU A 226
LEU A 234
ILE A 102
 None
 1.13A 4p66A-4io6A:
undetectable		 4p66A-4io6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		4 / 5 ASP A  85
ILE A 209
ASN A  64
TYR A  67
 MET  A 301 (-4.7A)
None
None
MET  A 301 (-3.1A)
 0.98A 6a93B-4io6A:
undetectable		 6a93B-4io6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4io6 AVGLUR1 LIGAND
BINDING DOMAIN
(Adineta
vaga) 		5 / 12 GLY A  84
ILE A 209
VAL A  41
LEU A  44
ILE A  45
 None
 1.06A 6ectA-4io6A:
undetectable		 6ectA-4io6A:
23.84