SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 338
ASP A 322
ASP A 344
 None
 0.75A 1sqfA-4iobA:
undetectable		 1sqfA-4iobA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 309
ILE A 360
THR A 305
LEU A 362
THR A 370
 None
 1.48A 1tw4A-4iobA:
undetectable		 1tw4A-4iobA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		4 / 8 THR A 370
GLY A 406
THR A 373
VAL A 306
 None
 0.85A 2a1hA-4iobA:
undetectable
2a1hB-4iobA:
undetectable		 2a1hA-4iobA:
18.75
2a1hB-4iobA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 285
ALA A 396
THR A 373
ARG A 409
LEU A 378
 None
 1.49A 3aobC-4iobA:
3.9		 3aobC-4iobA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		5 / 12 THR A 305
GLY A 303
ASN A 295
HIS A 300
ILE A 360
 None
None
None
TBU  A 501 (-4.1A)
None
 1.40A 4pooB-4iobA:
undetectable		 4pooB-4iobA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4iob DIGUANYLATE CYCLASE
TPBB
(Pseudomonas
aeruginosa) 		5 / 12 SER A 371
ASP A 289
ILE A 286
ILE A 314
SER A 355
 None
 1.32A 4uroB-4iobA:
undetectable		 4uroB-4iobA:
22.22