SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
(Homo
sapiens) 		5 / 12 VAL A 154
TRP A 137
THR A  98
ASP A  97
PHE A  70
 None
None
None
NAG  A 201 ( 3.7A)
None
 1.44A 2y00B-4iopA:
undetectable		 2y00B-4iopA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
(Homo
sapiens) 		5 / 12 VAL A 154
TRP A 137
THR A  98
ASP A  97
PHE A  70
 None
None
None
NAG  A 201 ( 3.7A)
None
 1.43A 2y01B-4iopA:
undetectable		 2y01B-4iopA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE A 140
ASN A 143
SER B 187
SER A 145
 None
 1.10A 2zw9B-4iopA:
undetectable		 2zw9B-4iopA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
(Homo
sapiens) 		3 / 3 VAL A  65
LYS A  68
HIS A 114
 None
 0.92A 3elzA-4iopA:
undetectable		 3elzA-4iopA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4iop KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2
(Homo
sapiens) 		4 / 7 ASN B 127
GLY B 177
ILE B 192
PHE B  92
 None
 0.77A 4ejjA-4iopB:
undetectable		 4ejjA-4iopB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4iop KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2
(Homo
sapiens) 		4 / 7 ASN B 127
GLY B 177
ILE B 192
PHE B  92
 None
 0.83A 4ejjD-4iopB:
undetectable		 4ejjD-4iopB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
(Homo
sapiens) 		4 / 7 ILE A 161
GLY A 159
PHE A  72
PHE A  85
 None
 0.88A 5hieA-4iopA:
undetectable		 5hieA-4iopA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4iop C-TYPE LECTIN DOMAIN
FAMILY 2 MEMBER A
KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY F MEMBER 2
(Homo
sapiens) 		4 / 4 ARG A 158
PHE A 160
LEU B 147
PRO B 158
 None
NAG  A 204 (-4.2A)
None
None
 1.47A 5uh6C-4iopA:
0.0		 5uh6C-4iopA:
7.63