SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		5 / 11 LEU A 708
ILE A 534
THR A 666
PRO A 673
GLU A 539
 None
 1.41A 3qelA-4ioxA:
2.2
3qelB-4ioxA:
undetectable		 3qelA-4ioxA:
21.67
3qelB-4ioxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 508
GLY A 522
VAL A 525
ALA A 555
ALA A 552
 None
None
None
None
PEG  A 802 ( 3.9A)
 1.02A 3sufD-4ioxA:
undetectable		 3sufD-4ioxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 8 PHE A 647
ALA A 482
LEU A 678
LEU A 681
 None
 0.91A 4ejgB-4ioxA:
undetectable		 4ejgB-4ioxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 7 PHE A 647
ALA A 482
LEU A 678
LEU A 681
 None
 0.91A 4ejgC-4ioxA:
undetectable		 4ejgC-4ioxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		5 / 12 ASP A 707
THR A 666
VAL A 712
ASP A 706
GLN A 680
 None
 1.46A 4njgB-4ioxA:
1.4		 4njgB-4ioxA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 581
TYR A 507
LEU A 718
PHE A 634
 None
 1.30A 4twdB-4ioxA:
undetectable
4twdC-4ioxA:
undetectable		 4twdB-4ioxA:
23.34
4twdC-4ioxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 581
TYR A 507
LEU A 718
PHE A 634
 None
 1.27A 4twdD-4ioxA:
undetectable
4twdE-4ioxA:
undetectable		 4twdD-4ioxA:
23.34
4twdE-4ioxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 7 GLU A 581
TYR A 507
LEU A 718
PHE A 634
 None
 1.22A 4twdF-4ioxA:
undetectable
4twdJ-4ioxA:
undetectable		 4twdF-4ioxA:
23.34
4twdJ-4ioxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 581
TYR A 507
LEU A 718
PHE A 634
 None
 1.26A 4twdF-4ioxA:
undetectable
4twdG-4ioxA:
undetectable		 4twdF-4ioxA:
23.34
4twdG-4ioxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 6 GLU A 581
TYR A 507
LEU A 718
PHE A 634
 None
 1.20A 4twdI-4ioxA:
undetectable
4twdJ-4ioxA:
undetectable		 4twdI-4ioxA:
23.34
4twdJ-4ioxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 7 LEU A 677
ARG A 485
THR A 479
LEU A 478
 None
 1.00A 5b1bA-4ioxA:
undetectable
5b1bJ-4ioxA:
undetectable		 5b1bA-4ioxA:
21.00
5b1bJ-4ioxA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 708
ILE A 534
THR A 666
PRO A 673
GLU A 539
 None
 1.40A 5ewjC-4ioxA:
undetectable
5ewjD-4ioxA:
undetectable		 5ewjC-4ioxA:
21.76
5ewjD-4ioxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 477
PRO A 476
PHE A 486
LYS A 480
PHE A 651
 None
 1.33A 5hgcA-4ioxA:
undetectable		 5hgcA-4ioxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		3 / 3 GLY A 522
LEU A 708
HIS A 540
 None
 0.68A 5u63A-4ioxA:
undetectable		 5u63A-4ioxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		3 / 3 GLY A 522
LEU A 708
HIS A 540
 None
 0.69A 5u63B-4ioxA:
undetectable		 5u63B-4ioxA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		4 / 8 PRO A 491
THR A 493
TYR A 529
PRO A 673
 PGE  A 801 (-4.0A)
None
None
None
 1.08A 5x2sI-4ioxA:
undetectable
5x2sJ-4ioxA:
undetectable
5x2sK-4ioxA:
undetectable		 5x2sI-4ioxA:
23.91
5x2sJ-4ioxA:
19.77
5x2sK-4ioxA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4iox TRIPARTITE TERMINASE
SUBUNIT UL15
(Human
alphaherpesvirus
1) 		3 / 3 SER A 705
HIS A 540
TYR A 676
 None
 0.95A 5y2tA-4ioxA:
undetectable		 5y2tA-4ioxA:
undetectable