SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ip3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 LEU A  28
LEU A  31
ASN A  32
LEU A  36
LEU A 159
 None
 1.45A 1sqnA-4ip3A:
undetectable		 1sqnA-4ip3A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 10 SER A 193
PHE A 197
TYR A  76
LEU A  74
GLY A 149
 None
 1.35A 2b8jB-4ip3A:
undetectable		 2b8jB-4ip3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 GLU A 113
VAL A 181
LEU A 169
PHE A 167
ARG A 121
 None
 0.87A 2jj8C-4ip3A:
undetectable		 2jj8C-4ip3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 ILE A 107
GLU A 113
VAL A 181
LEU A 169
ARG A 121
 None
 1.33A 2jj8C-4ip3A:
undetectable		 2jj8C-4ip3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 4ip3 ORF169B
(Shigella
flexneri) 		6 / 12 ILE A 107
GLU A 113
VAL A 181
LEU A 169
PHE A 167
ARG A 121
 None
 1.41A 2no0A-4ip3A:
undetectable		 2no0A-4ip3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 GLU A 113
VAL A 181
LEU A 169
PHE A 167
ARG A 121
 None
 1.05A 2no0B-4ip3A:
undetectable		 2no0B-4ip3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 ILE A 107
GLU A 113
VAL A 181
PHE A 167
ARG A 121
 None
 1.38A 2no0B-4ip3A:
undetectable		 2no0B-4ip3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ip3 ORF169B
(Shigella
flexneri) 		4 / 8 PHE A  94
TRP A 146
ALA A  66
LEU A  67
 None
 1.03A 2o01A-4ip3A:
undetectable		 2o01A-4ip3A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 LEU A  28
LEU A  31
ASN A  32
LEU A  36
LEU A 159
 None
 1.45A 2w8yB-4ip3A:
undetectable		 2w8yB-4ip3A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 LEU A  28
LEU A  31
ASN A  32
LEU A  36
LEU A 159
 None
 1.43A 3d90A-4ip3A:
undetectable		 3d90A-4ip3A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4ip3 ORF169B
(Shigella
flexneri) 		3 / 3 HIS A 199
SER A 193
GLU A 196
 None
 0.85A 3s8pA-4ip3A:
undetectable		 3s8pA-4ip3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ip3 ORF169B
(Shigella
flexneri) 		4 / 8 LEU A  28
THR A  48
LEU A  49
LEU A  45
 None
 0.79A 4z90F-4ip3A:
undetectable
4z90G-4ip3A:
undetectable
4z90H-4ip3A:
undetectable
4z90I-4ip3A:
undetectable
4z90J-4ip3A:
undetectable		 4z90F-4ip3A:
19.75
4z90G-4ip3A:
19.75
4z90H-4ip3A:
19.75
4z90I-4ip3A:
19.75
4z90J-4ip3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4ip3 ORF169B
(Shigella
flexneri) 		6 / 12 ALA A 143
MET A 137
ILE A 190
SER A 104
PHE A  94
GLY A  64
 None
 1.36A 5m24A-4ip3A:
undetectable		 5m24A-4ip3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 LEU A 127
GLY A 149
ALA A 123
VAL A 192
PHE A 197
 None
 1.25A 5x6yA-4ip3A:
undetectable		 5x6yA-4ip3A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 VAL A 181
PHE A 167
PHE A 158
ILE A 138
VAL A 189
 None
 1.10A 6ap6A-4ip3A:
undetectable		 6ap6A-4ip3A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4ip3 ORF169B
(Shigella
flexneri) 		5 / 12 VAL A 181
PHE A 167
PHE A 158
ILE A 138
VAL A 189
 None
 1.10A 6ap6B-4ip3A:
undetectable		 6ap6B-4ip3A:
19.71