SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ipa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 0.86A 1hrkA-4ipaA:
undetectable		 1hrkA-4ipaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 327
THR A 326
ALA A  82
GLY A 254
SER A 250
 None
 0.94A 1nbiC-4ipaA:
undetectable		 1nbiC-4ipaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 327
THR A 326
ALA A  82
GLY A 254
SER A 250
 None
 0.93A 1nbiD-4ipaA:
undetectable		 1nbiD-4ipaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 9 ARG A 336
GLY A 244
VAL A 245
GLU A 246
ILE A 341
 None
 1.45A 1pw7B-4ipaA:
undetectable		 1pw7B-4ipaA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER A  36
LEU A  38
ILE A  45
ILE A  48
 None
 0.80A 1sbrA-4ipaA:
undetectable		 1sbrA-4ipaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER A  36
LEU A  38
ILE A  48
THR A  77
 None
 0.95A 1sbrA-4ipaA:
undetectable		 1sbrA-4ipaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ARG A 336
GLY A 244
VAL A 245
GLU A 246
ILE A 341
 None
 1.41A 1vhwC-4ipaA:
undetectable
1vhwE-4ipaA:
undetectable		 1vhwC-4ipaA:
19.72
1vhwE-4ipaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ARG A 336
GLY A 244
VAL A 245
GLU A 246
ILE A 341
 None
 1.41A 1vhwA-4ipaA:
undetectable
1vhwD-4ipaA:
undetectable		 1vhwA-4ipaA:
19.72
1vhwD-4ipaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 0.83A 2pnjB-4ipaA:
undetectable		 2pnjB-4ipaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 147
PHE A 146
PHE A 362
LEU A 359
 None
 1.02A 3abkP-4ipaA:
undetectable
3abkW-4ipaA:
undetectable		 3abkP-4ipaA:
20.05
3abkW-4ipaA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 0.68A 3aqiA-4ipaA:
undetectable		 3aqiA-4ipaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 CYH A 249
SER A 250
ALA A 148
ASN A 202
ILE A 203
 None
 1.09A 3ddyA-4ipaA:
undetectable		 3ddyA-4ipaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU A 225
ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 1.46A 3hcpB-4ipaA:
undetectable		 3hcpB-4ipaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ARG A 336
GLY A 244
VAL A 245
GLU A 246
ILE A 341
 None
 1.34A 3uayA-4ipaA:
undetectable		 3uayA-4ipaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A  72
ASN A  70
ASP A 117
ILE A 116
ALA A  24
 None
 1.16A 4dx5B-4ipaA:
3.1		 4dx5B-4ipaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 191
LEU A 192
LEU A 225
ILE A 376
GLN A 379
 None
 1.22A 4f4dA-4ipaA:
undetectable		 4f4dA-4ipaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 TYR A 119
VAL A 242
ILE A 351
ALA A  24
 None
 0.66A 4lv9B-4ipaA:
undetectable		 4lv9B-4ipaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 9 LEU A 147
PHE A 362
THR A 126
ILE A 127
ASP A 125
 None
 1.35A 4pcuA-4ipaA:
undetectable
4pcuB-4ipaA:
undetectable		 4pcuA-4ipaA:
22.59
4pcuB-4ipaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A  72
ASN A  70
ASP A 117
ILE A 116
ALA A  24
 None
 1.15A 4u95B-4ipaA:
2.7		 4u95B-4ipaA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 138
GLU A 139
GLY A 140
THR A 149
LEU A 145
 None
 1.49A 5fhzD-4ipaA:
undetectable		 5fhzD-4ipaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 347
ILE A 348
THR A 340
GLY A 352
GLY A 353
 None
 0.91A 5koxA-4ipaA:
undetectable		 5koxA-4ipaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ILE A 138
PHE A 146
TRP A 357
ASP A 125
 None
 1.44A 5nr3A-4ipaA:
undetectable		 5nr3A-4ipaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		4 / 5 LEU A 147
PHE A 146
PHE A 362
LEU A 359
 None
 0.98A 5x1bP-4ipaA:
1.8		 5x1bP-4ipaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PRO A 107
ILE A 108
VAL A  79
THR A  78
ILE A 110
 None
 1.17A 6hlpA-4ipaA:
undetectable		 6hlpA-4ipaA:
20.25