SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ipe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 6 ALA A 695
SER A 488
ARG A 634
LEU A 697
 None
 1.20A 1gahA-4ipeA:
undetectable		 1gahA-4ipeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		3 / 3 ALA A 480
VAL A 475
TRP A 398
 None
 0.96A 1grmA-4ipeA:
undetectable		 1grmA-4ipeA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		3 / 3 ALA A 480
VAL A 475
TRP A 398
 None
 0.96A 1grmB-4ipeA:
undetectable		 1grmB-4ipeA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.42A 1kiaC-4ipeA:
undetectable		 1kiaC-4ipeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.43A 1kiaD-4ipeA:
undetectable		 1kiaD-4ipeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.42A 1nbhB-4ipeA:
undetectable		 1nbhB-4ipeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.42A 1nbhD-4ipeA:
undetectable		 1nbhD-4ipeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 ILE A 213
ILE A 158
LEU A 160
ILE A 128
ILE A 300
 None
 1.07A 1oipA-4ipeA:
2.0		 1oipA-4ipeA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 VAL A 614
THR A 615
ARG A 588
LYS A 588
 None
 1.11A 2kotA-4ipeA:
undetectable		 2kotA-4ipeA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		3 / 3 VAL A 126
GLU A 418
GLU A 123
 None
 0.71A 2nv4A-4ipeA:
undetectable		 2nv4A-4ipeA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 LEU A 270
ILE A 268
ASN A 134
PHE A 220
 None
None
MG  A 802 ( 2.5A)
None
 0.87A 2opxA-4ipeA:
undetectable		 2opxA-4ipeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 PHE A 636
THR A 610
VAL A 609
LEU A 657
ILE A 625
 None
 1.12A 2xrlA-4ipeA:
undetectable		 2xrlA-4ipeA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.21A 3dl9A-4ipeA:
undetectable		 3dl9A-4ipeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 LEU A 113
GLU A 255
GLY A 252
SER A 251
TRP A 246
 None
 1.25A 3ou6D-4ipeA:
undetectable		 3ou6D-4ipeA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 8 TYR A 381
LEU A 310
TYR A 332
PHE A 329
 None
 1.35A 3po7A-4ipeA:
undetectable		 3po7A-4ipeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 7 ASN A 690
GLU A 685
TYR A 688
ARG A 608
 None
 1.03A 4mi4B-4ipeA:
1.2
4mi4C-4ipeA:
undetectable		 4mi4B-4ipeA:
14.21
4mi4C-4ipeA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 8 ASN A 690
GLU A 685
TYR A 688
ARG A 608
 None
 1.02A 4mj8B-4ipeA:
undetectable
4mj8C-4ipeA:
undetectable		 4mj8B-4ipeA:
12.10
4mj8C-4ipeA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		3 / 3 PRO A 491
LEU A 490
GLN A 495
 None
 0.65A 4pevB-4ipeA:
undetectable		 4pevB-4ipeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 VAL A 288
ILE A 300
ILE A 158
PHE A 169
ILE A 213
 None
 1.05A 5hw8B-4ipeA:
undetectable
5hw8F-4ipeA:
undetectable
5hw8G-4ipeA:
undetectable		 5hw8B-4ipeA:
11.76
5hw8F-4ipeA:
11.76
5hw8G-4ipeA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		4 / 5 ARG A 464
PHE A 456
LEU A 482
LEU A 540
 None
 1.22A 5veuH-4ipeA:
undetectable		 5veuH-4ipeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio) 		5 / 12 THR A 470
THR A 469
VAL A 468
THR A 550
LEU A 483
 None
 1.48A 6ak3A-4ipeA:
undetectable		 6ak3A-4ipeA:
7.65