SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 LEU A 238
ILE A 225
TYR A 235
VAL A 272
 None
 1.09A 1db1A-4iqfA:
undetectable		 1db1A-4iqfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		5 / 9 SER A  13
SER A 170
ILE A 136
ILE A   2
GLY A  24
 None
 1.26A 3cv9A-4iqfA:
undetectable		 3cv9A-4iqfA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 ASP A  23
LEU A  20
ILE A 185
PRO A 182
 None
 1.17A 3s3vA-4iqfA:
undetectable		 3s3vA-4iqfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 ILE A  96
VAL A  31
LEU A  17
VAL A 181
ILE A  28
 None
 1.14A 3w68B-4iqfA:
undetectable		 3w68B-4iqfA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 ALA A  86
ILE A 136
LEU A 177
ASN A 106
 None
 0.85A 4g19A-4iqfA:
undetectable		 4g19A-4iqfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 PHE A 270
PRO A 287
GLN A 241
ALA A 239
GLY A 301
 None
 1.28A 4j7xA-4iqfA:
7.1		 4j7xA-4iqfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 PHE A 270
PRO A 287
GLN A 241
ALA A 239
GLY A 301
 None
 1.27A 4j7xB-4iqfA:
6.8		 4j7xB-4iqfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1322_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 GLU A 114
THR A 200
GLU A 127
LYS A 129
 None
None
PG5  A 401 (-4.8A)
None
 1.09A 4mghA-4iqfA:
0.0		 4mghA-4iqfA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4iqf METHIONYL-TRNA
FORMYLTRANSFERASE
(Bacillus
anthracis) 		4 / 7 GLN A  90
VAL A  92
PRO A  63
ILE A  83
 None
 0.93A 6cduF-4iqfA:
undetectable
6cduG-4iqfA:
undetectable		 6cduF-4iqfA:
23.20
6cduG-4iqfA:
23.20