SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_1
(MINERALOCORTICOID
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 12 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.39A 2ab2A-4iqgC:
undetectable		 2ab2A-4iqgC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 12 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.40A 2ab2B-4iqgC:
undetectable		 2ab2B-4iqgC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 12 GLY C  15
VAL C  91
ALA C  17
SER C 143
GLY C 188
 None
None
None
NAP  C 304 (-3.3A)
NAP  C 304 (-4.8A)
 1.07A 2vmyA-4iqgC:
3.4		 2vmyA-4iqgC:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		4 / 7 SER C 143
GLN C 153
ILE C 194
SER C 150
 NAP  C 304 (-3.3A)
None
NAP  C 304 (-3.2A)
FMT  C 301 (-3.1A)
 1.01A 2xz5A-4iqgC:
undetectable
2xz5B-4iqgC:
undetectable		 2xz5A-4iqgC:
21.13
2xz5B-4iqgC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		4 / 8 SER C 143
GLN C 153
ILE C 194
SER C 150
 NAP  C 304 (-3.3A)
None
NAP  C 304 (-3.2A)
FMT  C 301 (-3.1A)
 0.96A 2xz5B-4iqgC:
undetectable
2xz5E-4iqgC:
undetectable		 2xz5B-4iqgC:
21.13
2xz5E-4iqgC:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 10 ILE C 164
PHE C  71
ALA C  83
LEU C  84
ALA C 123
 None
 1.37A 3lw5B-4iqgC:
undetectable		 3lw5B-4iqgC:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		4 / 5 LEU C 118
GLY C 115
MET C  70
ASN C  32
 None
None
None
NAP  C 304 (-3.6A)
 1.21A 3uq6B-4iqgC:
2.9		 3uq6B-4iqgC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 12 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.40A 3vhuA-4iqgC:
undetectable		 3vhuA-4iqgC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		3 / 3 HIS C 195
GLY C 188
ILE C 189
 NAP  C 304 (-3.9A)
NAP  C 304 (-4.8A)
NAP  C 304 ( 4.7A)
 0.64A 4k50A-4iqgC:
undetectable		 4k50A-4iqgC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		3 / 3 HIS C 195
GLY C 188
ILE C 189
 NAP  C 304 (-3.9A)
NAP  C 304 (-4.8A)
NAP  C 304 ( 4.7A)
 0.62A 4k50I-4iqgC:
undetectable		 4k50I-4iqgC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		4 / 7 LEU C  21
SER C  18
ILE C 226
VAL C 139
 None
 1.13A 4tvtA-4iqgC:
undetectable		 4tvtA-4iqgC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 12 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.38A 4udaA-4iqgC:
undetectable		 4udaA-4iqgC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Polaromonas
sp.
JS666) 		5 / 11 ARG C  48
ALA C  23
ALA C  19
ILE C   7
VAL C   5
 None
 1.18A 5yk2A-4iqgC:
undetectable		 5yk2A-4iqgC:
22.20