SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DIT_P_2PPP1_1 (ALPHA-THROMBIN PEPTIDE INHIBITOR CVS995)	4iqh	DYSFERLIN (Homo sapiens)	4 / 6	LEU A 83 GLU A 75 ASP A 23 PRO A 24	None	1.16A	1ditH-4iqhA: undetectable 1ditP-4iqhA: undetectable	1ditH-4iqhA: 21.81 1ditP-4iqhA: 6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GAH_A_ACRA497_2 (GLUCOAMYLASE-471)	4iqh	DYSFERLIN (Homo sapiens)	4 / 6	ALA A 86 SER A 124 TRP A 48 LEU A 107	None	1.11A	1gahA-4iqhA: undetectable	1gahA-4iqhA: 13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXF_B_DZPB2001_1 (SERUM ALBUMIN)	4iqh	DYSFERLIN (Homo sapiens)	5 / 12	LEU A 94 PHE A 103 LEU A 67 VAL A 123 LEU A 3	None	1.34A	2bxfB-4iqhA: undetectable	2bxfB-4iqhA: 14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA504_0 (CHORISMATE SYNTHASE)	4iqh	DYSFERLIN (Homo sapiens)	4 / 5	SER A 22 ARG A 81 LEU A 13 SER A 15	None	1.34A	2qhfA-4iqhA: undetectable	2qhfA-4iqhA: 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH504_3 (PHOSPHOLIPASE A2)	4iqh	DYSFERLIN (Homo sapiens)	5 / 11	VAL A 8 LEU A 7 LYS A 87 PRO A 106 LYS A 112	None	1.21A	3bjwH-4iqhA: undetectable	3bjwH-4iqhA: 17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F5U_A_CQNA610_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	4iqh	DYSFERLIN (Homo sapiens)	5 / 10	VAL A 123 ALA A 101 LEU A 3 LEU A 61 LEU A 67	None	1.00A	6f5uA-4iqhA: undetectable 6f5uB-4iqhA: undetectable	6f5uA-4iqhA: 22.96 6f5uB-4iqhA: 15.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DIT_P_2PPP1_1","ALPHA-THROMBIN;PEPTIDE INHIBITOR CVS995","4iqh","DYSFERLIN","Homo sapiens",4,"LEU A  83;GLU A  75;ASP A  23;PRO A  24","None","1.16A","1ditH-4iqhA:undetectable;1ditP-4iqhA:undetectable","1ditH-4iqhA:21.81;1ditP-4iqhA:6.15"],["1GAH_A_ACRA497_2","GLUCOAMYLASE-471","4iqh","DYSFERLIN","Homo sapiens",4,"ALA A  86;SER A 124;TRP A  48;LEU A 107","None","1.11A","1gahA-4iqhA:undetectable","1gahA-4iqhA:13.80"],["2BXF_B_DZPB2001_1","SERUM ALBUMIN","4iqh","DYSFERLIN","Homo sapiens",5,"LEU A  94;PHE A 103;LEU A  67;VAL A 123;LEU A   3","None","1.34A","2bxfB-4iqhA:undetectable","2bxfB-4iqhA:14.98"],["2QHF_A_ACTA504_0","CHORISMATE SYNTHASE","4iqh","DYSFERLIN","Homo sapiens",4,"SER A  22;ARG A  81;LEU A  13;SER A  15","None","1.34A","2qhfA-4iqhA:undetectable","2qhfA-4iqhA:16.42"],["3BJW_H_SVRH504_3","PHOSPHOLIPASE A2","4iqh","DYSFERLIN","Homo sapiens",5,"VAL A   8;LEU A   7;LYS A  87;PRO A 106;LYS A 112","None","1.21A","3bjwH-4iqhA:undetectable","3bjwH-4iqhA:17.39"],["6F5U_A_CQNA610_1","ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1;ENVELOPE GLYCOPROTEIN","4iqh","DYSFERLIN","Homo sapiens",5,"VAL A 123;ALA A 101;LEU A   3;LEU A  61;LEU A  67","None","1.00A","6f5uA-4iqhA:undetectable;6f5uB-4iqhA:undetectable","6f5uA-4iqhA:22.96;6f5uB-4iqhA:15.79"]]