SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.90A 1axwA-4iqqA:
36.2		 1axwA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1axwA-4iqqA:
36.2		 1axwA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.89A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.05A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 LYS A  79
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.06A 1axwB-4iqqA:
36.3		 1axwB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.80A 1b02A-4iqqA:
31.7		 1b02A-4iqqA:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
LEU A 194
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.08A 1b02A-4iqqA:
31.7		 1b02A-4iqqA:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.77A 1hvyA-4iqqA:
12.9		 1hvyA-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.68A 1hvyA-4iqqA:
12.9		 1hvyA-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.80A 1hvyB-4iqqA:
42.2		 1hvyB-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.72A 1hvyB-4iqqA:
42.2		 1hvyB-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 11 GLU A  89
ILE A 110
ASN A 114
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.61A 1hvyC-4iqqA:
13.1		 1hvyC-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ILE A 110
TRP A 111
ASN A 114
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
 0.66A 1hvyC-4iqqA:
13.1		 1hvyC-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 0.84A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.73A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.70A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
PHE A 227
 None
D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
 0.94A 1hvyD-4iqqA:
42.3		 1hvyD-4iqqA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		8 / 9 GLU A  89
ILE A 110
TRP A 111
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.42A 1i00A-4iqqA:
42.1		 1i00A-4iqqA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.29A 1i00B-4iqqA:
12.8		 1i00B-4iqqA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.03A 1ju6A-4iqqA:
41.7		 1ju6A-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.91A 1ju6A-4iqqA:
41.7		 1ju6A-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.75A 1ju6B-4iqqA:
41.8		 1ju6B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.04A 1ju6C-4iqqA:
41.8		 1ju6C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.91A 1ju6C-4iqqA:
41.8		 1ju6C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.76A 1ju6D-4iqqA:
41.8		 1ju6D-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujA-4iqqA:
41.3		 1jujA-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujB-4iqqA:
41.3		 1jujB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujC-4iqqA:
41.3		 1jujC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.16A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 10 LYS A  79
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.91A 1jujD-4iqqA:
41.3		 1jujD-4iqqA:
62.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LEU A  68
GLY A 233
LEU A  90
LEU A 163
MET A 181
 None
 1.17A 1mx1E-4iqqA:
undetectable		 1mx1E-4iqqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		4 / 7 THR A 253
ASN A 228
TYR A 232
LEU A 250
 None
UMP  A 401 (-3.3A)
None
None
 1.12A 1qzrA-4iqqA:
undetectable		 1qzrA-4iqqA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		4 / 7 THR A 253
ASN A 228
TYR A 232
LEU A 250
 None
UMP  A 401 (-3.3A)
None
None
 1.10A 1qzrB-4iqqA:
undetectable		 1qzrB-4iqqA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 1rtsA-4iqqA:
42.7		 1rtsA-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.30A 1rtsB-4iqqA:
43.2		 1rtsB-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 1tlsA-4iqqA:
36.2		 1tlsA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
 1.14A 1tlsA-4iqqA:
36.2		 1tlsA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.14A 1tlsB-4iqqA:
36.3		 1tlsB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.86A 1tlsB-4iqqA:
36.3		 1tlsB-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 1tsnA-4iqqA:
36.1		 1tsnA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.10A 1tsnA-4iqqA:
36.1		 1tsnA-4iqqA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.22A 2tsrA-4iqqA:
43.0		 2tsrA-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.33A 2tsrC-4iqqA:
42.9		 2tsrC-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.19A 2tsrD-4iqqA:
12.9		 2tsrD-4iqqA:
63.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.98A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.86A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.92A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.11A 3k2hA-4iqqA:
12.4		 3k2hA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.97A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.87A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.88A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.10A 3k2hB-4iqqA:
13.0		 3k2hB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.86A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.71A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.21A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.01A 3nrrA-4iqqA:
14.7		 3nrrA-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
ASN A 114
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.84A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.21A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.02A 3nrrB-4iqqA:
14.8		 3nrrB-4iqqA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
HIS A 198
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.74A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 1.07A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
LEU A 194
HIS A 198
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.77A 3uwlB-4iqqA:
35.8		 3uwlB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 HIS A 198
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.83A 3uwlD-4iqqA:
35.0		 3uwlD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 TRP A 111
LEU A 194
HIS A 198
LEU A 223
GLY A 224
ASN A 228
 None
None
UMP  A 401 ( 4.7A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.78A 3uwlD-4iqqA:
35.0		 3uwlD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.42A 4eb4A-4iqqA:
41.6		 4eb4A-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.46A 4eb4B-4iqqA:
41.7		 4eb4B-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.26A 4eb4C-4iqqA:
42.6		 4eb4C-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.23A 4eb4D-4iqqA:
42.8		 4eb4D-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
LEU A 194
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.16A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 194
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.08A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 LYS A  79
ILE A 110
LEU A 194
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.15A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 LYS A  79
ILE A 110
TRP A 111
LEU A 194
GLY A 224
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
None
None
D16  A 402 ( 3.1A)
 1.03A 4fogA-4iqqA:
36.2		 4fogA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 11 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 4fogD-4iqqA:
36.0		 4fogD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.06A 4fogD-4iqqA:
36.0		 4fogD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.80A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.90A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.95A 4foxA-4iqqA:
36.2		 4foxA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.66A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.80A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.04A 4foxB-4iqqA:
36.3		 4foxB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.70A 4foxC-4iqqA:
36.1		 4foxC-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.74A 4foxD-4iqqA:
35.9		 4foxD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.94A 4foxD-4iqqA:
35.9		 4foxD-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.61A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.62A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.99A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LYS A  79
GLU A  89
ILE A 110
GLY A 224
TYR A 260
 D16  A 402 ( 4.5A)
None
D16  A 402 (-4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 1.00A 4foxE-4iqqA:
36.5		 4foxE-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLU A  89
ILE A 110
ASP A 220
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.71A 4foxF-4iqqA:
36.1		 4foxF-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.74A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 194
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.86A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.89A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.00A 4foxG-4iqqA:
36.3		 4foxG-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 110
ASP A 220
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.94A 4foxH-4iqqA:
36.0		 4foxH-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.82A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.85A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.05A 4fqsA-4iqqA:
35.9		 4fqsA-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.84A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.85A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.87A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.06A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
 1.22A 4fqsB-4iqqA:
35.8		 4fqsB-4iqqA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		4 / 7 SER A 231
TYR A 232
PHE A  93
GLU A  89
 None
 1.43A 4xzkA-4iqqA:
undetectable		 4xzkA-4iqqA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 LYS A  79
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 1.18A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 VAL A  81
ILE A 110
CYH A 197
LEU A 223
TYR A 260
 None
D16  A 402 (-4.0A)
UMP  A 401 (-3.3A)
D16  A 402 (-3.7A)
D16  A 402 ( 4.2A)
 0.84A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 VAL A  81
ILE A 110
TRP A 111
LEU A 194
LEU A 223
 None
D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
 0.92A 5fctB-4iqqA:
42.3		 5fctB-4iqqA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 7 ILE A 110
ASP A 220
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.19A 5h3aA-4iqqA:
42.4		 5h3aA-4iqqA:
58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.26A 5h3aB-4iqqA:
12.7		 5h3aB-4iqqA:
58.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 HIS A 252
GLN A 216
LEU A 250
LEU A 229
 None
UMP  A 401 (-4.4A)
None
None
 1.15A 5hs6A-4iqqA:
undetectable		 5hs6A-4iqqA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
LEU A 223
GLY A 224
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.86A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
ILE A 110
TRP A 111
LEU A 223
GLY A 224
 None
D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.76A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLU A  89
TRP A 111
LEU A 194
LEU A 223
GLY A 224
 None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
 0.87A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.88A 5j7wD-4iqqA:
35.3		 5j7wD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 7 TYR A  82
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.15A 5nooA-4iqqA:
47.3		 5nooA-4iqqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 7 TYR A  82
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.28A 5nooB-4iqqA:
46.2		 5nooB-4iqqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 6 TYR A  82
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-3.6A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.16A 5nooC-4iqqA:
13.5		 5nooC-4iqqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 LEU A  76
LEU A  75
TRP A  83
 None
 0.83A 5nwuA-4iqqA:
undetectable		 5nwuA-4iqqA:
8.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLU A  89
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 None
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.38A 5x5qB-4iqqA:
42.7		 5x5qB-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 7 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.23A 5x5qC-4iqqA:
42.8		 5x5qC-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 5x5qD-4iqqA:
13.0		 5x5qD-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 6 ILE A 110
ASP A 220
LEU A 223
GLY A 224
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 ( 4.2A)
 0.24A 5x5qE-4iqqA:
42.7		 5x5qE-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 8 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.24A 5x5qF-4iqqA:
42.6		 5x5qF-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 220
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.79A 5x66A-4iqqA:
43.3
5x66B-4iqqA:
13.2		 5x66A-4iqqA:
62.54
5x66B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASP A 220
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.38A 5x66A-4iqqA:
43.3
5x66B-4iqqA:
13.2		 5x66A-4iqqA:
62.54
5x66B-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 9 ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.61A 5x66C-4iqqA:
43.1		 5x66C-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
ASP A 220
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.39A 5x66D-4iqqA:
42.9		 5x66D-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 LYS A  79
ILE A 110
ASP A 220
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 ( 4.5A)
D16  A 402 (-4.0A)
D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 0.93A 5x66F-4iqqA:
42.9		 5x66F-4iqqA:
62.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 1.08A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.13A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.83A 6qxsB-4iqqA:
35.0		 6qxsB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
D16  A 402 ( 4.2A)
 1.09A 6qyaB-4iqqA:
34.6		 6qyaB-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
HIS A 198
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.57A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
HIS A 198
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.49A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TRP A 111
LEU A 194
HIS A 198
GLY A 224
ASN A 228
 None
None
UMP  A 401 ( 4.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.61A 6qyaD-4iqqA:
34.6		 6qyaD-4iqqA:
43.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 220
LEU A 223
GLY A 224
ASN A 228
TYR A 260
 D16  A 402 ( 4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.76A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
TYR A 260
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
D16  A 402 ( 4.2A)
 0.97A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.18A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.24A 6r2eA-4iqqA:
41.7		 6r2eA-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.91A 6r2eB-4iqqA:
41.4		 6r2eB-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 1.03A 6r2eB-4iqqA:
41.4		 6r2eB-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.94A 6r2eC-4iqqA:
41.7		 6r2eC-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 10 ILE A 110
TRP A 111
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 1.04A 6r2eC-4iqqA:
41.7		 6r2eC-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 10 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.93A 6r2eD-4iqqA:
41.5		 6r2eD-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ASN A 114
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.10A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
ASN A 114
TYR A 137
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.83A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 0.97A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
ASN A 114
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.09A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
ASN A 114
TYR A 137
LEU A 194
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
None
UMP  A 401 (-3.3A)
 0.74A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
TRP A 111
LEU A 223
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
D16  A 402 (-3.7A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.17A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TRP A 111
TYR A 137
LEU A 194
LEU A 223
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
UMP  A 401 (-3.3A)
 0.90A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 110
TYR A 137
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.90A 6r2eE-4iqqA:
41.6		 6r2eE-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.95A 6r2eF-4iqqA:
41.5		 6r2eF-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.98A 6r2eG-4iqqA:
41.5		 6r2eG-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 11 ILE A 110
TRP A 111
ASN A 114
LEU A 223
GLY A 224
PHE A 227
ASN A 228
 D16  A 402 (-4.0A)
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
D16  A 402 (-3.2A)
UMP  A 401 (-3.3A)
 1.13A 6r2eG-4iqqA:
41.5		 6r2eG-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
ASN A 114
TYR A 137
LEU A 194
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
None
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.89A 6r2eH-4iqqA:
41.5		 6r2eH-4iqqA:
60.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4iqq THYMIDYLATE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 ILE A 110
TRP A 111
TYR A 137
LEU A 194
LEU A 223
GLY A 224
ASN A 228
 D16  A 402 (-4.0A)
None
None
None
D16  A 402 (-3.7A)
D16  A 402 ( 3.1A)
UMP  A 401 (-3.3A)
 0.99A 6r2eH-4iqqA:
41.5		 6r2eH-4iqqA:
60.43