SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 8 CYH A  54
ASP A  56
CYH A  68
GLY A  70
 ZN  A 402 (-2.1A)
None
ZN  A 402 (-2.4A)
None
 0.78A 1ekjA-4iqrA:
undetectable
1ekjB-4iqrA:
undetectable		 1ekjA-4iqrA:
18.77
1ekjB-4iqrA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 8 CYH A  54
ASP A  56
CYH A  68
GLY A  70
 ZN  A 402 (-2.1A)
None
ZN  A 402 (-2.4A)
None
 0.77A 1ekjG-4iqrA:
undetectable
1ekjH-4iqrA:
undetectable		 1ekjG-4iqrA:
18.77
1ekjH-4iqrA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		3 / 3 PHE A 285
TRP A 192
GLU A 150
 None
 0.95A 1mogA-4iqrA:
undetectable		 1mogA-4iqrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 401 ( 4.8A)
None
None
None
None
 0.90A 1qhsA-4iqrA:
undetectable		 1qhsA-4iqrA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 SER A 256
VAL A 178
ILE A 175
ILE A 349
ILE A 346
 MYR  A 401 ( 4.8A)
None
None
None
None
 0.93A 1qhyA-4iqrA:
undetectable		 1qhyA-4iqrA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 259
 None
None
MYR  A 401 ( 3.7A)
None
None
 0.91A 2rkgB-4iqrA:
undetectable		 2rkgB-4iqrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 211
ALA A 209
LEU A 293
LEU A 202
PHE A 285
 None
 1.09A 2w9gA-4iqrA:
undetectable		 2w9gA-4iqrA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 211
ALA A 209
LEU A 293
LEU A 202
PHE A 285
 None
 1.04A 2w9hA-4iqrA:
undetectable		 2w9hA-4iqrA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 8 LEU A 332
ILE A 284
HIS A 214
GLY A 216
 None
 0.92A 3b9lA-4iqrA:
undetectable		 3b9lA-4iqrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.29A 3bexC-4iqrA:
undetectable
3bexD-4iqrA:
undetectable		 3bexC-4iqrA:
21.63
3bexD-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.29A 3bexE-4iqrA:
undetectable
3bexF-4iqrA:
undetectable		 3bexE-4iqrA:
21.63
3bexF-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.30A 3bf1A-4iqrA:
undetectable
3bf1B-4iqrA:
undetectable		 3bf1A-4iqrA:
21.63
3bf1B-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.33A 3bf1C-4iqrA:
undetectable
3bf1D-4iqrA:
undetectable		 3bf1C-4iqrA:
21.63
3bf1D-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.29A 3bf1C-4iqrA:
undetectable
3bf1D-4iqrA:
undetectable		 3bf1C-4iqrA:
21.63
3bf1D-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 ARG A 258
ILE A 338
THR A 224
LEU A 263
THR A 334
 None
 1.29A 3bf1E-4iqrA:
undetectable
3bf1F-4iqrA:
undetectable		 3bf1E-4iqrA:
21.63
3bf1F-4iqrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 THR A 224
LEU A 263
THR A 334
ARG A 258
ILE A 338
 None
 1.32A 3bf1E-4iqrA:
undetectable
3bf1F-4iqrA:
undetectable		 3bf1E-4iqrA:
21.63
3bf1F-4iqrA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 CYH A 179
GLN A 185
LEU A 219
ARG A 226
LEU A 236
 None
MYR  A 401 (-4.8A)
MYR  A 401 ( 4.4A)
MYR  A 401 (-3.8A)
MYR  A 401 (-3.8A)
 0.92A 3fc6C-4iqrA:
23.2		 3fc6C-4iqrA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 11 LEU A 211
ALA A 209
LEU A 293
LEU A 202
PHE A 285
 None
 1.04A 3frbX-4iqrA:
undetectable		 3frbX-4iqrA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 7 ALA A 173
LEU A 236
LEU A 235
ILE A 172
 None
MYR  A 401 (-3.8A)
None
None
 0.71A 4ubsA-4iqrA:
undetectable		 4ubsA-4iqrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		3 / 3 VAL A 306
TYR A 279
ALA A 282
 None
 0.57A 4ybnA-4iqrA:
undetectable		 4ybnA-4iqrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		6 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 338
ILE A 259
 None
None
MYR  A 401 ( 3.7A)
None
None
None
 1.03A 5e5jA-4iqrA:
undetectable		 5e5jA-4iqrA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		3 / 3 LEU A 186
LEU A 189
TRP A 192
 None
 0.80A 5nwuA-4iqrA:
undetectable		 5nwuA-4iqrA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		5 / 12 LEU A 263
GLY A 222
ALA A 223
VAL A 178
ILE A 259
 None
None
MYR  A 401 ( 3.7A)
None
None
 0.90A 5t8hB-4iqrA:
undetectable		 5t8hB-4iqrA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens) 		4 / 6 LEU A 329
TYR A 319
ASP A 273
GLU A 276
 None
 1.24A 6djzC-4iqrA:
undetectable		 6djzC-4iqrA:
21.68