SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 4 ASP A 208
THR A 118
VAL A 202
SER A 121
 None
None
IOD  A 303 ( 4.2A)
NA  A 317 ( 4.2A)
 1.24A 3wxoA-4iqzA:
undetectable		 3wxoA-4iqzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		5 / 9 ASP A  96
ILE A  47
GLY A  97
VAL A  41
GLY A  45
 None
None
None
None
IOD  A 302 ( 4.0A)
 1.28A 4acaB-4iqzA:
undetectable
4acaC-4iqzA:
undetectable		 4acaB-4iqzA:
23.16
4acaC-4iqzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8A-4iqzA:
undetectable		 5hm8A-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8B-4iqzA:
undetectable		 5hm8B-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8C-4iqzA:
undetectable		 5hm8C-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 0.99A 5hm8D-4iqzA:
undetectable		 5hm8D-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8E-4iqzA:
undetectable		 5hm8E-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 0.99A 5hm8F-4iqzA:
undetectable		 5hm8F-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8G-4iqzA:
undetectable		 5hm8G-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		4 / 5 GLU A  82
GLU A  70
THR A  69
LEU A  92
 None
IOD  A 309 (-3.7A)
None
None
 1.00A 5hm8H-4iqzA:
undetectable		 5hm8H-4iqzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4iqz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'
(Escherichia
coli) 		5 / 12 LEU A 198
LEU A 190
ALA A 211
ALA A 166
ILE A 169
 None
 1.09A 5nm5B-4iqzA:
undetectable		 5nm5B-4iqzA:
19.87