SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ir8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 SER A  87
GLU A  88
GLU A  89
 None
 0.35A 1eqbD-4ir8A:
undetectable		 1eqbD-4ir8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 SER A  87
GLU A  88
GLU A  89
 None
 0.34A 1eqbB-4ir8A:
undetectable		 1eqbB-4ir8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		6 / 12 ASP A 184
GLY A 197
VAL A 167
GLY A 180
ILE A 200
VAL A 166
 None
 1.50A 1k6cB-4ir8A:
undetectable		 1k6cB-4ir8A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 4 HIS A 132
VAL A 152
THR A  22
LEU A  14
 None
 1.46A 1oq5A-4ir8A:
undetectable		 1oq5A-4ir8A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ALA A 277
LEU A 280
ALA A 279
THR A 289
GLN A 253
 None
 1.03A 2jjpA-4ir8A:
undetectable		 2jjpA-4ir8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 7 SER A 126
CYH A 105
GLN A 150
ILE A 103
 None
 1.27A 2xz5A-4ir8A:
undetectable
2xz5B-4ir8A:
undetectable		 2xz5A-4ir8A:
19.71
2xz5B-4ir8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 ASP A 218
SER A 262
ARG A 214
 None
 0.95A 3loqA-4ir8A:
undetectable		 3loqA-4ir8A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 5 ALA A 221
PRO A 220
TYR A 222
ALA A 215
 None
 1.42A 3twpD-4ir8A:
undetectable		 3twpD-4ir8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 5 LEU A  23
LEU A  26
LEU A 155
SER A 154
 None
 0.97A 3vhuA-4ir8A:
undetectable		 3vhuA-4ir8A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ILE A 156
ASP A 110
SER A 209
ASN A 259
LEU A 310
 None
 1.15A 4gh8A-4ir8A:
undetectable		 4gh8A-4ir8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 GLY A 160
PRO A 161
ILE A  37
GLY A 122
LEU A 109
 None
 1.12A 4n48A-4ir8A:
undetectable		 4n48A-4ir8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 LEU A  31
LEU A 183
ALA A 153
SER A 154
LEU A 155
 None
 1.08A 4o1zB-4ir8A:
undetectable		 4o1zB-4ir8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ASP A  32
GLY A 191
GLY A  35
ASN A 190
ALA A  40
 None
 1.17A 4ubeA-4ir8A:
undetectable		 4ubeA-4ir8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 6 VAL A 177
LEU A 155
SER A 154
ILE A  30
 None
 1.06A 5jw1A-4ir8A:
undetectable		 5jw1A-4ir8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 8 TRP A 119
PRO A 244
GLY A 240
ASP A 245
 None
 1.16A 5kf8A-4ir8A:
undetectable		 5kf8A-4ir8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 8 TRP A 119
PRO A 244
GLY A 240
ASP A 245
 None
 1.10A 5kgpA-4ir8A:
undetectable		 5kgpA-4ir8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 8 TRP A 119
PRO A 244
GLY A 240
ASP A 245
 None
 1.13A 5kgpB-4ir8A:
undetectable		 5kgpB-4ir8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		4 / 7 ILE A  27
LEU A  23
ARG A  33
LEU A 104
 None
 0.94A 5zcqA-4ir8A:
undetectable
5zcqJ-4ir8A:
undetectable		 5zcqA-4ir8A:
19.66
5zcqJ-4ir8A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE
(Toxoplasma
gondii) 		5 / 11 ILE A 127
ASP A  20
ALA A  19
PHE A 102
ALA A  81
 None
 1.20A 6ieyA-4ir8A:
undetectable
6ieyB-4ir8A:
undetectable		 6ieyA-4ir8A:
23.40
6ieyB-4ir8A:
23.40