SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4irf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		4 / 7 ILE A  40
ILE A  19
VAL A 114
LEU A 117
 None
 0.65A 3r9vA-4irfA:
undetectable
3r9vB-4irfA:
undetectable		 3r9vA-4irfA:
23.79
3r9vB-4irfA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 12 LEU A 145
PHE A  54
LEU A  53
GLY A 120
LEU A 121
 None
 1.29A 3tbgA-4irfA:
undetectable		 3tbgA-4irfA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 12 LEU A 145
PHE A  54
LEU A  53
GLY A 120
LEU A 121
 None
 1.30A 3tbgC-4irfA:
undetectable		 3tbgC-4irfA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		4 / 7 SER A  47
ASP A  48
THR A  16
ILE A  19
 None
 0.88A 4acaC-4irfA:
undetectable		 4acaC-4irfA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 6 SER A  47
ASP A  48
THR A  16
ILE A  19
THR A  52
 None
 1.30A 4acbC-4irfA:
undetectable		 4acbC-4irfA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 12 PHE A 131
LEU A  72
ILE A  68
ILE A  26
GLY A 120
 None
 1.07A 4enhA-4irfA:
undetectable		 4enhA-4irfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 12 GLY A 120
ALA A 100
VAL A 112
ASN A  89
ILE A  40
 None
 1.13A 4pd9A-4irfA:
undetectable		 4pd9A-4irfA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A  68
PHE A 131
THR A  96
LEU A 117
HIS A 116
 None
 1.21A 5v5zA-4irfA:
undetectable		 5v5zA-4irfA:
14.66