SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4irn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 LEU A  76
ASP A  82
GLY A  84
PHE A  87
ALA A  41
 None
None
None
FAD  A 400 (-4.9A)
None
 1.12A 1axwA-4irnA:
undetectable		 1axwA-4irnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 LEU A  76
ASP A  82
GLY A  84
PHE A  87
ALA A  41
 None
None
None
FAD  A 400 (-4.9A)
None
 1.03A 1hvyD-4irnA:
undetectable		 1hvyD-4irnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 8 ILE A 248
PHE A  87
VAL A 211
SER A 124
 None
FAD  A 400 (-4.9A)
None
None
 1.17A 1kb9A-4irnA:
undetectable
1kb9C-4irnA:
undetectable
1kb9D-4irnA:
undetectable
1kb9E-4irnA:
undetectable		 1kb9A-4irnA:
22.86
1kb9C-4irnA:
22.54
1kb9D-4irnA:
19.09
1kb9E-4irnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		3 / 3 ASP A 166
ASP A 191
ASN A 161
 None
 0.70A 2bm9D-4irnA:
undetectable		 2bm9D-4irnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 LEU A  76
ASP A  82
GLY A  84
PHE A  87
ALA A  41
 None
None
None
FAD  A 400 (-4.9A)
None
 1.04A 2kceA-4irnA:
undetectable		 2kceA-4irnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 LEU A  76
ASP A  82
GLY A  84
PHE A  87
ALA A  41
 None
None
None
FAD  A 400 (-4.9A)
None
 1.04A 2kceB-4irnA:
undetectable		 2kceB-4irnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 8 ARG A 356
LEU A  28
ASP A  32
GLY A 205
 None
 0.91A 2qqcH-4irnA:
undetectable
2qqcK-4irnA:
undetectable		 2qqcH-4irnA:
18.21
2qqcK-4irnA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 8 TYR A 364
GLN A 371
ILE A 325
SER A 368
 None
 1.17A 2xz5B-4irnA:
undetectable
2xz5E-4irnA:
undetectable		 2xz5B-4irnA:
19.74
2xz5E-4irnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 7 GLN A 371
ILE A 325
SER A 368
TYR A 364
 None
 1.18A 2xz5D-4irnA:
undetectable
2xz5E-4irnA:
undetectable		 2xz5D-4irnA:
19.74
2xz5E-4irnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 11 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.16A 2y7kA-4irnA:
undetectable		 2y7kA-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.18A 2y7kC-4irnA:
undetectable		 2y7kC-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.15A 2y7kD-4irnA:
undetectable		 2y7kD-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 10 ILE A 370
GLY A 366
GLY A 133
PHE A 237
ILE A 136
 None
FAD  A 400 ( 4.8A)
FAD  A 400 (-3.5A)
None
None
 1.18A 2y7pA-4irnA:
undetectable		 2y7pA-4irnA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		3 / 3 ASP A  32
LEU A  28
GLN A 262
 None
 0.81A 3g4lA-4irnA:
undetectable		 3g4lA-4irnA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 LEU A 100
ILE A 169
LEU A 167
ASP A 166
SER A  46
 None
 1.19A 3ko0K-4irnA:
undetectable
3ko0L-4irnA:
0.6
3ko0S-4irnA:
undetectable
3ko0T-4irnA:
undetectable		 3ko0K-4irnA:
12.62
3ko0L-4irnA:
12.62
3ko0S-4irnA:
12.62
3ko0T-4irnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 TRP A  94
GLY A 162
ALA A 165
ILE A  55
MET A  98
 None
 1.05A 3ld6A-4irnA:
undetectable		 3ld6A-4irnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 5 ILE A 236
THR A 185
THR A 184
PHE A 171
 None
 1.21A 3snfA-4irnA:
undetectable		 3snfA-4irnA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 7 PRO A  54
LEU A  76
ASN A  90
ILE A  93
 None
 0.96A 3u5jA-4irnA:
2.3		 3u5jA-4irnA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 11 LEU A  76
ASP A  82
GLY A  84
PHE A  87
ALA A  41
 None
None
None
FAD  A 400 (-4.9A)
None
 1.14A 4fogD-4irnA:
undetectable		 4fogD-4irnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		4 / 6 ARG A 215
GLY A 154
GLU A 217
GLN A 131
 None
 1.01A 4g0vB-4irnA:
2.1		 4g0vB-4irnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 ARG A 258
LEU A 259
VAL A 330
ILE A 359
GLY A 205
 None
 1.03A 4jecB-4irnA:
undetectable		 4jecB-4irnA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		3 / 3 TYR A 302
GLN A   9
TRP A 306
 None
 1.15A 4kn2C-4irnA:
undetectable		 4kn2C-4irnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		3 / 3 THR A 160
ALA A  91
ASN A 161
 FAD  A 400 (-3.9A)
None
None
 0.48A 5ersA-4irnA:
undetectable		 5ersA-4irnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4irn PROLYL-ACP
DEHYDROGENASE
([Oscillatoria]
sp.
PCC
6506) 		5 / 12 ARG A 258
LEU A 259
VAL A 330
ILE A 359
GLY A 205
 None
 1.01A 5kqyA-4irnA:
undetectable		 5kqyA-4irnA:
14.46