SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4irq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 11 SER A 218
GLY A 286
ASN A 140
GLY A 285
ASP A 282
 None
 1.31A 1ho5A-4irqA:
undetectable		 1ho5A-4irqA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.13A 1hrkA-4irqA:
undetectable		 1hrkA-4irqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 SER A 152
PRO A 100
LEU A 119
MET A 115
TYR A 175
 None
UDP  A 402 (-4.2A)
None
None
None
 1.46A 1p33D-4irqA:
undetectable		 1p33D-4irqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		4 / 7 HIS A  83
THR A 308
TYR A 129
LEU A  98
 None
 1.08A 1qzrA-4irqA:
undetectable		 1qzrA-4irqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		4 / 7 HIS A  83
THR A 308
TYR A 129
LEU A  98
 None
 1.07A 1qzrB-4irqA:
undetectable		 1qzrB-4irqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.04A 2po5A-4irqA:
2.8		 2po5A-4irqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 11 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.05A 2po5B-4irqA:
2.9		 2po5B-4irqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.00A 2qd4A-4irqA:
2.8		 2qd4A-4irqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.06A 2qd4B-4irqA:
1.9		 2qd4B-4irqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 TYR A 194
GLY A 223
GLU A 227
GLY A 225
HIS A 259
 UDP  A 402 (-4.6A)
None
TRS  A 403 (-2.5A)
TRS  A 403 (-3.2A)
MN  A 401 ( 3.4A)
 1.04A 3f8wB-4irqA:
undetectable		 3f8wB-4irqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		4 / 8 ASP A 165
ASP A 163
ASP A 260
TYR A 194
 MN  A 401 ( 2.7A)
UDP  A 402 (-3.3A)
None
UDP  A 402 (-4.6A)
 1.12A 3havA-4irqA:
undetectable		 3havA-4irqA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 HIS A 184
ILE A 203
LEU A 258
HIS A 191
TYR A 199
 None
None
None
None
TRS  A 403 (-4.9A)
 1.33A 3vn2A-4irqA:
undetectable		 3vn2A-4irqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 12 HIS A 195
HIS A 257
ASP A 163
GLY A 202
TYR A 199
 None
MN  A 401 ( 3.5A)
UDP  A 402 (-3.3A)
None
TRS  A 403 (-4.9A)
 1.12A 4lxzA-4irqA:
undetectable		 4lxzA-4irqA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens) 		5 / 11 HIS A 195
HIS A 257
ASP A 163
GLY A 202
TYR A 199
 None
MN  A 401 ( 3.5A)
UDP  A 402 (-3.3A)
None
TRS  A 403 (-4.9A)
 1.12A 4lxzB-4irqA:
undetectable		 4lxzB-4irqA:
22.89