SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4is2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 PHE A  62
ILE A  10
GLY A  13
PHE A  36
ALA A  21
 None
 1.15A 1hvyA-4is2A:
undetectable		 1hvyA-4is2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		4 / 7 LYS A 132
ALA A 127
TRP A 125
MET A  73
 None
 1.26A 3tx2A-4is2A:
3.7		 3tx2A-4is2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		4 / 7 VAL A  72
VAL A  76
ASN A 141
VAL A   8
 None
 0.99A 4e1gB-4is2A:
undetectable		 4e1gB-4is2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		4 / 7 ALA A  93
GLY A  17
GLY A  14
ILE A  11
 None
 0.67A 4eatA-4is2A:
3.7		 4eatA-4is2A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A  19
GLY A  14
GLY A  13
ALA A 222
VAL A 190
 None
 0.89A 4htfA-4is2A:
7.1		 4htfA-4is2A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		6 / 10 GLU A 174
ILE A 180
VAL A 182
ALA A 124
ALA A 127
ILE A 139
 None
 1.36A 4lbgA-4is2A:
6.7		 4lbgA-4is2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 VAL A 120
LEU A 228
TYR A 225
VAL A 182
GLY A 184
 None
 1.03A 4rrxB-4is2A:
undetectable		 4rrxB-4is2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A  17
ARG A  16
ALA A  22
ALA A  23
ILE A  11
 None
 0.91A 5kb6B-4is2A:
5.9		 5kb6B-4is2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 10 PHE A  62
ILE A  10
GLY A  13
PHE A  36
ALA A  21
 None
 1.26A 5x66D-4is2A:
undetectable		 5x66D-4is2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 10 ARG A 177
TYR A 128
ALA A 127
LEU A 171
VAL A 182
 None
 1.36A 5zbdB-4is2A:
3.8		 5zbdB-4is2A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		5 / 10 ASP A  65
THR A  67
THR A  12
GLY A  13
GLU A  38
 None
 1.16A 6mb9A-4is2A:
undetectable		 6mb9A-4is2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4is2 BILE ACID 3-ALPHA
HYDROXYSTEROID
DEHYDROGENASE
([Clostridium]
scindens) 		4 / 4 ASP A 244
ILE A 221
PRO A 218
LEU A 216
 None
 1.29A 6mkeA-4is2A:
undetectable		 6mkeA-4is2A:
15.53