SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4is4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		3 / 3 MET A   1
LEU A   4
SER A   5
 None
 0.66A 1ee2A-4is4A:
undetectable		 1ee2A-4is4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PRO A 124
VAL A 206
THR A 344
VAL A 119
 None
 0.99A 1jgsA-4is4A:
undetectable		 1jgsA-4is4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		3 / 3 LEU A 180
HIS A 175
ILE A 220
 None
 0.71A 1s9pB-4is4A:
undetectable		 1s9pB-4is4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		3 / 3 ARG A 311
SER A 233
TYR A 132
 None
 0.76A 1x70A-4is4A:
undetectable		 1x70A-4is4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.04A 1yrcA-4is4A:
undetectable		 1yrcA-4is4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 10 ARG A 218
THR A 250
GLY A 203
ALA A 210
VAL A 343
 None
 1.22A 2coiA-4is4A:
undetectable
2coiB-4is4A:
undetectable		 2coiA-4is4A:
22.57
2coiB-4is4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 11 ARG A 218
THR A 250
GLY A 203
ALA A 210
VAL A 343
 None
 1.19A 2cojA-4is4A:
undetectable
2cojB-4is4A:
undetectable		 2cojA-4is4A:
22.57
2cojB-4is4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 9 VAL A 343
ARG A 218
THR A 250
GLY A 203
ALA A 210
 None
 1.26A 2cojA-4is4A:
undetectable
2cojB-4is4A:
undetectable		 2cojA-4is4A:
22.57
2cojB-4is4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 6 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.03A 2zuiA-4is4A:
undetectable		 2zuiA-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.04A 2zwtA-4is4A:
undetectable		 2zwtA-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.03A 2zwuA-4is4A:
undetectable		 2zwuA-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 12 GLY A 168
GLY A 160
GLY A 191
GLY A 196
ILE A 161
 None
 0.93A 3elwA-4is4A:
undetectable		 3elwA-4is4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 9 ALA A 174
ASP A 170
ILE A 171
ILE A 186
ILE A 224
 None
 0.99A 3nu4A-4is4A:
undetectable		 3nu4A-4is4A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.05A 3wrjA-4is4A:
undetectable		 3wrjA-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.04A 3wrlE-4is4A:
undetectable		 3wrlE-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 7 PHE A 329
TYR A 252
THR A 254
LEU A 352
 None
 1.05A 3wrmF-4is4A:
undetectable		 3wrmF-4is4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 6 ASN A  61
GLY A  65
PRO A 103
THR A 104
 None
 1.07A 4l1aB-4is4A:
undetectable		 4l1aB-4is4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		4 / 5 MET A 194
TYR A 150
GLY A 149
GLY A 148
 None
 1.03A 5x7pA-4is4A:
undetectable		 5x7pA-4is4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4is4 GLUTAMINE SYNTHETASE
(Medicago
truncatula) 		5 / 12 GLU A 122
VAL A 119
PRO A 124
PHE A 329
THR A 321
 None
 1.35A 5xiqC-4is4A:
undetectable		 5xiqC-4is4A:
20.75