SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4is7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 6 ASP A 125
LEU A 122
GLY A 121
ARG A 156
 None
 0.85A 1mt1G-4is7A:
undetectable
1mt1J-4is7A:
undetectable		 1mt1G-4is7A:
17.65
1mt1J-4is7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 7 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.83A 1mt1H-4is7A:
undetectable
1mt1K-4is7A:
undetectable		 1mt1H-4is7A:
21.43
1mt1K-4is7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 7 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.84A 1n13D-4is7A:
undetectable
1n13E-4is7A:
undetectable		 1n13D-4is7A:
21.43
1n13E-4is7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 6 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.85A 1n13H-4is7A:
undetectable
1n13K-4is7A:
undetectable		 1n13H-4is7A:
21.43
1n13K-4is7A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 7 ASP A 125
LEU A 122
GLY A 121
ARG A 156
 None
 0.86A 1n13G-4is7A:
undetectable
1n13J-4is7A:
undetectable		 1n13G-4is7A:
17.65
1n13J-4is7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4is7 CASKIN-2
(Homo
sapiens) 		3 / 3 LEU A 103
LEU A  97
MET A 120
 None
 0.77A 1ya3B-4is7A:
undetectable		 1ya3B-4is7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 7 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.85A 2qqcD-4is7A:
undetectable
2qqcE-4is7A:
undetectable		 2qqcD-4is7A:
22.47
2qqcE-4is7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 8 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.85A 2qqcH-4is7A:
undetectable
2qqcK-4is7A:
undetectable		 2qqcH-4is7A:
22.47
2qqcK-4is7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4is7 CASKIN-2
(Homo
sapiens) 		4 / 8 ARG A 156
ASP A 125
LEU A 122
GLY A 121
 None
 0.87A 2qqdB-4is7A:
undetectable
2qqdC-4is7A:
undetectable		 2qqdB-4is7A:
21.43
2qqdC-4is7A:
22.16