SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4isa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 120
ILE A  89
ILE A  92
VAL A  11
LEU A  28
 None
 1.06A 1qhyA-4isaA:
undetectable		 1qhyA-4isaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 4 LEU A  26
ILE A  89
ARG A   5
TYR A  39
 None
 1.32A 1rk3A-4isaA:
undetectable		 1rk3A-4isaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 11 GLY A 193
VAL A 217
GLU A 234
ILE A 198
HIS A  79
 GVR  A 402 (-3.6A)
None
None
FMT  A 405 ( 3.7A)
ZN  A 401 ( 3.3A)
 1.08A 1vhwA-4isaA:
undetectable
1vhwD-4isaA:
undetectable		 1vhwA-4isaA:
21.47
1vhwD-4isaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 11 GLY A 193
VAL A 217
GLU A 234
ILE A 198
HIS A  79
 GVR  A 402 (-3.6A)
None
None
FMT  A 405 ( 3.7A)
ZN  A 401 ( 3.3A)
 1.07A 1vhwC-4isaA:
undetectable
1vhwE-4isaA:
undetectable		 1vhwC-4isaA:
21.47
1vhwE-4isaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 11 HIS A  79
GLY A 193
VAL A 217
GLU A 234
ILE A 198
 ZN  A 401 ( 3.3A)
GVR  A 402 (-3.6A)
None
None
FMT  A 405 ( 3.7A)
 1.06A 1vhwA-4isaA:
undetectable
1vhwD-4isaA:
undetectable		 1vhwA-4isaA:
21.47
1vhwD-4isaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 11 HIS A  79
GLY A 193
VAL A 217
GLU A 234
ILE A 198
 ZN  A 401 ( 3.3A)
GVR  A 402 (-3.6A)
None
None
FMT  A 405 ( 3.7A)
 1.08A 1vhwC-4isaA:
undetectable
1vhwE-4isaA:
undetectable		 1vhwC-4isaA:
21.47
1vhwE-4isaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ALA A  52
LEU A  80
ILE A 101
ILE A  74
LEU A  84
 None
 1.03A 1xdkB-4isaA:
undetectable		 1xdkB-4isaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 5 GLU A 234
ARG A 188
ASP A 233
ASP A 167
 None
D1D  A 421 (-4.6A)
None
None
 1.40A 2yqzA-4isaA:
undetectable		 2yqzA-4isaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 5 GLU A 234
ARG A 188
ASP A 233
ASP A 167
 None
D1D  A 421 (-4.6A)
None
None
 1.42A 2yqzB-4isaA:
undetectable		 2yqzB-4isaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 5 ALA A 181
GLN A 185
ILE A 186
ARG A 237
 FMT  A 406 (-3.8A)
FMT  A 406 ( 3.8A)
None
None
 1.38A 2z0aA-4isaA:
undetectable		 2z0aA-4isaA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 5 LEU A  26
ILE A  89
ARG A   5
TYR A  39
 None
 1.28A 2zlcA-4isaA:
undetectable		 2zlcA-4isaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 7 ASN A  81
MET A 249
LEU A 272
LEU A  66
 None
 1.07A 3nk2X-4isaA:
undetectable		 3nk2X-4isaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 9 LEU A 267
THR A 158
ALA A 260
LEU A 271
THR A 259
 None
 1.46A 3ozkA-4isaA:
undetectable		 3ozkA-4isaA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		3 / 3 ARG A 196
PRO A 164
PHE A 194
 None
 1.05A 3thrC-4isaA:
undetectable		 3thrC-4isaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		3 / 3 ARG A 237
TYR A 261
ASN A 268
 None
FMT  A 415 (-3.4A)
None
 0.91A 4ffwB-4isaA:
undetectable		 4ffwB-4isaA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		6 / 12 ALA A  82
LEU A 115
PHE A 111
ILE A  94
LEU A  26
ILE A 101
 None
 1.36A 4nx7A-4isaA:
undetectable		 4nx7A-4isaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		6 / 12 ALA A  82
LEU A 115
PHE A 111
ILE A  94
LEU A  26
ILE A 101
 None
 1.38A 4pssA-4isaA:
undetectable		 4pssA-4isaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		4 / 8 ILE A 244
ASN A 253
ILE A 120
PHE A 182
 None
FMT  A 420 (-3.7A)
None
None
 0.78A 4r38A-4isaA:
undetectable		 4r38A-4isaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 9 ILE A 244
ASN A 253
LEU A  87
ILE A 120
PHE A 182
 None
FMT  A 420 (-3.7A)
None
None
None
 1.26A 4r38C-4isaA:
undetectable		 4r38C-4isaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 11 VAL A 223
VAL A 218
ILE A 159
ILE A 166
LEU A 229
 None
 1.01A 5e4dB-4isaA:
undetectable		 5e4dB-4isaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 216
ILE A 103
ILE A 186
ARG A 237
ALA A  82
 None
 0.95A 5e72A-4isaA:
undetectable		 5e72A-4isaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Escherichia
coli) 		3 / 3 VAL A  96
ARG A 190
PRO A 110
 None
None
FMT  A 410 (-4.2A)
 0.75A 5koxA-4isaA:
undetectable		 5koxA-4isaA:
22.50