SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4isc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4isc METHYLTRANSFERASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ARG A  44
GLY A 138
ASP A 137
 None
 0.47A 1kf6A-4iscA:
3.7
1kf6B-4iscA:
undetectable		 1kf6A-4iscA:
14.74
1kf6B-4iscA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4isc METHYLTRANSFERASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 GLY A  50
ASP A  71
ASN A  53
 BME  A 301 ( 4.7A)
None
None
 0.66A 1vq1A-4iscA:
10.7		 1vq1A-4iscA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 4isc METHYLTRANSFERASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 GLU A  27
GLU A 113
ASN A  53
 None
 0.90A 3lp9B-4iscA:
undetectable
3lp9D-4iscA:
undetectable		 3lp9B-4iscA:
16.81
3lp9D-4iscA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4isc METHYLTRANSFERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU A 123
LEU A 126
LEU A 167
HIS A 160
 None
 0.75A 5gs4A-4iscA:
undetectable		 5gs4A-4iscA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4isc METHYLTRANSFERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 HIS A 144
ASN A  53
VAL A 110
LEU A 140
 None
 1.45A 5xdhA-4iscA:
undetectable
5xdhC-4iscA:
undetectable		 5xdhA-4iscA:
17.65
5xdhC-4iscA:
17.65