SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4isd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4isd GLUTATHIONE
S-TRANSFERASE
(Burkholderia
glumae) 		4 / 8 LEU A 146
LEU A 175
TYR A 192
LEU A 105
 None
 0.92A 1hk2A-4isdA:
2.1		 1hk2A-4isdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4isd GLUTATHIONE
S-TRANSFERASE
(Burkholderia
glumae) 		4 / 6 GLU A  28
ARG A 110
ASP A 170
LEU A 173
 None
GSH  A 301 (-4.7A)
None
None
 1.00A 1mt1B-4isdA:
undetectable
1mt1C-4isdA:
undetectable		 1mt1B-4isdA:
18.02
1mt1C-4isdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4isd GLUTATHIONE
S-TRANSFERASE
(Burkholderia
glumae) 		4 / 6 PHE A  18
PRO A  60
GLU A  71
SER A  72
 GSH  A 301 (-4.2A)
GSH  A 301 (-4.4A)
GSH  A 301 (-3.1A)
GSH  A 301 (-2.7A)
 0.34A 3vlnA-4isdA:
4.0		 3vlnA-4isdA:
24.80