SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 9 LEU A 443
LEU A 255
ILE A 370
THR A 429
ILE A 431
 None
 1.45A 1hzeA-4issA:
undetectable
1hzeB-4issA:
undetectable		 1hzeA-4issA:
9.45
1hzeB-4issA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 9 THR A 429
ILE A 431
LEU A 443
LEU A 255
ILE A 370
 None
 1.45A 1hzeA-4issA:
undetectable
1hzeB-4issA:
undetectable		 1hzeA-4issA:
9.45
1hzeB-4issA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 10 ASP A 474
LEU A 473
ILE A 188
THR A 468
ILE A 467
 None
 1.31A 1i18A-4issA:
undetectable
1i18B-4issA:
undetectable		 1i18A-4issA:
9.45
1i18B-4issA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 10 THR A 468
ILE A 467
ASP A 474
LEU A 473
ILE A 188
 None
 1.31A 1i18A-4issA:
undetectable
1i18B-4issA:
undetectable		 1i18A-4issA:
9.45
1i18B-4issA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
SER A 154
ILE A  82
 TAR  A 701 (-2.7A)
None
None
None
None
 1.09A 1pk9C-4issA:
undetectable		 1pk9C-4issA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
ILE A  82
ARG A 313
 TAR  A 701 (-2.7A)
None
None
None
TAR  A 701 (-2.9A)
 1.08A 1vhwA-4issA:
undetectable
1vhwD-4issA:
undetectable		 1vhwA-4issA:
16.69
1vhwD-4issA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
ILE A  82
ARG A 313
 TAR  A 701 (-2.7A)
None
None
None
TAR  A 701 (-2.9A)
 1.07A 1vhwC-4issA:
undetectable
1vhwE-4issA:
undetectable		 1vhwC-4issA:
16.69
1vhwE-4issA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 ARG A 313
SER A 177
GLY A 171
VAL A 212
ILE A  82
 TAR  A 701 (-2.9A)
TAR  A 701 (-2.7A)
None
None
None
 1.09A 1vhwA-4issA:
undetectable
1vhwD-4issA:
undetectable		 1vhwA-4issA:
16.69
1vhwD-4issA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 ARG A 313
SER A 177
GLY A 171
VAL A 212
ILE A  82
 TAR  A 701 (-2.9A)
TAR  A 701 (-2.7A)
None
None
None
 1.09A 1vhwC-4issA:
undetectable
1vhwE-4issA:
undetectable		 1vhwC-4issA:
16.69
1vhwE-4issA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ALA A 155
ASP A 124
GLY A 152
GLY A 151
 None
 0.68A 2c49B-4issA:
undetectable		 2c49B-4issA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		3 / 3 ALA A 155
THR A 140
PHE A 215
 None
 0.72A 2c6nB-4issA:
undetectable		 2c6nB-4issA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.27A 2f9wA-4issA:
undetectable
2f9wB-4issA:
undetectable		 2f9wA-4issA:
19.84
2f9wB-4issA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 SER A 213
SER A 169
VAL A 214
SER A 154
 None
 1.48A 2j9cA-4issA:
undetectable
2j9cB-4issA:
2.2
2j9cC-4issA:
0.3		 2j9cA-4issA:
12.58
2j9cB-4issA:
12.58
2j9cC-4issA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 6 GLY A 579
PRO A 513
LYS A 514
THR A 515
 None
 1.21A 2m2oB-4issA:
undetectable		 2m2oB-4issA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 10 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.33A 3bexC-4issA:
undetectable
3bexD-4issA:
undetectable		 3bexC-4issA:
17.51
3bexD-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 10 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.27A 3bexC-4issA:
undetectable
3bexD-4issA:
undetectable		 3bexC-4issA:
17.51
3bexD-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 10 VAL A 538
THR A 601
ILE A 546
LEU A 535
THR A 515
 None
 1.32A 3bexE-4issA:
undetectable
3bexF-4issA:
undetectable		 3bexE-4issA:
17.51
3bexF-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.32A 3bexE-4issA:
undetectable
3bexF-4issA:
undetectable		 3bexE-4issA:
17.51
3bexF-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.28A 3bf1A-4issA:
undetectable
3bf1B-4issA:
undetectable		 3bf1A-4issA:
17.51
3bf1B-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.33A 3bf1C-4issA:
undetectable
3bf1D-4issA:
undetectable		 3bf1C-4issA:
17.51
3bf1D-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.29A 3bf1C-4issA:
undetectable
3bf1D-4issA:
undetectable		 3bf1C-4issA:
17.51
3bf1D-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 11 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.29A 3bf1E-4issA:
undetectable
3bf1F-4issA:
undetectable		 3bf1E-4issA:
17.51
3bf1F-4issA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 TYR A 148
ASN A 381
PRO A 272
TRP A 265
 None
 1.42A 3bjwD-4issA:
undetectable		 3bjwD-4issA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 7 VAL A 538
LYS A 520
ILE A 546
GLY A 605
LEU A 493
 None
 1.47A 3bjwH-4issA:
undetectable		 3bjwH-4issA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		6 / 12 LEU A  25
GLY A 114
LEU A  69
GLN A  56
LEU A  53
ILE A  48
 None
 1.45A 3ijdA-4issA:
undetectable		 3ijdA-4issA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 5 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.37A 3ijxH-4issA:
2.4		 3ijxH-4issA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.09A 3iv6A-4issA:
undetectable		 3iv6A-4issA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-4issA:
undetectable		 3iv6C-4issA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 GLY A 156
CYH A 378
PHE A 419
PHE A 144
 None
 1.02A 3ko0D-4issA:
undetectable
3ko0E-4issA:
undetectable		 3ko0D-4issA:
9.94
3ko0E-4issA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 PHE A 144
GLY A 156
CYH A 378
PHE A 419
 None
 0.96A 3ko0B-4issA:
undetectable
3ko0J-4issA:
undetectable		 3ko0B-4issA:
9.94
3ko0J-4issA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 GLY A 178
CYH A 374
PHE A 294
PHE A 404
 None
 1.12A 3ko0L-4issA:
undetectable
3ko0N-4issA:
undetectable		 3ko0L-4issA:
9.94
3ko0N-4issA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 PHE A 404
GLY A 178
CYH A 374
PHE A 294
 None
 1.09A 3ko0R-4issA:
undetectable
3ko0T-4issA:
undetectable		 3ko0R-4issA:
9.94
3ko0T-4issA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 0.99A 3olsA-4issA:
undetectable		 3olsA-4issA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 0.98A 3q95B-4issA:
undetectable		 3q95B-4issA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 6 PHE A 561
PHE A 558
PHE A 585
ALA A 487
 None
 1.09A 3t3sB-4issA:
undetectable		 3t3sB-4issA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 LEU A 535
ARG A 536
GLY A 604
SER A 544
 None
 0.99A 4cp3A-4issA:
undetectable
4cp3B-4issA:
undetectable		 4cp3A-4issA:
10.40
4cp3B-4issA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		3 / 3 ASN A 230
ASP A 437
ASP A 409
 None
 0.76A 4obwD-4issA:
undetectable		 4obwD-4issA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 0.96A 4pxmA-4issA:
undetectable		 4pxmA-4issA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.45A 4v2yC-4issA:
undetectable		 4v2yC-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.49A 4v2zC-4issA:
undetectable		 4v2zC-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 5 LEU A 443
ASP A 442
LEU A 430
THR A 285
 None
 1.27A 4wozF-4issA:
undetectable
4wozH-4issA:
undetectable		 4wozF-4issA:
19.53
4wozH-4issA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 ASP A  11
TYR A 459
ILE A 188
ASP A 471
 None
 1.01A 4xjeA-4issA:
undetectable		 4xjeA-4issA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 123
SER A 154
GLY A 132
GLY A 151
GLY A 129
 None
None
None
None
TAR  A 701 (-3.7A)
 1.11A 4yvgA-4issA:
undetectable		 4yvgA-4issA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ASP A 210
GLY A 171
THR A 174
LYS A  79
 None
None
TAR  A 701 (-3.6A)
None
 1.12A 4zxiA-4issA:
3.2		 4zxiA-4issA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.37A 5amhA-4issA:
undetectable		 5amhA-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 PRO A 244
PHE A 435
SER A 436
TYR A 251
 None
 1.27A 5amiB-4issA:
undetectable		 5amiB-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 VAL A 538
THR A 601
ILE A 546
LEU A 535
THR A 515
 None
 1.28A 5b8hA-4issA:
undetectable
5b8hB-4issA:
undetectable		 5b8hA-4issA:
20.98
5b8hB-4issA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.26A 5b8hA-4issA:
undetectable
5b8hB-4issA:
undetectable		 5b8hA-4issA:
20.98
5b8hB-4issA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 ALA A 155
THR A 172
GLY A 129
GLY A 152
GLY A 178
 None
None
TAR  A 701 (-3.7A)
None
None
 0.81A 5c0oG-4issA:
undetectable		 5c0oG-4issA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 ASP A  11
TYR A 459
ILE A 188
ASP A 471
 None
 0.95A 5cfsA-4issA:
undetectable		 5cfsA-4issA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		3 / 3 PRO A 136
ILE A  82
SER A 328
 None
 0.79A 5fsaA-4issA:
undetectable		 5fsaA-4issA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 5 GLY A 176
PRO A 379
THR A 402
GLN A 398
 TAR  A 701 (-3.7A)
None
None
None
 0.98A 5h5fA-4issA:
undetectable		 5h5fA-4issA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 6 VAL A 372
LEU A 255
CYH A 374
LEU A 282
 None
 0.94A 5hrqB-4issA:
undetectable
5hrqI-4issA:
undetectable
5hrqJ-4issA:
undetectable		 5hrqB-4issA:
8.26
5hrqI-4issA:
3.76
5hrqJ-4issA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 9 SER A 213
GLY A 178
ALA A 158
LEU A 187
GLY A 189
 None
 1.44A 5l8rA-4issA:
undetectable		 5l8rA-4issA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 8 GLY A 460
ALA A 182
PHE A 144
PHE A 419
 None
 0.88A 5mvsB-4issA:
undetectable		 5mvsB-4issA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 4 ASN A 185
SER A 154
ALA A 158
VAL A 161
 None
 1.40A 5nm5A-4issA:
undetectable		 5nm5A-4issA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		3 / 3 GLY A 138
THR A 140
ASN A 122
 None
 0.57A 5odiG-4issA:
undetectable		 5odiG-4issA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.47A 5oh3A-4issA:
undetectable		 5oh3A-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 ALA A 278
PHE A 448
PHE A 447
LEU A 441
LEU A 219
 None
 0.82A 5tudA-4issA:
undetectable		 5tudA-4issA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.28A 5vlmC-4issA:
undetectable		 5vlmC-4issA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 6 GLY A 129
SER A 135
THR A 133
VAL A 131
 TAR  A 701 (-3.7A)
None
None
None
 1.24A 5ysiA-4issA:
undetectable		 5ysiA-4issA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 7 ARG A 200
ARG A 102
THR A 101
PRO A 100
 None
 1.27A 6a4iB-4issA:
undetectable		 6a4iB-4issA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		4 / 4 ARG A 420
SER A 421
ASP A 422
ASN A 271
 None
 0.94A 6ag0A-4issA:
undetectable		 6ag0A-4issA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4iss ALLOPHANATE
HYDROLASE
(Kluyveromyces
lactis) 		5 / 12 ALA A 183
ASN A 381
GLY A 427
SER A 417
GLY A 418
 None
 1.12A 6c79A-4issA:
undetectable		 6c79A-4issA:
10.25