SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4isy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 200
GLY A  78
ALA A 198
ILE A  79
 None
 0.75A 1c9sI-4isyA:
undetectable
1c9sJ-4isyA:
undetectable		 1c9sI-4isyA:
11.50
1c9sJ-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  78
ALA A 198
ILE A  79
SER A 200
 None
 0.76A 1c9sU-4isyA:
undetectable
1c9sV-4isyA:
undetectable		 1c9sU-4isyA:
11.50
1c9sV-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  45
ILE A  44
ARG A 237
 None
 0.83A 1cd2A-4isyA:
0.9		 1cd2A-4isyA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A  78
ALA A 198
ILE A  79
SER A 200
 None
 0.69A 1gtnA-4isyA:
undetectable
1gtnK-4isyA:
undetectable		 1gtnA-4isyA:
11.50
1gtnK-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 200
GLY A  78
ALA A 198
ILE A  79
 None
 0.73A 1gtnE-4isyA:
undetectable
1gtnF-4isyA:
undetectable		 1gtnE-4isyA:
11.50
1gtnF-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 177
LEU A  74
SER A  71
ASP A  72
 None
None
None
LLP  A 205 ( 4.6A)
 1.12A 1ismB-4isyA:
undetectable		 1ismB-4isyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 257
ALA A 256
HIS A 360
 None
 0.51A 1q23C-4isyA:
undetectable		 1q23C-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 257
ALA A 256
HIS A 360
 None
 0.53A 1q23H-4isyA:
undetectable		 1q23H-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 257
ALA A 256
HIS A 360
 None
 0.50A 1q23G-4isyA:
undetectable		 1q23G-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 257
ALA A 256
HIS A 360
 None
 0.58A 1q23L-4isyA:
undetectable		 1q23L-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 257
ALA A 256
HIS A 360
 None
 0.56A 1q23J-4isyA:
undetectable		 1q23J-4isyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 310
LEU A 313
HIS A 101
 None
 0.72A 1qknA-4isyA:
undetectable		 1qknA-4isyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  78
ALA A 198
ILE A  79
SER A 200
 None
 0.79A 1utdI-4isyA:
undetectable
1utdJ-4isyA:
undetectable		 1utdI-4isyA:
11.50
1utdJ-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 157
ASN A 153
LEU A   4
ARG A 355
ASP A 366
 None
 1.16A 2b9eA-4isyA:
3.4		 2b9eA-4isyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 375
GLY A 376
LEU A 354
PHE A 304
 None
 1.03A 2vl2B-4isyA:
undetectable		 2vl2B-4isyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 316
GLY A 320
LEU A 374
VAL A 378
ALA A   2
 None
 1.28A 2vmyB-4isyA:
29.2		 2vmyB-4isyA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 345
SER A 337
SER A 327
VAL A 156
GLY A 289
 None
 1.48A 2x2iD-4isyA:
1.4		 2x2iD-4isyA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 352
GLY A 309
VAL A 378
ALA A 350
THR A 303
 None
 1.13A 3dh0B-4isyA:
undetectable		 3dh0B-4isyA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 371
GLU A 364
LEU A 358
LEU A 270
LEU A   4
 None
 1.00A 3erdA-4isyA:
undetectable		 3erdA-4isyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 356
PHE A 302
LEU A 371
GLU A 281
ALA A 377
ALA A 370
 None
 1.48A 3mdvB-4isyA:
undetectable		 3mdvB-4isyA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 180
ALA A 183
VAL A 201
ALA A 198
SER A 148
 None
 0.96A 3mg0K-4isyA:
undetectable
3mg0L-4isyA:
undetectable		 3mg0K-4isyA:
19.71
3mg0L-4isyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 100
SER A 148
ASN A  73
 LLP  A 205 ( 3.6A)
None
None
 0.84A 3s8pB-4isyA:
undetectable		 3s8pB-4isyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 186
ASN A 299
GLN A 182
THR A   9
 None
None
LLP  A 205 ( 3.9A)
None
 0.95A 4d1yA-4isyA:
2.4
4d1yB-4isyA:
2.4		 4d1yA-4isyA:
21.14
4d1yB-4isyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 302
PHE A 304
LEU A 371
LEU A 374
 None
 0.86A 4ejgB-4isyA:
undetectable		 4ejgB-4isyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 302
PHE A 304
LEU A 371
LEU A 374
 None
 0.88A 4ejgC-4isyA:
undetectable		 4ejgC-4isyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 123
GLY A 127
VAL A 156
HIS A 338
 None
 0.93A 4qwpB-4isyA:
undetectable		 4qwpB-4isyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 274
ASP A 366
ALA A 370
VAL A 373
 None
 0.86A 4zbqA-4isyA:
undetectable		 4zbqA-4isyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 100
SER A 148
ASN A  73
 LLP  A 205 ( 3.6A)
None
None
 0.81A 5cprB-4isyA:
undetectable		 5cprB-4isyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A   8
HIS A 100
ASN A 154
ARG A 355
 None
LLP  A 205 ( 3.6A)
LLP  A 205 ( 4.3A)
None
 0.51A 5db5A-4isyA:
41.9
5db5B-4isyA:
41.7		 5db5A-4isyA:
27.54
5db5B-4isyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 278
LEU A 279
LEU A 371
ALA A 300
LEU A 356
 None
 0.94A 5ikrB-4isyA:
undetectable		 5ikrB-4isyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
VAL A  62
PHE A 206
ALA A 256
GLY A 259
 None
None
LLP  A 205 ( 4.8A)
None
None
 1.09A 5uxdB-4isyA:
undetectable		 5uxdB-4isyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 301
ASN A 288
LEU A 287
 None
 0.84A 6f7lB-4isyA:
undetectable		 6f7lB-4isyA:
24.65