SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4it4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4it4 CG17282
(Drosophila
melanogaster) 		4 / 6 SER A  53
TYR A  55
VAL A  41
ASP A  80
 None
 1.31A 2x45A-4it4A:
undetectable		 2x45A-4it4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4it4 CG17282
(Drosophila
melanogaster) 		4 / 7 VAL A 158
LYS A 162
ILE A 165
LEU A 173
 None
 0.85A 3bjwF-4it4A:
undetectable		 3bjwF-4it4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4it4 CG17282
(Drosophila
melanogaster) 		4 / 7 VAL A 158
LYS A 162
ILE A 165
LEU A 173
 None
 0.59A 3bjwH-4it4A:
undetectable		 3bjwH-4it4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4it4 CG17282
(Drosophila
melanogaster) 		4 / 6 LEU A  83
PHE A 110
LEU A 112
PHE A  90
 None
 1.05A 3wg7C-4it4A:
4.7
3wg7J-4it4A:
undetectable		 3wg7C-4it4A:
20.44
3wg7J-4it4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4it4 CG17282
(Drosophila
melanogaster) 		5 / 12 ALA A 198
PRO A 150
PHE A 146
GLY A 142
SER A 141
 None
 1.20A 5hfjB-4it4A:
undetectable		 5hfjB-4it4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4it4 CG17282
(Drosophila
melanogaster) 		5 / 12 ALA A 198
PRO A 150
PHE A 146
GLY A 142
SER A 141
 None
 1.26A 5hfjF-4it4A:
undetectable		 5hfjF-4it4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4it4 CG17282
(Drosophila
melanogaster) 		4 / 7 LEU A  83
PHE A 110
LEU A 112
PHE A  90
 None
 1.05A 5x1fP-4it4A:
4.7
5x1fW-4it4A:
undetectable		 5x1fP-4it4A:
20.44
5x1fW-4it4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4it4 CG17282
(Drosophila
melanogaster) 		3 / 3 TYR A  55
HIS A  68
PHE A  39
 None
 1.06A 6esmA-4it4A:
undetectable		 6esmA-4it4A:
18.75