SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4itc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 GLY A1056
LEU A1052
LEU A1050
VAL A1130
LEU A1092
 None
 1.07A 1gseB-4itcA:
undetectable		 1gseB-4itcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.35A 3ijxB-4itcA:
undetectable
3ijxD-4itcA:
undetectable		 3ijxB-4itcA:
21.17
3ijxD-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 ILE A 993
PRO A 994
SER A 988
GLY A 992
LEU A1045
 GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
None
 1.38A 3ik6B-4itcA:
undetectable
3ik6E-4itcA:
undetectable		 3ik6B-4itcA:
21.17
3ik6E-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.38A 3ik6B-4itcA:
undetectable
3ik6E-4itcA:
undetectable		 3ik6B-4itcA:
21.17
3ik6E-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 LEU A1045
ILE A 993
PRO A 994
SER A 988
GLY A 992
 None
GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
 1.39A 3iluB-4itcA:
undetectable
3iluE-4itcA:
undetectable		 3iluB-4itcA:
21.17
3iluE-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 11 ILE A 993
PRO A 994
SER A 988
GLY A 992
LEU A1045
 GAI  A1206 (-4.0A)
GOL  A1207 ( 4.9A)
None
None
None
 1.40A 3iluB-4itcA:
undetectable
3iluE-4itcA:
undetectable		 3iluB-4itcA:
21.17
3iluE-4itcA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 6 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.86A 3t3zA-4itcA:
undetectable		 3t3zA-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 6 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.86A 3t3zB-4itcA:
undetectable		 3t3zB-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 5 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.85A 3t3zC-4itcA:
undetectable		 3t3zC-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 6 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.92A 3t3zD-4itcA:
undetectable		 3t3zD-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4itc LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA A1085
ASP A1001
ALA A1002
ASP A1042
TYR A1044
 None
CA  A1201 (-3.1A)
None
None
None
 1.15A 5kvaA-4itcA:
undetectable		 5kvaA-4itcA:
21.43