SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4itm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		4 / 7 VAL A 134
VAL A  41
ILE A  69
LEU A 154
 None
 0.96A 1iepB-4itmA:
undetectable		 1iepB-4itmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		4 / 7 LEU A  12
SER A  10
PHE A   9
ALA A 167
 None
 0.72A 1j8uA-4itmA:
undetectable		 1j8uA-4itmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		3 / 3 ARG A 171
GLY A  42
ASP A 139
 None
 0.59A 1kf6A-4itmA:
undetectable
1kf6B-4itmA:
undetectable		 1kf6A-4itmA:
19.11
1kf6B-4itmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 306
LEU A 309
ILE A 310
ILE A 313
LEU A  58
 None
 0.95A 1xdkF-4itmA:
undetectable		 1xdkF-4itmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		3 / 3 SER A 131
HIS A 110
ASP A  60
 None
 0.78A 2wa2B-4itmA:
undetectable		 2wa2B-4itmA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		4 / 6 TYR A 275
PHE A 232
MET A 256
PHE A 258
 None
 1.33A 3af3A-4itmA:
4.3		 3af3A-4itmA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		3 / 3 SER A 233
GLY A 236
GLY A 239
 None
 0.41A 3bogA-4itmA:
undetectable
3bogC-4itmA:
undetectable		 3bogA-4itmA:
undetectable
3bogC-4itmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		5 / 9 LEU A  34
LEU A 146
ILE A 310
PHE A 135
VAL A 134
 None
 1.24A 3tmzA-4itmA:
undetectable		 3tmzA-4itmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		4 / 7 LEU A  58
VAL A 184
LEU A 306
TYR A  57
 None
 0.89A 4b3qA-4itmA:
undetectable		 4b3qA-4itmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		3 / 3 LYS A 308
TYR A 311
ARG A 312
 None
 1.27A 4gc9A-4itmA:
undetectable		 4gc9A-4itmA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		4 / 7 ASN A 238
TYR A 275
LEU A 276
PHE A 292
 None
 1.21A 4yv5B-4itmA:
undetectable		 4yv5B-4itmA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4itm TETRAACYLDISACCHARID
E 4'-KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 306
LEU A 309
ILE A 310
LEU A  58
VAL A 184
 None
 1.31A 5uanB-4itmA:
undetectable		 5uanB-4itmA:
19.90