SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4itx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 GLY A 255
LEU A  67
MET A  71
LEU A   6
LEU A 263
 None
 1.05A 1fm6D-4itxA:
undetectable		 1fm6D-4itxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 HIS A 297
GLY A 296
GLU A 298
GLY A 293
ASP A 165
 None
 1.13A 1n2xA-4itxA:
6.1		 1n2xA-4itxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.38A 1q23C-4itxA:
2.5		 1q23C-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.31A 1q23F-4itxA:
2.5		 1q23F-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.37A 1q23I-4itxA:
2.5		 1q23I-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.37A 1q23L-4itxA:
2.5		 1q23L-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		6 / 12 ILE A 136
LEU A 105
PHE A 132
ILE A 182
LEU A 153
ILE A 169
 None
 1.46A 2d0kB-4itxA:
undetectable		 2d0kB-4itxA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 PHE A 132
VAL A 151
ILE A 182
PHE A 194
PHE A 304
 None
 1.21A 3apwA-4itxA:
undetectable		 3apwA-4itxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		3 / 3 ASP A 386
LEU A 387
GLN A 282
 None
 0.79A 3g4lA-4itxA:
undetectable		 3g4lA-4itxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 ILE A 159
SER A 158
GLY A 157
THR A 109
GLU A 154
 None
IN5  A 401 ( 4.0A)
None
None
IN5  A 401 (-3.7A)
 1.49A 3r75A-4itxA:
undetectable		 3r75A-4itxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 ILE A 159
SER A 158
GLY A 157
THR A 109
GLU A 154
 None
IN5  A 401 ( 4.0A)
None
None
IN5  A 401 (-3.7A)
 1.49A 3r75B-4itxA:
undetectable		 3r75B-4itxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 ILE A 159
SER A 158
GLY A 157
THR A 109
GLU A 154
 None
IN5  A 401 ( 4.0A)
None
None
IN5  A 401 (-3.7A)
 1.48A 3r76A-4itxA:
undetectable		 3r76A-4itxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 ILE A 159
SER A 158
GLY A 157
THR A 109
GLU A 154
 None
IN5  A 401 ( 4.0A)
None
None
IN5  A 401 (-3.7A)
 1.48A 3r76B-4itxA:
undetectable		 3r76B-4itxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.27A 3u9fB-4itxA:
2.5
3u9fC-4itxA:
2.4		 3u9fB-4itxA:
22.00
3u9fC-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 10 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.33A 3u9fE-4itxA:
2.6		 3u9fE-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 10 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.34A 3u9fD-4itxA:
2.5
3u9fF-4itxA:
undetectable		 3u9fD-4itxA:
22.00
3u9fF-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.31A 3u9fH-4itxA:
2.4
3u9fI-4itxA:
2.5		 3u9fH-4itxA:
22.00
3u9fI-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.29A 3u9fJ-4itxA:
undetectable
3u9fK-4itxA:
undetectable		 3u9fJ-4itxA:
22.00
3u9fK-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 10 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.32A 3u9fK-4itxA:
undetectable		 3u9fK-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.29A 3u9fM-4itxA:
undetectable
3u9fO-4itxA:
2.5		 3u9fM-4itxA:
22.00
3u9fO-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 10 TYR A 327
PHE A 331
VAL A 286
PHE A 311
VAL A 273
 None
 1.32A 3u9fR-4itxA:
2.4		 3u9fR-4itxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		4 / 7 LEU A 193
TYR A 211
SER A 307
HIS A 267
 None
 1.38A 4arcA-4itxA:
undetectable		 4arcA-4itxA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		4 / 6 ALA A 237
ASN A 236
LEU A 233
GLU A  99
 None
 0.80A 4g24A-4itxA:
undetectable		 4g24A-4itxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.31A 4qvmV-4itxA:
undetectable
4qvmb-4itxA:
undetectable		 4qvmV-4itxA:
20.42
4qvmb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.31A 4qvmH-4itxA:
undetectable
4qvmN-4itxA:
undetectable		 4qvmH-4itxA:
20.42
4qvmN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.26A 4qvnV-4itxA:
undetectable
4qvnb-4itxA:
undetectable		 4qvnV-4itxA:
20.42
4qvnb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.29A 4qvpV-4itxA:
undetectable
4qvpb-4itxA:
undetectable		 4qvpV-4itxA:
20.42
4qvpb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.28A 4qvpH-4itxA:
undetectable
4qvpN-4itxA:
undetectable		 4qvpH-4itxA:
20.42
4qvpN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.28A 4qvqV-4itxA:
undetectable
4qvqb-4itxA:
undetectable		 4qvqV-4itxA:
20.42
4qvqb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.29A 4qvqH-4itxA:
undetectable
4qvqN-4itxA:
undetectable		 4qvqH-4itxA:
20.42
4qvqN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.30A 4qvwV-4itxA:
undetectable
4qvwb-4itxA:
undetectable		 4qvwV-4itxA:
20.42
4qvwb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.30A 4qvwH-4itxA:
undetectable
4qvwN-4itxA:
undetectable		 4qvwH-4itxA:
20.42
4qvwN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.31A 4qw0V-4itxA:
undetectable
4qw0b-4itxA:
undetectable		 4qw0V-4itxA:
20.42
4qw0b-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.30A 4qw0H-4itxA:
undetectable
4qw0N-4itxA:
undetectable		 4qw0H-4itxA:
20.42
4qw0N-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.27A 4qw1V-4itxA:
undetectable
4qw1b-4itxA:
undetectable		 4qw1V-4itxA:
20.42
4qw1b-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.28A 4qw1H-4itxA:
undetectable
4qw1N-4itxA:
undetectable		 4qw1H-4itxA:
20.42
4qw1N-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.29A 4qw3V-4itxA:
undetectable
4qw3b-4itxA:
undetectable		 4qw3V-4itxA:
20.42
4qw3b-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.29A 4qw3H-4itxA:
undetectable
4qw3N-4itxA:
undetectable		 4qw3H-4itxA:
20.42
4qw3N-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.25A 4qwuV-4itxA:
undetectable
4qwub-4itxA:
undetectable		 4qwuV-4itxA:
20.42
4qwub-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.25A 4qwuH-4itxA:
undetectable
4qwuN-4itxA:
undetectable		 4qwuH-4itxA:
20.42
4qwuN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 PHE A 331
LEU A 277
ALA A 385
ASP A 386
PHE A 313
 None
 1.38A 4wnuC-4itxA:
undetectable		 4wnuC-4itxA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		4 / 7 TYR A 111
ARG A 372
SER A 158
GLU A 154
 IN5  A 401 (-3.6A)
IN5  A 401 (-2.9A)
IN5  A 401 ( 4.0A)
IN5  A 401 (-3.7A)
 1.28A 4xzkA-4itxA:
undetectable		 4xzkA-4itxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 ALA A 249
THR A 252
LEU A  67
THR A 222
GLY A  60
 None
 1.21A 4ypmA-4itxA:
undetectable		 4ypmA-4itxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.31A 5cz7H-4itxA:
undetectable
5cz7N-4itxA:
undetectable		 5cz7H-4itxA:
20.42
5cz7N-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.30A 5d0xV-4itxA:
undetectable
5d0xb-4itxA:
undetectable		 5d0xV-4itxA:
20.42
5d0xb-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.31A 5d0xH-4itxA:
undetectable
5d0xN-4itxA:
undetectable		 5d0xH-4itxA:
20.42
5d0xN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		4 / 6 ALA A 208
THR A 209
VAL A 213
VAL A 244
 None
IN5  A 401 (-3.0A)
None
None
 0.87A 5eclD-4itxA:
undetectable		 5eclD-4itxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 10 ASP A 202
ARG A 174
LEU A 233
PHE A  97
ILE A 169
 None
 1.34A 5hw8C-4itxA:
undetectable
5hw8H-4itxA:
undetectable		 5hw8C-4itxA:
14.89
5hw8H-4itxA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 12 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.29A 5l5zH-4itxA:
undetectable
5l5zN-4itxA:
undetectable		 5l5zH-4itxA:
20.42
5l5zN-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.27A 5l66V-4itxA:
undetectable
5l66b-4itxA:
undetectable		 5l66V-4itxA:
20.42
5l66b-4itxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4itx CYSTATHIONINE
BETA-LYASE METC
(Escherichia
coli) 		5 / 11 SER A 114
THR A 160
GLY A 157
ALA A 110
THR A 107
 None
 1.27A 5l66H-4itxA:
undetectable
5l66N-4itxA:
undetectable		 5l66H-4itxA:
20.42
5l66N-4itxA:
21.20