SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 12 ASP A 118
THR B 214
GLY B 133
VAL B 131
ALA A 117
 None
 1.18A 1nw5A-4iu2A:
undetectable		 1nw5A-4iu2A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens) 		3 / 3 ALA A  67
THR B 137
PHE A 160
 None
 0.63A 2c6nB-4iu2A:
undetectable		 2c6nB-4iu2A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens) 		4 / 7 VAL A 130
ASN A 106
VAL A 113
ASP B 219
 None
 0.93A 2y05A-4iu2A:
undetectable
2y05B-4iu2A:
undetectable		 2y05A-4iu2A:
22.12
2y05B-4iu2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 12 GLN A 173
GLY A  70
ARG B 134
TYR A  19
LEU A  21
 None
None
SO4  A 302 (-3.2A)
None
None
 1.41A 3iizA-4iu2A:
undetectable		 3iizA-4iu2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 12 GLN A 173
GLY A  70
ARG B 134
TYR A  19
LEU A  21
 None
None
SO4  A 302 (-3.2A)
None
None
 1.38A 4jxcA-4iu2A:
undetectable		 4jxcA-4iu2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		3 / 3 TYR A  19
THR A  18
THR A 178
 None
 0.67A 5aoxB-4iu2A:
undetectable		 5aoxB-4iu2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		3 / 3 TYR A  19
THR A  18
THR A 178
 None
 0.70A 5aoxE-4iu2A:
undetectable		 5aoxE-4iu2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 LEU A  79
ILE A 146
HIS A  72
VAL A 130
VAL A  55
 None
 1.12A 5dpdA-4iu2A:
undetectable		 5dpdA-4iu2A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4iu2 CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens) 		4 / 7 ALA B 225
TYR B 221
VAL B 236
LYS B 231
 None
 1.20A 5ecnA-4iu2B:
undetectable		 5ecnA-4iu2B:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		3 / 3 HIS A   7
HIS A   5
HIS A   4
 SO4  A 305 (-3.6A)
None
None
 0.96A 5oexA-4iu2A:
undetectable		 5oexA-4iu2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 12 LEU A 159
THR A  68
GLY A 116
GLY B 123
ILE B 130
 None
 1.21A 5tuiB-4iu2A:
undetectable		 5tuiB-4iu2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4iu2 CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 PHE B  24
PHE B  26
LEU B 179
LEU B 190
 None
 1.12A 5veuH-4iu2B:
undetectable		 5veuH-4iu2B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		4 / 7 ALA A 196
ILE A 205
VAL A 143
PRO A 135
 SO4  A 308 ( 3.8A)
None
SO4  A 308 (-4.2A)
None
 0.92A 6cduF-4iu2A:
undetectable
6cduJ-4iu2A:
2.4		 6cduF-4iu2A:
21.05
6cduJ-4iu2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4iu2 CELLULOSE-BINDING
PROTEIN
(Ruminococcus
flavefaciens) 		4 / 6 TYR B 118
VAL B  21
VAL B 115
THR B 116
 None
 1.45A 6f32B-4iu2B:
undetectable		 6f32B-4iu2B:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4iu2 CELL-WALL ANCHORING
PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 ASP A  14
ASN A 107
HIS A  72
TYR A  74
ASN A 109
 None
 1.33A 6mxtA-4iu2A:
undetectable		 6mxtA-4iu2A:
18.78