SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.00A 1c9sP-4iu6A:
undetectable
1c9sQ-4iu6A:
undetectable		 1c9sP-4iu6A:
12.50
1c9sQ-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.02A 1gtfJ-4iu6A:
undetectable
1gtfK-4iu6A:
undetectable		 1gtfJ-4iu6A:
12.50
1gtfK-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 0.99A 1gtfQ-4iu6A:
undetectable
1gtfR-4iu6A:
undetectable		 1gtfQ-4iu6A:
12.50
1gtfR-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 0.98A 1gtfS-4iu6A:
undetectable
1gtfT-4iu6A:
undetectable		 1gtfS-4iu6A:
12.50
1gtfT-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.00A 1gtnT-4iu6A:
undetectable
1gtnU-4iu6A:
undetectable		 1gtnT-4iu6A:
12.50
1gtnU-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.01A 1gtnL-4iu6A:
undetectable
1gtnV-4iu6A:
undetectable		 1gtnL-4iu6A:
12.50
1gtnV-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 4 ASP A 160
HIS A 390
ARG A 383
GLU A 243
 None
 1.25A 1lqtA-4iu6A:
undetectable		 1lqtA-4iu6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.02A 1utdE-4iu6A:
undetectable
1utdF-4iu6A:
undetectable		 1utdE-4iu6A:
12.50
1utdF-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.01A 1utdH-4iu6A:
undetectable
1utdI-4iu6A:
undetectable		 1utdH-4iu6A:
12.50
1utdI-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 0.98A 1utdL-4iu6A:
undetectable
1utdM-4iu6A:
undetectable		 1utdL-4iu6A:
12.50
1utdM-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.00A 1utdO-4iu6A:
undetectable
1utdP-4iu6A:
undetectable		 1utdO-4iu6A:
12.50
1utdP-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 239
HIS A 238
THR A 334
THR A 369
GLY A 304
 None
None
CO  A 401 (-3.5A)
None
None
 1.00A 1utdS-4iu6A:
undetectable
1utdT-4iu6A:
undetectable		 1utdS-4iu6A:
12.50
1utdT-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.00A 1utdL-4iu6A:
undetectable
1utdV-4iu6A:
undetectable		 1utdL-4iu6A:
12.50
1utdV-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 LEU A 181
ALA A 185
ILE A 184
VAL A 158
ALA A 155
 None
 1.12A 1xp0A-4iu6A:
undetectable		 1xp0A-4iu6A:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 CYH A 203
HIS A 212
HIS A 310
TRP A 353
 FZ1  A 405 (-3.5A)
CO  A 403 ( 3.1A)
FZ1  A 405 (-3.4A)
None
 0.73A 1yvmA-4iu6A:
38.7		 1yvmA-4iu6A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 TYR A 195
CYH A 203
HIS A 212
HIS A 310
 FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.5A)
CO  A 403 ( 3.1A)
FZ1  A 405 (-3.4A)
 0.44A 1yvmA-4iu6A:
38.7		 1yvmA-4iu6A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 THR A 311
GLY A 304
GLY A 302
THR A 334
GLU A 367
 None
None
None
CO  A 401 (-3.5A)
CO  A 401 ( 2.3A)
 1.28A 2akeA-4iu6A:
undetectable		 2akeA-4iu6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 THR A 311
GLY A 304
GLY A 302
THR A 334
GLU A 367
 None
None
None
CO  A 401 (-3.5A)
CO  A 401 ( 2.3A)
 1.31A 2azxA-4iu6A:
undetectable		 2azxA-4iu6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 THR A 311
GLY A 304
GLY A 302
THR A 334
GLU A 367
 None
None
None
CO  A 401 (-3.5A)
CO  A 401 ( 2.3A)
 1.30A 2azxB-4iu6A:
undetectable		 2azxB-4iu6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 GLN A 113
ASP A 116
TYR A 237
SER A 127
 None
 1.24A 2xz5C-4iu6A:
undetectable
2xz5D-4iu6A:
undetectable		 2xz5C-4iu6A:
17.92
2xz5D-4iu6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 SER A 295
GLY A 343
SER A 363
 None
 0.54A 3loqA-4iu6A:
undetectable		 3loqA-4iu6A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 LEU A 265
GLY A 304
ILE A 305
ILE A 269
ILE A 335
 None
 1.11A 3s56B-4iu6A:
undetectable		 3s56B-4iu6A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 317
SER A 363
ASN A 242
 None
 0.78A 3s8pB-4iu6A:
undetectable		 3s8pB-4iu6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.4A)
None
 1.24A 3uzzA-4iu6A:
undetectable		 3uzzA-4iu6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.4A)
None
 1.32A 3uzzB-4iu6A:
undetectable		 3uzzB-4iu6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 ASP A 160
ASP A 385
SER A 386
HIS A 390
 None
 1.25A 4k7gB-4iu6A:
undetectable		 4k7gB-4iu6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 4 LEU A 140
ILE A 305
HIS A 306
VAL A 332
 None
 1.15A 4xyzA-4iu6A:
undetectable		 4xyzA-4iu6A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 317
SER A 363
ASN A 242
 None
 0.84A 5cprB-4iu6A:
undetectable		 5cprB-4iu6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5eevA-4iu6A:
undetectable
5eevB-4iu6A:
undetectable		 5eevA-4iu6A:
12.50
5eevB-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5eewA-4iu6A:
undetectable
5eewB-4iu6A:
undetectable		 5eewA-4iu6A:
12.50
5eewB-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5eexA-4iu6A:
undetectable
5eexB-4iu6A:
undetectable		 5eexA-4iu6A:
12.50
5eexB-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5eeyA-4iu6A:
undetectable
5eeyB-4iu6A:
undetectable		 5eeyA-4iu6A:
12.50
5eeyB-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5eezA-4iu6A:
undetectable
5eezB-4iu6A:
undetectable		 5eezA-4iu6A:
12.50
5eezB-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5ef0A-4iu6A:
undetectable
5ef0B-4iu6A:
undetectable		 5ef0A-4iu6A:
12.50
5ef0B-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5ef1A-4iu6A:
undetectable
5ef1B-4iu6A:
undetectable		 5ef1A-4iu6A:
12.50
5ef1B-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5ef2A-4iu6A:
undetectable
5ef2B-4iu6A:
undetectable		 5ef2A-4iu6A:
12.50
5ef2B-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.03A 5ef3A-4iu6A:
undetectable
5ef3B-4iu6A:
undetectable		 5ef3A-4iu6A:
12.50
5ef3B-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLY A 302
HIS A 303
ASP A 240
HIS A 212
 None
CO  A 401 (-3.1A)
CO  A 402 ( 2.2A)
CO  A 403 ( 3.1A)
 0.76A 5nnwD-4iu6A:
undetectable		 5nnwD-4iu6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLY A 302
HIS A 303
ASP A 240
HIS A 212
 None
CO  A 401 (-3.1A)
CO  A 402 ( 2.2A)
CO  A 403 ( 3.1A)
 0.79A 5no9D-4iu6A:
undetectable		 5no9D-4iu6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 ASP A 229
ALA A 364
ARG A 383
PRO A 337
LEU A 265
 CO  A 402 (-1.9A)
None
None
None
None
 1.28A 5syfB-4iu6A:
undetectable		 5syfB-4iu6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 THR A 244
THR A 172
HIS A  99
LEU A  96
 None
None
SO4  A 406 (-4.1A)
SO4  A 406 (-4.6A)
 1.30A 5utuH-4iu6A:
undetectable		 5utuH-4iu6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 ILE A 145
GLY A 330
LEU A 139
GLY A 304
ARG A 149
 None
 1.16A 6nm4B-4iu6A:
undetectable		 6nm4B-4iu6A:
19.15