SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 ILE B 309
GLY B 362
ALA B 263
GLY B 315
LEU B 449
 None
 1.13A 1kiaC-4iu9B:
undetectable		 1kiaC-4iu9B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 SER B 272
VAL B 176
GLY B 299
GLY B 295
 None
 0.76A 1tnlA-4iu9B:
undetectable		 1tnlA-4iu9B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 TRP B 116
LEU B 136
GLY B 139
PHE B 140
VAL B 133
 None
 1.13A 1tsnA-4iu9B:
undetectable		 1tsnA-4iu9B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 TRP B  50
GLY B 266
PHE B 268
SER B 267
 None
 1.09A 2a3cA-4iu9B:
undetectable		 2a3cA-4iu9B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 TRP B  50
GLY B 266
PHE B 268
SER B 267
 None
 1.16A 2a3cB-4iu9B:
undetectable		 2a3cB-4iu9B:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 VAL B 176
PHE B 356
GLY B 274
ALA B 273
SER B  54
 None
 1.09A 2aylA-4iu9B:
undetectable		 2aylA-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 7 LEU B 278
PHE B 275
GLY B 274
THR B  76
 None
 0.94A 2bdmA-4iu9B:
undetectable		 2bdmA-4iu9B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 LEU B 404
ILE B 407
ARG B 303
GLY B 364
 None
 0.84A 2du8A-4iu9B:
undetectable		 2du8A-4iu9B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 SER B 272
VAL B 176
GLY B 299
GLY B 295
 None
 0.76A 2otvA-4iu9B:
undetectable		 2otvA-4iu9B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 PHE B 271
GLY B 266
ALA B 263
VAL B  81
PRO B 419
 None
 1.12A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 PHE B 271
GLY B 414
GLY B 266
VAL B  81
PRO B 419
 None
 1.01A 2zulA-4iu9B:
undetectable		 2zulA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 GLY B 118
LEU B 117
PRO B 127
ASN B 123
VAL B 121
 None
 1.10A 3av6A-4iu9B:
undetectable		 3av6A-4iu9B:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		3 / 3 SER B  80
GLY B 414
GLY B 270
 None
 0.38A 3bogA-4iu9B:
undetectable
3bogC-4iu9B:
undetectable		 3bogA-4iu9B:
undetectable
3bogC-4iu9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 4 SER B 310
GLY B 315
GLY B 306
GLY B 362
 None
 0.89A 3bogB-4iu9B:
undetectable
3bogD-4iu9B:
undetectable		 3bogB-4iu9B:
undetectable
3bogD-4iu9B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 PHE B 271
GLY B 414
GLY B 266
VAL B  81
PRO B 419
 None
 1.01A 3dmfA-4iu9B:
undetectable		 3dmfA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		6 / 12 PHE B 271
GLY B 415
GLY B 266
ALA B 263
VAL B  81
PRO B 419
 None
 1.47A 3dmfA-4iu9B:
undetectable		 3dmfA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 PHE B 271
GLY B 414
GLY B 266
VAL B  81
PRO B 419
 None
 1.02A 3dmhA-4iu9B:
undetectable		 3dmhA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		6 / 12 PHE B 271
GLY B 415
GLY B 266
ALA B 263
VAL B  81
PRO B 419
 None
 1.48A 3dmhA-4iu9B:
undetectable		 3dmhA-4iu9B:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		3 / 3 MET B 424
MET B 277
PHE B 417
 None
 1.38A 3gn8A-4iu9B:
undetectable		 3gn8A-4iu9B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 8 SER B 363
PHE B 367
TYR B 261
LEU B 165
 None
 0.94A 3jq7B-4iu9B:
undetectable		 3jq7B-4iu9B:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 VAL B 176
PHE B 356
GLY B 274
ALA B 273
SER B  54
 None
 1.10A 3kk6A-4iu9B:
undetectable		 3kk6A-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 7 PHE B 422
GLY B 423
PHE B  73
PHE B 275
 None
 1.16A 3ko0D-4iu9B:
undetectable
3ko0E-4iu9B:
undetectable		 3ko0D-4iu9B:
11.26
3ko0E-4iu9B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 VAL B 176
ALA B 359
GLY B 274
ALA B 273
SER B  54
 None
 1.04A 3ln1A-4iu9B:
undetectable		 3ln1A-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 VAL B 176
ALA B 359
GLY B 274
ALA B 273
SER B  54
 None
 1.04A 3ln1B-4iu9B:
undetectable		 3ln1B-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 VAL B 176
ALA B 359
GLY B 274
ALA B 273
SER B  54
 None
 1.04A 3ln1C-4iu9B:
1.3		 3ln1C-4iu9B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 GLY B 270
GLY B 266
VAL B 413
ALA B  77
SER B 363
 None
 1.24A 3mteA-4iu9B:
undetectable		 3mteA-4iu9B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 9 PHE B  47
ALA B 141
PHE B 265
ASN B 144
PHE B 145
 None
 1.46A 3t3sA-4iu9B:
undetectable		 3t3sA-4iu9B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 GLY B 306
GLY B 360
TYR B 261
LEU B 257
ALA B 371
 None
 1.03A 3t7vA-4iu9B:
undetectable		 3t7vA-4iu9B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 10 GLY B 362
GLY B 364
PHE B 271
SER B 272
PHE B 356
 None
 0.94A 4fakA-4iu9B:
undetectable		 4fakA-4iu9B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 12 TRP B 229
GLY B  98
PHE B  97
VAL B 104
ALA B 228
 None
 1.24A 4fqsA-4iu9B:
undetectable		 4fqsA-4iu9B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		3 / 3 TYR B 261
ARG B  87
SER B 408
 None
 1.07A 4khpI-4iu9B:
undetectable
4khpJ-4iu9B:
undetectable		 4khpI-4iu9B:
12.26
4khpJ-4iu9B:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 5 ARG B  87
GLY B 142
ALA B 143
GLY B 139
 None
 0.96A 4u9uB-4iu9B:
undetectable		 4u9uB-4iu9B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 5 PHE B 345
PRO B 284
VAL B 286
ALA B 279
 None
 1.18A 4w5oA-4iu9B:
undetectable		 4w5oA-4iu9B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 11 PHE B 439
GLY B 354
ALA B 327
SER B 330
PHE B 352
 None
 1.19A 4wnuC-4iu9B:
undetectable		 4wnuC-4iu9B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		5 / 9 PRO B 296
LEU B 174
GLY B 175
ILE B 298
MET B 353
 None
 1.34A 4x3mA-4iu9B:
undetectable		 4x3mA-4iu9B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 5 PHE B 345
PRO B 284
VAL B 286
ALA B 279
 None
 1.19A 4z4cA-4iu9B:
undetectable		 4z4cA-4iu9B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 5 PHE B 345
PRO B 284
VAL B 286
ALA B 279
 None
 1.20A 4z4dA-4iu9B:
undetectable		 4z4dA-4iu9B:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 PHE B 345
PRO B 284
VAL B 286
ALA B 279
 None
 1.16A 5t7bA-4iu9B:
undetectable		 5t7bA-4iu9B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 ARG B 317
PHE B 325
PHE B 323
THR B 264
 None
 1.08A 5vceA-4iu9B:
undetectable		 5vceA-4iu9B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4iu9 NITRITE EXTRUSION
PROTEIN 2
(Escherichia
coli) 		4 / 6 PHE B  53
LEU B  75
ALA B 135
THR B 126
 None
 0.93A 6f88A-4iu9B:
undetectable		 6f88A-4iu9B:
12.31