SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		3 / 3 GLN A 151
HIS A 159
PRO A 195
 None
 0.89A 1d8cA-4iuaA:
undetectable		 1d8cA-4iuaA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		3 / 3 GLU A 282
GLU A 228
TRP A 281
 None
 1.07A 3hrdA-4iuaA:
undetectable
3hrdE-4iuaA:
undetectable
3hrdF-4iuaA:
undetectable		 3hrdA-4iuaA:
20.53
3hrdE-4iuaA:
20.53
3hrdF-4iuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 7 PHE A  88
GLU A  70
SER A  67
VAL A  65
 None
 1.42A 4k5jA-4iuaA:
undetectable
4k5jB-4iuaA:
undetectable		 4k5jA-4iuaA:
18.65
4k5jB-4iuaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 7 PHE A  88
GLU A  70
SER A  67
VAL A  65
 None
 1.44A 5vv7A-4iuaA:
undetectable
5vv7B-4iuaA:
undetectable		 5vv7A-4iuaA:
18.65
5vv7B-4iuaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 5 LEU A 119
PHE A 117
LEU A  51
PHE A 102
 None
 1.28A 5xdxP-4iuaA:
undetectable
5xdxW-4iuaA:
undetectable		 5xdxP-4iuaA:
18.06
5xdxW-4iuaA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 7 SER A  67
VAL A  65
PHE A  88
GLU A  70
 None
 1.46A 6av6A-4iuaA:
undetectable
6av6B-4iuaA:
undetectable		 6av6A-4iuaA:
13.68
6av6B-4iuaA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 7 SER A  67
VAL A  65
PHE A  88
GLU A  70
 None
 1.44A 6av7A-4iuaA:
undetectable
6av7B-4iuaA:
undetectable		 6av7A-4iuaA:
13.68
6av7B-4iuaA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 8 HIS A 244
ARG A 235
HIS A  41
ASP A 237
 None
 1.12A 6mn4A-4iuaA:
undetectable		 6mn4A-4iuaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4iua HEPATOCYTE GROWTH
FACTOR
(Mus
musculus) 		4 / 7 HIS A 244
ARG A 235
HIS A  41
ASP A 237
 None
 1.10A 6mn4F-4iuaA:
undetectable		 6mn4F-4iuaA:
18.18