SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 10 PRO A  73
VAL A  74
VAL A 945
PRO A 993
GLY A 948
 None
 1.10A 13gsA-4iugA:
undetectable		 13gsA-4iugA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 9 PRO A  73
VAL A  74
VAL A 945
PRO A 993
GLY A 948
 None
 1.10A 13gsB-4iugA:
undetectable		 13gsB-4iugA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 TRP A 307
GLY A 308
ASN A 936
PRO A 310
 None
NAG  A1149 (-3.4A)
None
MAN  A1153 (-3.7A)
 1.20A 1dedA-4iugA:
9.8		 1dedA-4iugA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.78A 1eizA-4iugA:
undetectable		 1eizA-4iugA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.77A 1ej0A-4iugA:
undetectable		 1ej0A-4iugA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 ARG A  71
ASN A 199
TYR A 260
ASN A 235
 None
GAL  A1130 (-3.5A)
GAL  A1130 (-4.5A)
GAL  A1130 (-4.6A)
 1.50A 1f9gA-4iugA:
undetectable		 1f9gA-4iugA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 PHE A 148
TRP A  99
GLU A 103
 None
 1.05A 1mogA-4iugA:
undetectable		 1mogA-4iugA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 10 SER A 394
ASP A 476
LEU A 447
THR A 404
TYR A 408
 None
 1.26A 1mxfA-4iugA:
0.3		 1mxfA-4iugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 SER A 394
ASP A 476
LEU A 447
THR A 404
TYR A 408
 None
 1.28A 1mxfB-4iugA:
2.4		 1mxfB-4iugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 SER A 394
ASP A 476
LEU A 447
THR A 404
TYR A 408
 None
 1.29A 1mxfC-4iugA:
undetectable		 1mxfC-4iugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 SER A 394
ASP A 476
LEU A 447
THR A 404
TYR A 408
 None
 1.28A 1mxfD-4iugA:
undetectable		 1mxfD-4iugA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 TYR A 930
ASN A 956
TYR A 952
GLY A 954
 None
 1.27A 1mxgA-4iugA:
8.5		 1mxgA-4iugA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 9 LEU A 965
ALA A 970
GLY A 935
LEU A 960
LEU A 962
 None
None
NAG  A1148 (-4.1A)
None
None
 1.16A 1nr6A-4iugA:
undetectable		 1nr6A-4iugA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.16A 1r15C-4iugA:
undetectable		 1r15C-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.16A 1r15D-4iugA:
undetectable		 1r15D-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.15A 1r15E-4iugA:
1.9		 1r15E-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 GLU A 322
ASN A 320
TRP A 272
 CD  A1114 ( 2.5A)
MAN  A1142 (-3.8A)
None
 1.12A 1r15F-4iugA:
2.0		 1r15F-4iugA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 SER A 756
TRP A 963
LEU A 683
GLU A 685
 None
 1.00A 2cdqB-4iugA:
undetectable		 2cdqB-4iugA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 1.05A 2cmlA-4iugA:
undetectable		 2cmlA-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 0.97A 2cmlB-4iugA:
undetectable		 2cmlB-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 1.03A 2cmlC-4iugA:
undetectable		 2cmlC-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 1.10A 2cmlD-4iugA:
undetectable		 2cmlD-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 10 TYR A 260
TYR A 362
TYR A  96
GLY A 146
ALA A 141
 GAL  A1130 (-4.5A)
None
GAL  A1130 (-4.7A)
None
GAL  A1130 (-4.5A)
 1.34A 2coiA-4iugA:
undetectable
2coiB-4iugA:
undetectable		 2coiA-4iugA:
17.51
2coiB-4iugA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 LEU A 610
LEU A 615
PRO A 576
VAL A 599
 None
 1.10A 2dqyC-4iugA:
undetectable		 2dqyC-4iugA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.47A 2dysA-4iugA:
undetectable
2dysC-4iugA:
undetectable		 2dysA-4iugA:
19.33
2dysC-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.48A 2eikA-4iugA:
undetectable
2eikC-4iugA:
undetectable		 2eikA-4iugA:
19.33
2eikC-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.46A 2eilA-4iugA:
undetectable
2eilC-4iugA:
undetectable		 2eilA-4iugA:
19.33
2eilC-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.49A 2eimA-4iugA:
undetectable
2eimC-4iugA:
undetectable		 2eimA-4iugA:
19.33
2eimC-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 10 THR A 360
THR A 934
ALA A 921
SER A 961
GLN A 929
 None
 1.33A 2ij7D-4iugA:
undetectable		 2ij7D-4iugA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 10 THR A 360
THR A 934
ALA A 921
SER A 961
GLN A 929
 None
 1.31A 2ij7F-4iugA:
undetectable		 2ij7F-4iugA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 LEU A 503
VAL A 555
ILE A 533
GLY A 545
VAL A 562
 None
 0.67A 2nnpB-4iugA:
undetectable		 2nnpB-4iugA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 LEU A 669
PRO A 670
LEU A 977
 None
 0.49A 2qd5B-4iugA:
undetectable		 2qd5B-4iugA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 GLU A 804
TYR A 342
ILE A 139
VAL A 143
TYR A  96
 CD  A1108 (-2.3A)
GAL  A1130 (-4.2A)
None
None
GAL  A1130 (-4.7A)
 1.43A 2qeoA-4iugA:
undetectable		 2qeoA-4iugA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ASP A 620
ILE A 368
ILE A  81
ASP A  80
ASP A 905
 None
 1.28A 2qmjA-4iugA:
5.8		 2qmjA-4iugA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 GLY A 927
GLY A 931
GLN A 922
PHE A 891
 None
 1.02A 2qx6A-4iugA:
undetectable
2qx6B-4iugA:
undetectable		 2qx6A-4iugA:
12.85
2qx6B-4iugA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 ILE A 797
GLY A 801
GLY A 750
GLN A 748
 None
None
CD  A1103 ( 4.8A)
None
 0.77A 2wd9B-4iugA:
2.1		 2wd9B-4iugA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.46A 3abkA-4iugA:
undetectable
3abkC-4iugA:
undetectable		 3abkA-4iugA:
19.33
3abkC-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.46A 3abkN-4iugA:
undetectable
3abkP-4iugA:
undetectable		 3abkN-4iugA:
19.33
3abkP-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.46A 3ag1A-4iugA:
undetectable
3ag1C-4iugA:
undetectable		 3ag1A-4iugA:
19.33
3ag1C-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.47A 3ag2A-4iugA:
undetectable
3ag2C-4iugA:
undetectable		 3ag2A-4iugA:
19.33
3ag2C-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.47A 3ag3A-4iugA:
undetectable
3ag3C-4iugA:
undetectable		 3ag3A-4iugA:
19.33
3ag3C-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.46A 3ag3N-4iugA:
undetectable
3ag3P-4iugA:
undetectable		 3ag3N-4iugA:
19.33
3ag3P-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 HIS A 473
ASP A 410
THR A 409
HIS A 513
 None
CD  A1115 ( 2.6A)
None
None
 1.48A 3ag4A-4iugA:
undetectable
3ag4C-4iugA:
undetectable		 3ag4A-4iugA:
19.33
3ag4C-4iugA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 100
GLY A 354
GLY A 146
GLY A 147
LEU A 800
 None
 0.80A 3douA-4iugA:
undetectable		 3douA-4iugA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 GLY A 726
GLU A 861
GLY A 857
ASN A 352
 None
 1.12A 3e9rC-4iugA:
undetectable		 3e9rC-4iugA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 4 PRO A 457
THR A 455
GLY A 406
THR A 405
 None
 0.97A 3ib1A-4iugA:
undetectable		 3ib1A-4iugA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 LYS A 932
GLY A 754
THR A 934
ASP A 798
ILE A 797
 None
 1.04A 3id5B-4iugA:
undetectable		 3id5B-4iugA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 LYS A 932
GLY A 754
THR A 934
ASP A 798
ILE A 797
 None
 1.04A 3id5F-4iugA:
undetectable		 3id5F-4iugA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 PRO A 135
PHE A 232
ALA A 223
 None
 0.59A 3itaD-4iugA:
undetectable		 3itaD-4iugA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 PHE A 388
TYR A 395
THR A 397
PHE A 427
 None
 1.35A 3ltwA-4iugA:
undetectable		 3ltwA-4iugA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 9 ASP A  98
GLY A 147
ALA A 100
GLY A 801
LEU A 101
 None
 1.05A 3ogpB-4iugA:
undetectable		 3ogpB-4iugA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ASP A 620
ILE A 368
ILE A  81
ASP A  80
ASP A 905
 None
 1.33A 3phaA-4iugA:
6.9		 3phaA-4iugA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ASP A 620
ILE A 368
ILE A  81
ASP A  80
ASP A 905
 None
 1.31A 3phaB-4iugA:
6.9		 3phaB-4iugA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 PHE A 910
PHE A 975
PHE A 896
ALA A 894
 None
 0.90A 3t3sD-4iugA:
undetectable		 3t3sD-4iugA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 TYR A 362
GLY A 354
GLY A 358
TYR A 359
ALA A 100
 None
 1.04A 3vywC-4iugA:
undetectable		 3vywC-4iugA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 619
PHE A 621
ILE A 368
ASP A  80
ASP A 620
 None
 1.36A 3wemA-4iugA:
5.7		 3wemA-4iugA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 619
PHE A 621
ILE A 368
ASP A  80
ASP A 620
 None
 1.35A 3weoA-4iugA:
5.7		 3weoA-4iugA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 LEU A 560
LEU A 503
LEU A 505
ILE A 544
ILE A 484
 None
 0.94A 4a7aB-4iugA:
undetectable		 4a7aB-4iugA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 TYR A 957
VAL A 925
ILE A 949
ASN A 926
 None
 1.10A 4a97C-4iugA:
undetectable		 4a97C-4iugA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 VAL A 925
PHE A 912
GLY A 931
PHE A 975
 None
 0.99A 4ejjB-4iugA:
undetectable		 4ejjB-4iugA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 GLY A 145
GLY A 146
TYR A 138
ASN A 140
 None
None
None
CD  A1108 ( 3.1A)
 0.89A 4fgkB-4iugA:
undetectable		 4fgkB-4iugA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 ARG A  71
HIS A  68
TYR A 362
 None
 1.23A 4fu8A-4iugA:
undetectable		 4fu8A-4iugA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 GLU A  66
HIS A  68
PRO A  69
VAL A  93
 None
 1.12A 4hvrA-4iugA:
undetectable		 4hvrA-4iugA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ASN A 989
ARG A 953
ASN A 956
ASN A 926
GLN A 995
 None
 1.41A 4kuoA-4iugA:
undetectable		 4kuoA-4iugA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 THR A 348
GLY A 346
HIS A  68
ASN A 349
SER A 942
 None
None
None
None
NAG  A1132 (-3.6A)
 1.38A 4pooB-4iugA:
undetectable		 4pooB-4iugA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 GLY A 857
ASN A 352
ILE A 797
VAL A 795
ILE A 819
 None
 1.03A 4q5mA-4iugA:
undetectable		 4q5mA-4iugA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 632
THR A 625
VAL A 660
LEU A 639
LEU A 605
 None
 1.01A 4qynA-4iugA:
undetectable		 4qynA-4iugA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 ALA A 632
THR A 625
VAL A 660
LEU A 639
LEU A 605
 None
 1.03A 4qzuC-4iugA:
undetectable		 4qzuC-4iugA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 SER A 961
TYR A 924
ASP A 798
 None
 0.85A 4rp8C-4iugA:
undetectable		 4rp8C-4iugA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 TRP A  99
THR A 170
GLY A 145
LEU A 152
PRO A 149
 None
 1.45A 4uinH-4iugA:
undetectable
4uinL-4iugA:
undetectable		 4uinH-4iugA:
12.87
4uinL-4iugA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.37A 4v2yA-4iugA:
undetectable		 4v2yA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.44A 4v2yB-4iugA:
undetectable		 4v2yB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.37A 4v2zA-4iugA:
undetectable		 4v2zA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.41A 4v2zB-4iugA:
undetectable		 4v2zB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.37A 4v30A-4iugA:
undetectable		 4v30A-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.39A 4v30B-4iugA:
undetectable		 4v30B-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 GLU A 947
LEU A 908
TYR A 979
LEU A 898
LEU A 669
 None
 1.11A 4wg0K-4iugA:
undetectable
4wg0L-4iugA:
undetectable
4wg0M-4iugA:
undetectable		 4wg0K-4iugA:
1.78
4wg0L-4iugA:
1.78
4wg0M-4iugA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 PHE A 910
LEU A 950
LEU A 898
LEU A 900
TYR A 952
 None
 1.24A 4xumA-4iugA:
undetectable		 4xumA-4iugA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 TYR A  96
GLY A 136
GLU A 198
ASN A 199
 GAL  A1130 (-4.7A)
None
None
GAL  A1130 (-3.5A)
 1.12A 4zbqA-4iugA:
undetectable		 4zbqA-4iugA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 5 ALA A 570
TYR A 571
HIS A 432
PRO A 509
 SEP  A 569 ( 3.7A)
NAG  A1138 (-4.9A)
None
None
 1.10A 4ze2A-4iugA:
undetectable		 4ze2A-4iugA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.37A 5amhA-4iugA:
undetectable		 5amhA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.40A 5amiA-4iugA:
undetectable		 5amiA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.38A 5amiB-4iugA:
undetectable		 5amiB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.43A 5amjA-4iugA:
undetectable		 5amjA-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.42A 5amjB-4iugA:
undetectable		 5amjB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.39A 5amkB-4iugA:
undetectable		 5amkB-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 TYR A  96
GLU A 142
GLU A 200
GLU A 298
TYR A 342
 GAL  A1130 (-4.7A)
GAL  A1130 ( 2.8A)
GAL  A1130 (-2.4A)
GAL  A1130 (-2.4A)
GAL  A1130 (-4.2A)
 0.68A 5gsmA-4iugA:
31.2		 5gsmA-4iugA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 TYR A  96
GLU A 142
GLU A 200
GLU A 298
TYR A 342
 GAL  A1130 (-4.7A)
GAL  A1130 ( 2.8A)
GAL  A1130 (-2.4A)
GAL  A1130 (-2.4A)
GAL  A1130 (-4.2A)
 0.68A 5gsmB-4iugA:
32.1		 5gsmB-4iugA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 HIS A 473
LEU A 447
LEU A 445
THR A 411
 None
 1.18A 5hs6A-4iugA:
undetectable		 5hs6A-4iugA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 TYR A 930
VAL A  74
ILE A 114
PHE A  70
LEU A 353
 None
 1.23A 5huaA-4iugA:
undetectable		 5huaA-4iugA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 8 GLY A 818
THR A 747
LEU A 728
ASN A 799
 None
 1.04A 5hwaA-4iugA:
undetectable		 5hwaA-4iugA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 ASP A  80
ILE A  85
TYR A 379
TYR A 603
 None
None
None
NAG  A1137 (-4.7A)
 1.48A 5igyA-4iugA:
2.3		 5igyA-4iugA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.84A 5jsdA-4iugA:
undetectable		 5jsdA-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.85A 5jsdB-4iugA:
undetectable		 5jsdB-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.84A 5jsdC-4iugA:
undetectable		 5jsdC-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.84A 5jseA-4iugA:
1.8		 5jseA-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.83A 5jseB-4iugA:
undetectable		 5jseB-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		3 / 3 THR A 488
SER A 487
TYR A 486
 None
 0.83A 5jseC-4iugA:
undetectable		 5jseC-4iugA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 VAL A 479
VAL A 474
SER A 487
ILE A 456
 None
 1.07A 5jw1B-4iugA:
undetectable		 5jw1B-4iugA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 9 ILE A 174
VAL A 181
TRP A  99
ILE A  97
 None
 1.07A 5lg3I-4iugA:
undetectable		 5lg3I-4iugA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 9 TYR A 603
LEU A  72
TYR A 987
THR A 985
VAL A 983
 NAG  A1137 (-4.7A)
None
None
None
None
 1.40A 5mxbA-4iugA:
undetectable		 5mxbA-4iugA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.36A 5oh1A-4iugA:
undetectable		 5oh1A-4iugA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.39A 5oh1B-4iugA:
undetectable		 5oh1B-4iugA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.40A 5oh3A-4iugA:
undetectable		 5oh3A-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 PRO A  69
PHE A  70
TRP A 350
TYR A 930
 None
 1.42A 5oh3B-4iugA:
undetectable		 5oh3B-4iugA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 4 GLY A 508
PRO A 509
VAL A 548
ARG A 567
 None
None
None
MAN  A1141 ( 4.0A)
 1.36A 5uunA-4iugA:
0.2
5uunB-4iugA:
undetectable		 5uunA-4iugA:
15.24
5uunB-4iugA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 5 VAL A 319
PRO A 261
GLY A 263
TYR A 260
 None
None
None
GAL  A1130 (-4.5A)
 1.00A 5x80A-4iugA:
undetectable
5x80B-4iugA:
undetectable		 5x80A-4iugA:
10.46
5x80B-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 PRO A 261
GLY A 263
TYR A 260
LEU A 318
 None
None
GAL  A1130 (-4.5A)
None
 0.95A 5x80A-4iugA:
undetectable
5x80B-4iugA:
undetectable		 5x80A-4iugA:
10.46
5x80B-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 VAL A 319
PRO A 261
GLY A 263
TYR A 260
 None
None
None
GAL  A1130 (-4.5A)
 1.01A 5x80C-4iugA:
undetectable
5x80D-4iugA:
undetectable		 5x80C-4iugA:
10.46
5x80D-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 5 PRO A 261
GLY A 263
TYR A 260
VAL A 319
 None
None
GAL  A1130 (-4.5A)
None
 0.97A 5x80C-4iugA:
undetectable
5x80D-4iugA:
undetectable		 5x80C-4iugA:
10.46
5x80D-4iugA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 7 TRP A  48
SER A 295
GLY A 256
LEU A  53
 None
 1.14A 6btxA-4iugA:
undetectable		 6btxA-4iugA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 12 LEU A 503
VAL A 555
ILE A 533
GLY A 545
VAL A 562
 None
 0.76A 6dh0A-4iugA:
undetectable		 6dh0A-4iugA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 ASP A 803
GLN A 153
ASN A 705
SER A 718
 CD  A1103 (-2.3A)
None
None
None
 0.93A 6ekuA-4iugA:
undetectable		 6ekuA-4iugA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		5 / 11 MET A  61
PHE A 339
LEU A 296
LEU A 332
ILE A 382
 None
 1.47A 6fgcA-4iugA:
undetectable		 6fgcA-4iugA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 GLU A 855
ARG A1001
VAL A 849
PRO A 996
 None
None
NAG  A1158 ( 4.1A)
None
 1.40A 6fgdA-4iugA:
undetectable		 6fgdA-4iugA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 TYR A 727
ILE A 889
ALA A 919
ARG A 920
 None
 1.15A 6hu9m-4iugA:
undetectable
6hu9q-4iugA:
undetectable		 6hu9m-4iugA:
21.19
6hu9q-4iugA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4iug BETA-GALACTOSIDASE A
(Aspergillus
oryzae) 		4 / 6 TYR A 727
ILE A 889
ALA A 921
ARG A 920
 None
 1.08A 6hu9m-4iugA:
undetectable
6hu9q-4iugA:
undetectable		 6hu9m-4iugA:
21.19
6hu9q-4iugA:
9.24