SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		4 / 4 GLY A  69
LEU A  70
GLY A  64
ARG A  73
 None
 1.04A 1j7kA-4iukA:
undetectable		 1j7kA-4iukA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		5 / 9 ARG A  21
ILE A  20
ASN A  51
ALA A  30
LEU A 144
 None
 1.28A 3o01A-4iukA:
undetectable
3o01B-4iukA:
undetectable		 3o01A-4iukA:
22.26
3o01B-4iukA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		4 / 6 LEU A 144
GLU A  24
VAL A 107
ALA A 108
 None
 1.00A 4nkxA-4iukA:
undetectable		 4nkxA-4iukA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		5 / 12 LEU A 103
PHE A  28
ILE A 140
ALA A  68
LEU A 111
 None
None
None
NO3  A 200 (-3.7A)
None
 1.28A 5ienA-4iukA:
undetectable		 5ienA-4iukA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		5 / 12 PHE A  28
LEU A  17
ILE A 140
ALA A  68
LEU A 111
 None
None
None
NO3  A 200 (-3.7A)
None
 1.34A 5ienA-4iukA:
undetectable		 5ienA-4iukA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		5 / 12 LEU A  87
ASP A  82
SER A 135
ARG A  21
LEU A 122
 None
 1.39A 5syfB-4iukA:
undetectable		 5syfB-4iukA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		6 / 10 VAL A  71
GLY A  69
GLY A  66
LEU A 121
ILE A  97
ALA A 108
 None
None
NO3  A 200 ( 3.7A)
None
NO3  A 200 (-3.9A)
None
 1.43A 5vm8B-4iukA:
undetectable		 5vm8B-4iukA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4iuk NREA PROTEIN
(Staphylococcus
carnosus) 		3 / 3 ARG A  77
PHE A 147
PHE A 138
 None
 0.83A 6nknC-4iukA:
undetectable
6nknJ-4iukA:
undetectable		 6nknC-4iukA:
19.48
6nknJ-4iukA:
18.75