SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ius'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 VAL A  79
LEU A 103
ARG A  41
VAL A  43
 None
 0.95A 1jgsA-4iusA:
undetectable		 1jgsA-4iusA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 5 GLY A  14
GLN A  13
VAL A 182
SER A   9
 EDO  A 504 (-3.6A)
SO4  A 503 ( 3.3A)
EDO  A 504 (-4.8A)
None
 1.31A 1p6kB-4iusA:
undetectable		 1p6kB-4iusA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 4 VAL A  22
ALA A  66
LEU A  74
PHE A  67
 None
 1.21A 1q97B-4iusA:
undetectable		 1q97B-4iusA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 5 GLY A  14
GLN A  13
VAL A 182
SER A   9
 EDO  A 504 (-3.6A)
SO4  A 503 ( 3.3A)
EDO  A 504 (-4.8A)
None
 1.32A 1rs6B-4iusA:
undetectable		 1rs6B-4iusA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 5 GLY A  14
GLN A  13
VAL A 182
SER A   9
 EDO  A 504 (-3.6A)
SO4  A 503 ( 3.3A)
EDO  A 504 (-4.8A)
None
 1.33A 1zzuB-4iusA:
undetectable		 1zzuB-4iusA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 HIS A 253
TRP A  37
ASP A  33
TRP A  73
 None
 1.49A 2eijN-4iusA:
undetectable
2eijP-4iusA:
undetectable		 2eijN-4iusA:
18.80
2eijP-4iusA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.97A 3mg0H-4iusA:
undetectable
3mg0I-4iusA:
undetectable		 3mg0H-4iusA:
20.36
3mg0I-4iusA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 12 LEU A 254
TYR A 142
GLU A  77
GLY A 248
LEU A  74
 None
 1.38A 3ou6D-4iusA:
undetectable		 3ou6D-4iusA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 4 PRO A  26
LEU A  27
ILE A  63
ARG A  64
 None
 1.28A 3w1wA-4iusA:
undetectable		 3w1wA-4iusA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 5 TYR A 233
LEU A 103
ASP A 145
VAL A  98
 None
 1.30A 4nkvA-4iusA:
undetectable		 4nkvA-4iusA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qvlV-4iusA:
undetectable
4qvlb-4iusA:
undetectable		 4qvlV-4iusA:
20.20
4qvlb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qvlH-4iusA:
undetectable
4qvlN-4iusA:
undetectable		 4qvlH-4iusA:
20.20
4qvlN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.47A 4qvmV-4iusA:
undetectable
4qvmb-4iusA:
undetectable		 4qvmV-4iusA:
20.20
4qvmb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.47A 4qvmH-4iusA:
undetectable
4qvmN-4iusA:
undetectable		 4qvmH-4iusA:
20.20
4qvmN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qvpV-4iusA:
undetectable
4qvpb-4iusA:
undetectable		 4qvpV-4iusA:
20.20
4qvpb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 10 ALA A 173
THR A 172
ALA A 203
THR A 176
GLY A 159
 None
None
None
EDO  A 504 (-3.4A)
None
 0.97A 4qvpK-4iusA:
undetectable
4qvpL-4iusA:
undetectable		 4qvpK-4iusA:
21.74
4qvpL-4iusA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qvpH-4iusA:
undetectable
4qvpN-4iusA:
undetectable		 4qvpH-4iusA:
20.20
4qvpN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 10 ALA A 173
THR A 172
ALA A 203
THR A 176
GLY A 159
 None
None
None
EDO  A 504 (-3.4A)
None
 0.98A 4qvpY-4iusA:
undetectable
4qvpZ-4iusA:
undetectable		 4qvpY-4iusA:
21.74
4qvpZ-4iusA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.47A 4qvqV-4iusA:
undetectable
4qvqb-4iusA:
undetectable		 4qvqV-4iusA:
20.20
4qvqb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.47A 4qvqH-4iusA:
undetectable
4qvqN-4iusA:
undetectable		 4qvqH-4iusA:
20.20
4qvqN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.96A 4qvvH-4iusA:
undetectable		 4qvvH-4iusA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.97A 4qvvV-4iusA:
undetectable		 4qvvV-4iusA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qvwV-4iusA:
undetectable
4qvwb-4iusA:
undetectable		 4qvwV-4iusA:
20.20
4qvwb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qvwH-4iusA:
undetectable
4qvwN-4iusA:
undetectable		 4qvwH-4iusA:
20.20
4qvwN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.98A 4qvyH-4iusA:
undetectable		 4qvyH-4iusA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qw0V-4iusA:
undetectable
4qw0b-4iusA:
undetectable		 4qw0V-4iusA:
20.20
4qw0b-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 ALA A 244
THR A 243
ALA A 242
THR A 223
 None
 0.76A 4qw0K-4iusA:
undetectable		 4qw0K-4iusA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qw0H-4iusA:
undetectable
4qw0N-4iusA:
undetectable		 4qw0H-4iusA:
20.20
4qw0N-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 ALA A 244
THR A 243
ALA A 242
THR A 223
 None
 0.75A 4qw0Y-4iusA:
undetectable		 4qw0Y-4iusA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qw1V-4iusA:
undetectable
4qw1b-4iusA:
undetectable		 4qw1V-4iusA:
20.20
4qw1b-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qw1H-4iusA:
undetectable
4qw1N-4iusA:
undetectable		 4qw1H-4iusA:
20.20
4qw1N-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qw3V-4iusA:
undetectable
4qw3b-4iusA:
undetectable		 4qw3V-4iusA:
20.20
4qw3b-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qw3H-4iusA:
undetectable
4qw3N-4iusA:
undetectable		 4qw3H-4iusA:
20.20
4qw3N-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 4qwuV-4iusA:
undetectable
4qwub-4iusA:
undetectable		 4qwuV-4iusA:
20.20
4qwub-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 4qwuH-4iusA:
undetectable
4qwuN-4iusA:
undetectable		 4qwuH-4iusA:
20.20
4qwuN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 10 TYR A 233
LEU A 222
ALA A 148
ALA A 207
GLY A 187
 None
 1.35A 4rn6A-4iusA:
undetectable		 4rn6A-4iusA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 5bxnV-4iusA:
undetectable
5bxnb-4iusA:
undetectable		 5bxnV-4iusA:
20.54
5bxnb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 5bxnH-4iusA:
undetectable
5bxnN-4iusA:
undetectable		 5bxnH-4iusA:
20.54
5bxnN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.97A 5bxnV-4iusA:
undetectable
5bxnW-4iusA:
undetectable		 5bxnV-4iusA:
20.54
5bxnW-4iusA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 5cz7H-4iusA:
undetectable
5cz7N-4iusA:
undetectable		 5cz7H-4iusA:
20.20
5cz7N-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 5d0xV-4iusA:
undetectable
5d0xb-4iusA:
undetectable		 5d0xV-4iusA:
20.20
5d0xb-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.46A 5d0xH-4iusA:
undetectable
5d0xN-4iusA:
undetectable		 5d0xH-4iusA:
20.20
5d0xN-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 204
ALA A 138
GLY A 189
THR A 190
ALA A 171
 None
None
None
MLI  A 501 (-3.4A)
None
 0.97A 5d0xV-4iusA:
undetectable		 5d0xV-4iusA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 5l66V-4iusA:
undetectable
5l66b-4iusA:
undetectable		 5l66V-4iusA:
20.20
5l66b-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 11 THR A 176
THR A 183
GLY A 187
ALA A 173
THR A 172
 EDO  A 504 (-3.4A)
None
None
None
None
 1.45A 5l66H-4iusA:
undetectable
5l66N-4iusA:
undetectable		 5l66H-4iusA:
20.20
5l66N-4iusA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 5 GLY A  14
GLN A  13
VAL A 182
SER A   9
 EDO  A 504 (-3.6A)
SO4  A 503 ( 3.3A)
EDO  A 504 (-4.8A)
None
 1.37A 5vunA-4iusA:
undetectable		 5vunA-4iusA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 12 ALA A 207
GLY A 215
ALA A 203
ARG A 231
TYR A 233
 None
None
None
MLI  A 501 (-3.8A)
None
 1.28A 5zvgA-4iusA:
undetectable		 5zvgA-4iusA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		5 / 12 ALA A 207
GLY A 215
ALA A 203
ARG A 231
TYR A 233
 None
None
None
MLI  A 501 (-3.8A)
None
 1.28A 5zvgB-4iusA:
undetectable		 5zvgB-4iusA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		3 / 3 GLN A  11
TRP A 221
VAL A 182
 EDO  A 504 (-3.8A)
EDO  A 504 (-4.1A)
EDO  A 504 (-4.8A)
 0.89A 6auuA-4iusA:
undetectable		 6auuA-4iusA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ius GCN5-RELATED
N-ACETYLTRANSFERASE
(Kribbella
flavida) 		4 / 7 HIS A 253
TRP A  37
ASP A  33
TRP A  73
 None
 1.47A 6nmpN-4iusA:
undetectable
6nmpP-4iusA:
undetectable		 6nmpN-4iusA:
18.80
6nmpP-4iusA:
20.55