SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iuw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 4 ALA A 231
GLN A 412
TYR A 235
LEU A 108
 None
 1.47A 1e6wC-4iuwA:
undetectable		 1e6wC-4iuwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 10 LEU A 286
LEU A 289
ALA A 290
LEU A 276
LEU A 275
 None
 1.05A 1gwrA-4iuwA:
undetectable		 1gwrA-4iuwA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 THR A 474
HIS A 477
GLU A 478
HIS A 481
GLU A 537
 CIT  A 702 ( 4.0A)
ZN  A 701 ( 3.2A)
CIT  A 702 (-2.4A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 2.2A)
 0.38A 1j36A-4iuwA:
3.3		 1j36A-4iuwA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 THR A 474
HIS A 477
GLU A 478
HIS A 481
GLU A 537
 CIT  A 702 ( 4.0A)
ZN  A 701 ( 3.2A)
CIT  A 702 (-2.4A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 2.2A)
 0.38A 1j36B-4iuwA:
3.3		 1j36B-4iuwA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 4 ASP A 541
HIS A 477
ARG A 596
GLU A 537
 None
ZN  A 701 ( 3.2A)
CIT  A 702 (-3.0A)
ZN  A 701 ( 2.2A)
 1.00A 1lqtA-4iuwA:
undetectable		 1lqtA-4iuwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 TRP A 266
PHE A 190
TRP A 269
 None
 1.30A 1r15C-4iuwA:
undetectable		 1r15C-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 TRP A 266
PHE A 190
TRP A 269
 None
 1.29A 1r15F-4iuwA:
undetectable		 1r15F-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 TRP A 266
PHE A 190
TRP A 269
 None
 1.29A 1r15G-4iuwA:
undetectable		 1r15G-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 TRP A 266
PHE A 190
TRP A 269
 None
 1.29A 1r15H-4iuwA:
undetectable		 1r15H-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.78A 1v7zA-4iuwA:
undetectable		 1v7zA-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.78A 1v7zB-4iuwA:
undetectable		 1v7zB-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.79A 1v7zC-4iuwA:
undetectable		 1v7zC-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.81A 1v7zD-4iuwA:
undetectable		 1v7zD-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.81A 1v7zE-4iuwA:
undetectable		 1v7zE-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.80A 1v7zF-4iuwA:
undetectable		 1v7zF-4iuwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 5 PHE A 232
LEU A 115
PHE A 416
SER A 408
 None
 1.31A 1wrkB-4iuwA:
undetectable		 1wrkB-4iuwA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 5 ALA A 314
TYR A 317
ALA A  71
GLN A 410
 None
 1.12A 1xl6A-4iuwA:
undetectable
1xl6B-4iuwA:
undetectable		 1xl6A-4iuwA:
18.62
1xl6B-4iuwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 TYR A 281
CYH A 278
TYR A 317
ARG A  88
 None
 1.03A 1xqlA-4iuwA:
undetectable
1xqlB-4iuwA:
undetectable		 1xqlA-4iuwA:
21.95
1xqlB-4iuwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 TYR A 317
ARG A  88
TYR A 281
CYH A 278
 None
 1.05A 1xqlA-4iuwA:
undetectable
1xqlB-4iuwA:
undetectable		 1xqlA-4iuwA:
21.95
1xqlB-4iuwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 5 LEU A 286
LEU A 289
LEU A 276
LEU A 275
 None
 1.02A 2ab2B-4iuwA:
undetectable		 2ab2B-4iuwA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 ALA A 437
HIS A 477
GLU A 478
HIS A 481
GLU A 537
 CIT  A 702 (-4.2A)
ZN  A 701 ( 3.2A)
CIT  A 702 (-2.4A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 2.2A)
 0.31A 2c6nA-4iuwA:
3.8		 2c6nA-4iuwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 THR A 474
HIS A 477
GLU A 478
HIS A 481
 CIT  A 702 ( 4.0A)
ZN  A 701 ( 3.2A)
CIT  A 702 (-2.4A)
ZN  A 701 ( 3.4A)
 0.33A 2jihB-4iuwA:
undetectable		 2jihB-4iuwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 6 LEU A 251
MET A 105
MET A 270
LEU A 115
 None
 1.34A 2oz7A-4iuwA:
undetectable		 2oz7A-4iuwA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 SER A 482
HIS A 497
ASP A 127
 None
 0.73A 2wa2B-4iuwA:
undetectable		 2wa2B-4iuwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.78A 3a6jA-4iuwA:
undetectable		 3a6jA-4iuwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 7 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.75A 3a6jB-4iuwA:
undetectable		 3a6jB-4iuwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.76A 3a6jC-4iuwA:
undetectable		 3a6jC-4iuwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.79A 3a6jE-4iuwA:
undetectable		 3a6jE-4iuwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 GLU A 537
HIS A 477
HIS A 481
GLU A 478
 ZN  A 701 ( 2.2A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
CIT  A 702 (-2.4A)
 0.76A 3a6jF-4iuwA:
undetectable		 3a6jF-4iuwA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 6 ILE A 346
MET A 375
ILE A 446
HIS A 477
 None
None
None
ZN  A 701 ( 3.2A)
 0.92A 3eteA-4iuwA:
undetectable
3eteE-4iuwA:
undetectable		 3eteA-4iuwA:
21.68
3eteE-4iuwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 5 ILE A 346
MET A 375
ILE A 446
HIS A 477
 None
None
None
ZN  A 701 ( 3.2A)
 0.94A 3eteB-4iuwA:
undetectable
3eteC-4iuwA:
undetectable		 3eteB-4iuwA:
21.68
3eteC-4iuwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 7 MET A 375
ILE A 446
HIS A 477
ILE A 346
 None
None
ZN  A 701 ( 3.2A)
None
 0.93A 3eteD-4iuwA:
undetectable
3eteF-4iuwA:
undetectable		 3eteD-4iuwA:
21.68
3eteF-4iuwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 VAL A 173
LEU A 405
THR A 402
GLY A  81
LEU A  80
 None
 1.13A 3j6pB-4iuwA:
undetectable		 3j6pB-4iuwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 11 ALA A 223
ILE A 228
GLY A 227
LEU A 254
LEU A 258
 None
 1.19A 3kw2A-4iuwA:
undetectable		 3kw2A-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 11 ALA A 223
ILE A 228
GLY A 227
LEU A 254
LEU A 258
 None
 1.20A 3kw2B-4iuwA:
undetectable		 3kw2B-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 11 ALA A 223
ILE A 228
GLY A 227
SER A 255
LEU A 254
 None
 1.25A 3kw2B-4iuwA:
undetectable		 3kw2B-4iuwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 286
LEU A 289
ALA A 290
LEU A 276
LEU A 275
 None
 1.12A 3olsA-4iuwA:
undetectable		 3olsA-4iuwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 4 LEU A 282
GLY A  81
LEU A  80
GLU A  83
 None
 1.00A 3tgvB-4iuwA:
undetectable		 3tgvB-4iuwA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 ASP A  39
ARG A  42
THR A  38
ALA A 290
ALA A 303
 None
None
None
None
CO3  A 713 ( 4.9A)
 1.30A 3ua1A-4iuwA:
undetectable		 3ua1A-4iuwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 ILE A 452
SER A 482
PHE A 448
ILE A 346
LEU A 347
 CIT  A 702 (-4.9A)
None
None
None
None
 1.04A 3w67C-4iuwA:
undetectable		 3w67C-4iuwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 6 ILE A  89
ILE A 141
TRP A 162
TRP A 266
 None
 1.29A 3welA-4iuwA:
undetectable		 3welA-4iuwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 6 ASP A 211
ASN A 212
ALA A 245
ASP A 124
 None
 1.21A 4mdbA-4iuwA:
undetectable		 4mdbA-4iuwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 THR A 364
TRP A 499
ALA A 488
LEU A 360
PHE A 483
 None
 1.35A 4pbhA-4iuwA:
undetectable		 4pbhA-4iuwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 286
LEU A 289
ALA A 290
LEU A 276
LEU A 275
 None
 1.08A 4pxmA-4iuwA:
undetectable		 4pxmA-4iuwA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1742_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 5 ASP A 440
LYS A 443
THR A 447
ASP A 445
 None
 1.15A 5g5hC-4iuwA:
0.0		 5g5hC-4iuwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 400
HIS A 309
TRP A 306
PRO A  84
GLY A  81
 None
CO3  A 713 (-4.1A)
None
None
None
 1.21A 5nnaA-4iuwA:
undetectable		 5nnaA-4iuwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 400
HIS A 309
TRP A 306
PRO A  84
GLY A  81
 None
CO3  A 713 (-4.1A)
None
None
None
 1.21A 5nnaB-4iuwA:
undetectable		 5nnaB-4iuwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 12 LEU A 400
HIS A 309
TRP A 306
PRO A  84
GLY A  81
 None
CO3  A 713 (-4.1A)
None
None
None
 1.21A 5nnaC-4iuwA:
undetectable		 5nnaC-4iuwA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 8 ILE A 117
LEU A 251
LEU A 214
PRO A 229
 None
 1.06A 5u4sB-4iuwA:
undetectable		 5u4sB-4iuwA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		4 / 7 ARG A 577
GLU A 525
THR A 574
PRO A 592
 None
 1.47A 6a4iB-4iuwA:
undetectable		 6a4iB-4iuwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		5 / 10 ASN A  72
PHE A  68
ALA A 310
GLY A 312
ILE A 322
 None
 1.23A 6bniB-4iuwA:
undetectable		 6bniB-4iuwA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 ASP A 284
ASP A  27
ASN A  36
 None
 0.84A 6gngB-4iuwA:
undetectable		 6gngB-4iuwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4iuw NEUTRAL
ENDOPEPTIDASE
(Lactobacillus
rhamnosus) 		3 / 3 ASP A 484
ASP A 440
ASN A 131
 None
 0.82A 6gngB-4iuwA:
undetectable		 6gngB-4iuwA:
21.25