SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 253
ALA A 322
GLY A 251
LEU A 243
GLN A 244
 None
 1.22A 1qabF-4iv6A:
undetectable		 1qabF-4iv6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 362
ARG A 242
SER A 207
VAL A 205
TYR A 202
 FDA  A 401 ( 4.8A)
None
FDA  A 401 ( 3.7A)
None
None
 1.44A 1x70B-4iv6A:
undetectable		 1x70B-4iv6A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 257
VAL A 252
ALA A 355
ASP A 332
ALA A 330
 None
 1.33A 2avdB-4iv6A:
undetectable		 2avdB-4iv6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 376
LEU A 382
ASP A 383
GLU A 314
 None
 0.99A 2j2pA-4iv6A:
undetectable
2j2pB-4iv6A:
undetectable		 2j2pA-4iv6A:
20.46
2j2pB-4iv6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 165
LEU A 223
GLN A 233
LEU A 131
THR A 136
 None
 1.39A 2oaxA-4iv6A:
undetectable		 2oaxA-4iv6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 231
ALA A 176
ALA A 164
ALA A 121
MET A 134
 None
 1.32A 2x2nA-4iv6A:
undetectable		 2x2nA-4iv6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  96
GLY A  50
ALA A  61
GLY A  60
ILE A  10
 None
 0.98A 3ku1A-4iv6A:
undetectable		 3ku1A-4iv6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 362
ARG A 242
SER A 207
VAL A 205
TYR A 202
 FDA  A 401 ( 4.8A)
None
FDA  A 401 ( 3.7A)
None
None
 1.46A 4ffwA-4iv6A:
undetectable		 4ffwA-4iv6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 182
TYR A 145
THR A 100
LEU A 184
TYR A 107
 None
 1.12A 4g1bB-4iv6A:
undetectable		 4g1bB-4iv6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 182
TYR A 145
THR A 100
LEU A 184
TYR A 107
 None
 1.12A 4g1bD-4iv6A:
undetectable		 4g1bD-4iv6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 250
ALA A 322
LEU A 320
THR A 325
 None
 1.05A 5bojB-4iv6A:
undetectable		 5bojB-4iv6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 359
ASP A 332
ALA A 256
VAL A 252
GLY A 288
 None
 1.06A 5igjA-4iv6A:
undetectable		 5igjA-4iv6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		4 / 7 SER A 155
GLY A  87
ARG A 248
LEU A 357
 FDA  A 401 (-2.9A)
None
None
FDA  A 401 (-4.9A)
 0.91A 6btxA-4iv6A:
1.1		 6btxA-4iv6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
GLU A 239
LEU A 184
LEU A 162
LEU A 223
 None
 1.14A 6ew0B-4iv6A:
undetectable		 6ew0B-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
GLU A 239
LEU A 184
LEU A 162
LEU A 223
 None
 1.13A 6ew0D-4iv6A:
undetectable		 6ew0D-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0F-4iv6A:
undetectable		 6ew0F-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
GLU A 239
LEU A 184
PHE A  98
LEU A 223
 None
 0.98A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 348
ASP A 347
HIS A 337
ALA A 333
LEU A 284
 None
 1.17A 6ew0G-4iv6A:
undetectable		 6ew0G-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
GLU A 239
LEU A 184
LEU A 162
LEU A 223
 None
 1.14A 6ew0H-4iv6A:
undetectable		 6ew0H-4iv6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 4iv6 ACYL-COA
DEHYDROGENASE FADE3
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 240
GLU A 239
LEU A 184
LEU A 162
LEU A 223
 None
 1.13A 6ew0I-4iv6A:
undetectable		 6ew0I-4iv6A:
11.81