SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ILE A  84
ASP A 108
ILE A 109
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
 0.53A 1qaoA-4iv8A:
11.6		 1qaoA-4iv8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
GLY A  66
ASP A 108
ILE A 109
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
 0.53A 2b25A-4iv8A:
12.2		 2b25A-4iv8A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
GLY A  67
ASP A 108
ILE A 109
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
 0.88A 2b25A-4iv8A:
12.2		 2b25A-4iv8A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 ILE A  60
GLY A  61
GLY A  63
ALA A 127
HIS A 130
 None
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
 0.37A 2fk8A-4iv8A:
25.6		 2fk8A-4iv8A:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ASP A  83
ARG A 125
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
None
SAM  A 301 (-3.9A)
 0.89A 2gluA-4iv8A:
18.9		 2gluA-4iv8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ARG A 125
ALA A 127
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
 0.83A 2gluB-4iv8A:
18.2		 2gluB-4iv8A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  38
ASP A  59
GLY A  61
GLY A  63
GLY A  66
 None
SAM  A 301 ( 4.9A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
None
 0.70A 2oxtD-4iv8A:
8.8		 2oxtD-4iv8A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 ASP A  59
GLY A  61
ASP A  83
ILE A  84
LEU A 131
 SAM  A 301 ( 4.9A)
SAM  A 301 (-3.5A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.8A)
None
 0.74A 3cjtC-4iv8A:
13.4		 3cjtC-4iv8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
GLY A  65
ASP A 108
ILE A 109
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
 0.98A 3ihtA-4iv8A:
8.7		 3ihtA-4iv8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
ASP A  83
ASP A 108
ILE A 109
ASP A 126
 SAM  A 301 (-3.5A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
None
 1.33A 3iv6B-4iv8A:
15.0		 3iv6B-4iv8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A 188
GLN A 185
LEU A 190
PHE A 196
ALA A 201
 None
 1.13A 3kkzA-4iv8A:
22.7		 3kkzA-4iv8A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		3 / 3 GLY A  63
ASP A  83
ASP A 108
 SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.37A 3ou7C-4iv8A:
16.1		 3ou7C-4iv8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 ILE A 155
TYR A 187
ALA A 261
LEU A 153
LEU A 139
 None
 1.36A 3ozuA-4iv8A:
3.3		 3ozuA-4iv8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		6 / 12 ILE A 155
TYR A 187
GLN A 200
ALA A 261
LEU A 153
LEU A 139
 None
 1.44A 3ozwB-4iv8A:
3.2		 3ozwB-4iv8A:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
CYH A  85
ILE A 109
ARG A 125
ASP A 126
 SAM  A 301 (-3.5A)
BME  A 302 (-1.9A)
SAM  A 301 (-4.1A)
None
None
 0.83A 3uj6A-4iv8A:
35.4		 3uj6A-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		7 / 12 GLY A  61
ILE A  84
ILE A 109
ARG A 125
ASP A 126
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.1A)
None
None
SAM  A 301 (-3.9A)
None
 0.36A 3uj6A-4iv8A:
35.4		 3uj6A-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		7 / 12 GLY A  61
ILE A  84
ILE A 109
ARG A 125
ASP A 126
ALA A 127
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.1A)
None
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
 0.34A 3uj7A-4iv8A:
35.3		 3uj7A-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
CYH A  85
ARG A 125
ASP A 126
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
BME  A 302 (-1.9A)
None
None
 0.80A 3uj7B-4iv8A:
35.5		 3uj7B-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		8 / 12 GLY A  61
GLY A  63
ILE A  84
ARG A 125
ASP A 126
ALA A 127
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
None
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
None
 0.36A 3uj7B-4iv8A:
35.5		 3uj7B-4iv8A:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 11 GLY A  63
ASP A  83
ASP A 108
TYR A 158
LEU A 131
 SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
None
None
 1.00A 3v8vB-4iv8A:
12.2		 3v8vB-4iv8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  65
GLY A  67
ASP A  83
ASP A 108
 SAM  A 301 (-3.5A)
None
None
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 1.12A 4b17A-4iv8A:
11.9		 4b17A-4iv8A:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		4 / 8 TYR A 173
ARG A 177
GLY A 241
LYS A 245
 None
 0.82A 4fgzA-4iv8A:
35.9
4fgzB-4iv8A:
35.9		 4fgzA-4iv8A:
59.01
4fgzB-4iv8A:
59.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		8 / 12 GLY A  61
GLY A  63
ILE A  84
CYH A  85
ILE A 109
ARG A 125
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.9A)
None
 0.33A 4iv0A-4iv8A:
36.7		 4iv0A-4iv8A:
88.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		9 / 12 GLY A  61
GLY A  63
ILE A  84
CYH A  85
MET A  88
ASP A 108
ILE A 109
ARG A 125
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.9A)
 0.32A 4iv0B-4iv8A:
36.7		 4iv0B-4iv8A:
88.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  63
CYH A  85
MET A  88
ILE A  60
HIS A 130
 SAM  A 301 ( 3.9A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
None
SAM  A 301 (-3.9A)
 1.08A 4iv0B-4iv8A:
36.7		 4iv0B-4iv8A:
88.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		12 / 12 GLY A  61
GLY A  63
ASP A  83
ILE A  84
CYH A  85
MET A  88
ASP A 108
ILE A 109
ARG A 125
ALA A 127
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
None
 0.02A 4iv8A-4iv8A:
44.0		 4iv8A-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		6 / 12 GLY A  61
GLY A  63
ASP A  83
MET A  88
ARG A 125
LEU A 139
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
None
None
 1.04A 4iv8A-4iv8A:
44.0		 4iv8A-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		7 / 12 GLY A  63
ASP A  83
CYH A  85
MET A  88
ILE A  60
HIS A 130
LEU A 131
 SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
None
SAM  A 301 (-3.9A)
None
 1.16A 4iv8A-4iv8A:
44.0		 4iv8A-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		6 / 12 GLY A  61
GLY A  63
ASP A  83
CYH A  85
MET A  88
LEU A 129
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
None
 1.47A 4iv8B-4iv8A:
42.5		 4iv8B-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		12 / 12 GLY A  61
GLY A  63
ASP A  83
ILE A  84
CYH A  85
MET A  88
ASP A 108
ILE A 109
ARG A 125
ALA A 127
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
None
 0.09A 4iv8B-4iv8A:
42.5		 4iv8B-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		6 / 12 GLY A  61
GLY A  63
ASP A  83
MET A  88
ARG A 125
LEU A 139
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
None
None
 1.04A 4iv8B-4iv8A:
42.5		 4iv8B-4iv8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		8 / 12 GLY A  63
ASP A  83
CYH A  85
MET A  88
ILE A  60
ALA A 127
HIS A 130
LEU A 131
 SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
None
 1.17A 4iv8B-4iv8A:
42.5		 4iv8B-4iv8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		3 / 3 ARG A 125
ASP A  83
ASP A 108
 None
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.86A 4kicB-4iv8A:
14.8		 4kicB-4iv8A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ASP A 108
ARG A 125
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.5A)
None
SAM  A 301 (-3.9A)
 0.46A 4krhA-4iv8A:
32.6		 4krhA-4iv8A:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		9 / 12 GLY A  61
GLY A  63
ILE A  84
CYH A  85
MET A  88
ILE A 109
ARG A 125
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.9A)
None
 0.34A 4mwzA-4iv8A:
36.4		 4mwzA-4iv8A:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		6 / 12 GLY A  63
CYH A  85
MET A  88
ILE A  60
HIS A 130
LEU A 131
 SAM  A 301 ( 3.9A)
BME  A 302 (-1.9A)
SAM  A 301 (-3.3A)
None
SAM  A 301 (-3.9A)
None
 1.27A 4mwzA-4iv8A:
36.4		 4mwzA-4iv8A:
87.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		8 / 12 GLY A  61
GLY A  63
ILE A  84
CYH A  85
ILE A 109
ARG A 125
HIS A 130
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
BME  A 302 (-1.9A)
SAM  A 301 (-4.1A)
None
SAM  A 301 (-3.9A)
None
 0.36A 4mwzB-4iv8A:
36.5		 4mwzB-4iv8A:
87.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 ILE A  45
THR A  42
THR A 156
LEU A  46
ASP A  59
 None
None
None
None
SAM  A 301 ( 4.9A)
 1.36A 4pbhA-4iv8A:
undetectable		 4pbhA-4iv8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ILE A  84
MET A  88
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.9A)
 0.99A 4qdjA-4iv8A:
16.6		 4qdjA-4iv8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ILE A  84
MET A  88
ALA A 127
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
 0.73A 4qtuB-4iv8A:
18.4		 4qtuB-4iv8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ILE A  84
MET A  88
ALA A 127
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.8A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
 0.78A 4qtuD-4iv8A:
18.6		 4qtuD-4iv8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		4 / 4 ASP A  59
GLY A  63
ASP A  83
ASP A 108
 SAM  A 301 ( 4.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.67A 5e72A-4iv8A:
14.2		 5e72A-4iv8A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  61
GLY A  63
ASP A  83
ILE A  84
LEU A 131
 SAM  A 301 (-3.5A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.8A)
None
 0.60A 5wy0A-4iv8A:
13.5		 5wy0A-4iv8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  67
SER A  35
LEU A  64
GLY A  65
GLY A  66
 None
 0.88A 5wyqB-4iv8A:
undetectable		 5wyqB-4iv8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
knowlesi) 		5 / 12 GLY A  63
LEU A  64
GLY A  66
ASP A 108
ILE A 109
 SAM  A 301 ( 3.9A)
None
None
SAM  A 301 (-3.5A)
SAM  A 301 (-4.1A)
 0.55A 6mhtA-4iv8A:
7.7		 6mhtA-4iv8A:
20.06