SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 8 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.80A 1c9sI-4iv9A:
undetectable
1c9sJ-4iv9A:
undetectable		 1c9sI-4iv9A:
9.93
1c9sJ-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLU A  69
LEU A 281
LEU A  51
GLY A  47
PHE A 297
 FAD  A 601 (-2.8A)
None
None
FAD  A 601 (-3.6A)
None
 1.43A 1d4fA-4iv9A:
3.5		 1d4fA-4iv9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.39A 1d4fC-4iv9A:
3.6		 1d4fC-4iv9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 396
THR A 383
LEU A 411
GLY A 392
PHE A 121
 None
 1.45A 1d4fC-4iv9A:
3.6		 1d4fC-4iv9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLU A  69
LEU A 281
LEU A  51
GLY A  47
PHE A 297
 FAD  A 601 (-2.8A)
None
None
FAD  A 601 (-3.6A)
None
 1.41A 1d4fD-4iv9A:
3.6		 1d4fD-4iv9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 396
THR A 383
LEU A 411
GLY A 392
PHE A 121
 None
 1.36A 1d4fD-4iv9A:
3.6		 1d4fD-4iv9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 7 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.82A 1gtnA-4iv9A:
undetectable
1gtnK-4iv9A:
undetectable		 1gtnA-4iv9A:
9.93
1gtnK-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 8 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.79A 1gtnE-4iv9A:
undetectable
1gtnF-4iv9A:
undetectable		 1gtnE-4iv9A:
9.93
1gtnF-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A 520
GLY A  76
GLY A  47
ALA A 523
ASP A  72
 FAD  A 601 (-4.2A)
FAD  A 601 (-3.1A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.1A)
None
 1.09A 1i9gA-4iv9A:
4.0		 1i9gA-4iv9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 6 ARG A 305
SER A 530
ASN A 546
SER A 537
 None
 1.40A 1kiaC-4iv9A:
undetectable		 1kiaC-4iv9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A  95
ALA A  96
ILE A  48
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
None
None
 0.85A 1muiB-4iv9A:
undetectable		 1muiB-4iv9A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 518
ILE A 210
GLY A 238
SER A 241
ARG A  98
 FAD  A 601 ( 3.5A)
None
None
None
TSR  A 602 ( 4.3A)
 1.17A 1q8jB-4iv9A:
undetectable		 1q8jB-4iv9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 518
ILE A 210
GLY A 238
SER A 241
ILE A 239
 FAD  A 601 ( 3.5A)
None
None
None
None
 1.18A 1q8jB-4iv9A:
undetectable		 1q8jB-4iv9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 10 LEU A 256
GLY A 243
GLY A 238
VAL A 259
ILE A 255
 None
 0.92A 1sdtA-4iv9A:
undetectable		 1sdtA-4iv9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 8 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.78A 1utdI-4iv9A:
undetectable
1utdJ-4iv9A:
undetectable		 1utdI-4iv9A:
9.93
1utdJ-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		6 / 12 GLY A  95
ALA A  96
ILE A  48
GLY A  47
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
FAD  A 601 (-3.6A)
None
None
 0.97A 2avvD-4iv9A:
undetectable		 2avvD-4iv9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 7 GLU A 402
PRO A  88
ARG A  89
GLY A 405
 None
 1.27A 2hs1B-4iv9A:
undetectable		 2hs1B-4iv9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A  95
ALA A  96
ILE A  48
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
None
None
 0.90A 2q64A-4iv9A:
undetectable		 2q64A-4iv9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 10 GLY A  95
ALA A  96
ILE A  48
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
None
None
 0.93A 2r5qD-4iv9A:
undetectable		 2r5qD-4iv9A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 6 ASP A 266
TYR A 263
PHE A  99
LEU A 106
 None
None
FAD  A 601 ( 4.6A)
None
 1.08A 2w98A-4iv9A:
undetectable
2w98B-4iv9A:
undetectable		 2w98A-4iv9A:
21.70
2w98B-4iv9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 5 SER A 236
TYR A 133
PHE A 150
VAL A 153
 None
 1.22A 2x7hA-4iv9A:
2.8		 2x7hA-4iv9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 5 SER A 236
TYR A 133
PHE A 150
VAL A 153
 None
 1.18A 2x7hB-4iv9A:
2.8		 2x7hB-4iv9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 4 ARG A 257
GLY A 517
GLU A 254
SER A  49
 None
None
None
FAD  A 601 (-4.3A)
 1.39A 2xctS-4iv9A:
undetectable
2xctU-4iv9A:
undetectable		 2xctS-4iv9A:
22.77
2xctU-4iv9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A 520
GLY A  76
GLY A  47
ALA A 523
ASP A  72
 FAD  A 601 (-4.2A)
FAD  A 601 (-3.1A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.1A)
None
 1.00A 2yvlD-4iv9A:
4.2		 2yvlD-4iv9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 9 ALA A 509
GLY A  50
GLY A  47
ILE A 520
ALA A 527
 None
None
FAD  A 601 (-3.6A)
FAD  A 601 (-4.2A)
None
 0.99A 2z0yA-4iv9A:
2.8		 2z0yA-4iv9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 366
ALA A 419
LEU A 389
LEU A 435
VAL A 434
 None
 0.93A 3adxB-4iv9A:
undetectable		 3adxB-4iv9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 6 LEU A 548
LEU A 542
SER A 543
CYH A 532
 None
 0.83A 3aiaA-4iv9A:
2.0		 3aiaA-4iv9A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 GLY A  95
ALA A  96
ILE A  48
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
None
None
 0.92A 3em4U-4iv9A:
undetectable		 3em4U-4iv9A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.34A 3g1uA-4iv9A:
2.6		 3g1uA-4iv9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.37A 3g1uB-4iv9A:
2.7		 3g1uB-4iv9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 510
SER A 330
LEU A 340
ILE A 326
LEU A 360
 FAD  A 601 (-3.0A)
None
None
None
None
 1.29A 3g9eA-4iv9A:
undetectable		 3g9eA-4iv9A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.34A 3glqA-4iv9A:
2.2		 3glqA-4iv9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.39A 3glqB-4iv9A:
2.3		 3glqB-4iv9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 4 LEU A 182
ALA A 193
VAL A 173
PRO A 175
 None
 1.20A 3gv1B-4iv9A:
undetectable		 3gv1B-4iv9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 518
SER A 514
PHE A 491
ARG A 257
ASP A  11
 FAD  A 601 ( 3.5A)
None
None
None
None
 0.99A 3keeC-4iv9A:
undetectable		 3keeC-4iv9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A 518
SER A 514
PHE A 491
ARG A 257
ASP A  11
 FAD  A 601 ( 3.5A)
None
None
None
None
 0.96A 3keeD-4iv9A:
undetectable		 3keeD-4iv9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 PRO A 220
LEU A 167
VAL A 200
PHE A 252
PHE A 206
 None
 0.93A 3n23C-4iv9A:
undetectable		 3n23C-4iv9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.31A 3n58A-4iv9A:
2.1		 3n58A-4iv9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A  95
ALA A  96
ILE A  48
GLY A  75
ILE A 274
 FAD  A 601 (-3.9A)
FAD  A 601 (-3.4A)
None
None
None
 0.88A 3ndxA-4iv9A:
undetectable		 3ndxA-4iv9A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		3 / 3 LEU A 167
ARG A 202
ASN A 208
 None
 0.73A 3qxvD-4iv9A:
undetectable		 3qxvD-4iv9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 9 ALA A  42
ILE A 303
VAL A 327
GLY A  45
ILE A 312
 None
None
None
FAD  A 601 (-3.1A)
None
 1.00A 3s43A-4iv9A:
undetectable		 3s43A-4iv9A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 10 GLU A  69
GLY A  45
TYR A  68
SER A  70
SER A  49
 FAD  A 601 (-2.8A)
FAD  A 601 (-3.1A)
None
FAD  A 601 (-2.9A)
FAD  A 601 (-4.3A)
 1.48A 3s68A-4iv9A:
4.4		 3s68A-4iv9A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 508
VAL A 325
ILE A 312
GLY A 301
ILE A 337
 None
 0.95A 3so9B-4iv9A:
undetectable		 3so9B-4iv9A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 6 GLY A 222
PRO A 220
GLY A 164
TYR A 165
 None
 0.89A 4dxuA-4iv9A:
undetectable		 4dxuA-4iv9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 277
ILE A 274
ILE A  48
ALA A 523
ALA A 103
 None
None
None
FAD  A 601 (-3.1A)
None
 1.03A 4enhA-4iv9A:
undetectable		 4enhA-4iv9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 7 TYR A 507
VAL A  62
LEU A 548
LEU A 542
 None
 0.88A 4l1wA-4iv9A:
undetectable		 4l1wA-4iv9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 8 TYR A 507
VAL A  62
LEU A 548
LEU A 542
 None
 0.89A 4l1xA-4iv9A:
undetectable		 4l1xA-4iv9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 LEU A 508
VAL A 325
ILE A 312
GLY A 301
ILE A 337
 None
 0.99A 4njtA-4iv9A:
undetectable		 4njtA-4iv9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.40A 4pgfA-4iv9A:
3.6		 4pgfA-4iv9A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 GLY A 164
GLY A 156
ILE A 213
PHE A 201
PHE A 252
 None
 1.19A 4qoiA-4iv9A:
2.5
4qoiB-4iv9A:
2.5		 4qoiA-4iv9A:
18.69
4qoiB-4iv9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A 312
THR A 496
THR A 504
LEU A 347
LEU A 340
 None
 1.18A 4qynB-4iv9A:
undetectable		 4qynB-4iv9A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 GLY A  76
GLY A  75
GLY A  45
ALA A  46
ILE A 337
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-3.1A)
None
None
 0.97A 4rtmA-4iv9A:
undetectable		 4rtmA-4iv9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 LEU A 508
VAL A 325
ILE A 312
GLY A 301
ILE A 337
 None
 0.90A 4rvjA-4iv9A:
undetectable		 4rvjA-4iv9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 11 LEU A 508
VAL A 325
ILE A 312
GLY A 301
ILE A 337
 None
 0.92A 4rvjC-4iv9A:
undetectable		 4rvjC-4iv9A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 6 THR A 414
LEU A 435
ASP A 438
LEU A 411
 None
 1.02A 4wozA-4iv9A:
undetectable
4wozB-4iv9A:
undetectable		 4wozA-4iv9A:
20.57
4wozB-4iv9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A 435
ASP A 438
LEU A 411
THR A 414
 None
 1.02A 4wozF-4iv9A:
undetectable
4wozH-4iv9A:
undetectable		 4wozF-4iv9A:
20.57
4wozH-4iv9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 5 LEU A  13
TYR A 555
ALA A 193
ILE A 192
 None
 1.19A 4y03B-4iv9A:
undetectable		 4y03B-4iv9A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 ILE A 551
LEU A 542
TYR A 507
MET A 495
ALA A 497
 None
 1.50A 5fctB-4iv9A:
undetectable		 5fctB-4iv9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		3 / 3 ARG A 257
ASN A 479
ASP A 203
 None
 0.83A 5gwxA-4iv9A:
4.6		 5gwxA-4iv9A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		4 / 8 PHE A 515
GLU A 254
HIS A 359
THR A 328
 None
None
None
FAD  A 601 (-4.8A)
 1.25A 5hqaA-4iv9A:
undetectable		 5hqaA-4iv9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 THR A 120
GLN A 267
ALA A 142
GLY A 125
THR A 129
 None
 1.35A 5l5zV-4iv9A:
undetectable
5l5zW-4iv9A:
undetectable		 5l5zV-4iv9A:
18.85
5l5zW-4iv9A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 10 ASP A 438
PRO A 246
SER A 236
SER A 386
GLY A 243
 None
 1.37A 5weoA-4iv9A:
2.7
5weoD-4iv9A:
2.6		 5weoA-4iv9A:
20.34
5weoD-4iv9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_C_CYZC1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 9 PRO A 246
SER A 236
SER A 386
GLY A 243
ASP A 438
 None
 1.36A 5weoB-4iv9A:
0.0
5weoC-4iv9A:
0.0		 5weoB-4iv9A:
20.34
5weoC-4iv9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.36A 6aphA-4iv9A:
2.3		 6aphA-4iv9A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4iv9 TRYPTOPHAN
2-MONOOXYGENASE
(Pseudomonas
savastanoi) 		5 / 12 LEU A 281
LEU A 528
GLY A 105
HIS A 108
PHE A 113
 None
 1.35A 6gbnB-4iv9A:
undetectable		 6gbnB-4iv9A:
22.55