SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ivi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 LEU A 245
PHE A 256
MET A 298
SER A 300
 None
 1.15A 1wrkB-4iviA:
undetectable		 1wrkB-4iviA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 VAL A 135
ASN A 134
VAL A 154
ILE A 158
 None
 1.07A 1z2bC-4iviA:
undetectable		 1z2bC-4iviA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 GLY A 297
GLN A 296
TRP A 291
SER A 102
 None
 1.32A 1zzuA-4iviA:
undetectable		 1zzuA-4iviA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 VAL A 232
LEU A 119
VAL A 114
GLY A 226
LEU A 246
 None
 1.06A 2cbrA-4iviA:
undetectable		 2cbrA-4iviA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 8 GLY A 295
GLY A 294
TRP A 291
PHE A 199
HIS A 220
 None
 1.29A 2ha4A-4iviA:
undetectable		 2ha4A-4iviA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 ALA A 347
TYR A 348
ASP A 217
TYR A 210
 None
 1.28A 2pncA-4iviA:
undetectable		 2pncA-4iviA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 6 PHE A 190
GLY A 295
GLY A 294
ASN A 196
 None
 0.89A 2qr2A-4iviA:
undetectable
2qr2B-4iviA:
undetectable		 2qr2A-4iviA:
22.14
2qr2B-4iviA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 MET A 271
ALA A  63
THR A  59
ARG A  97
GLY A 386
 None
 1.44A 3aobC-4iviA:
undetectable		 3aobC-4iviA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 PHE A  76
PHE A 361
PHE A 308
GLY A 360
ILE A  98
 None
 1.45A 3ld6B-4iviA:
undetectable		 3ld6B-4iviA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 ASP A 223
ILE A 203
GLY A 173
PRO A 207
ILE A 170
 None
 0.98A 3s45A-4iviA:
undetectable		 3s45A-4iviA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 6 TYR A 218
ASP A 223
GLN A 296
GLU A 241
 None
 1.09A 4azvA-4iviA:
undetectable		 4azvA-4iviA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		3 / 3 ARG A  97
GLU A 281
ARG A 286
 None
 0.95A 4mwvA-4iviA:
undetectable		 4mwvA-4iviA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		3 / 3 ASP A 217
TYR A 210
TRP A 216
 None
 1.29A 4p7nA-4iviA:
undetectable		 4p7nA-4iviA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		3 / 3 GLY A 152
PRO A 153
GLN A 211
 None
 0.57A 4qwpB-4iviA:
undetectable		 4qwpB-4iviA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 THR A 159
ILE A 224
VAL A 209
LEU A 208
PHE A 132
 None
 1.29A 4r38C-4iviA:
undetectable		 4r38C-4iviA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 ALA A 110
SER A 221
GLY A 360
PHE A 361
GLY A 333
 None
 0.76A 4rzvA-4iviA:
undetectable		 4rzvA-4iviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 ALA A 110
SER A 221
GLY A 360
PHE A 361
GLY A 333
 None
 0.81A 4rzvB-4iviA:
undetectable		 4rzvB-4iviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 VAL A 376
TYR A 218
ILE A 170
THR A 106
 None
 1.29A 4ze1A-4iviA:
undetectable		 4ze1A-4iviA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 VAL A 412
TYR A 172
ILE A 170
THR A 106
 None
 1.33A 4ze1A-4iviA:
undetectable		 4ze1A-4iviA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 11 PHE A 283
GLY A 295
GLY A 294
ASN A 196
ILE A 105
 None
 1.27A 4zvmA-4iviA:
undetectable
4zvmB-4iviA:
undetectable		 4zvmA-4iviA:
22.14
4zvmB-4iviA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 LEU A 113
LEU A 119
MET A 332
TYR A 323
 None
 1.09A 5uc3A-4iviA:
undetectable		 5uc3A-4iviA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_A_9KLA402_0
(EST-Y29)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		6 / 12 TYR A  99
LYS A 103
TYR A 172
TYR A 218
GLY A 383
ALA A 384
 None
 0.36A 5zwrA-4iviA:
48.1		 5zwrA-4iviA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_B_9KLB402_0
(EST-Y29)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		6 / 12 TYR A  99
SER A 100
LYS A 103
TYR A 172
TYR A 218
ALA A 384
 None
 0.37A 5zwrB-4iviA:
48.0		 5zwrB-4iviA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_B_9KLB402_0
(EST-Y29)		 4ivi CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 TYR A  99
SER A 100
LYS A 103
TYR A 218
ALA A 384
 None
 1.32A 5zwrB-4iviA:
48.0		 5zwrB-4iviA:
30.22