SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ivn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 5 PHE A 159
GLY A 131
SER A 172
PHE A 129
 None
 1.21A 1icuC-4ivnA:
undetectable
1icuD-4ivnA:
undetectable		 1icuC-4ivnA:
21.48
1icuD-4ivnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 5 PHE A 159
GLY A 131
SER A 172
PHE A 129
 None
 1.12A 1icvA-4ivnA:
undetectable
1icvB-4ivnA:
undetectable		 1icvA-4ivnA:
21.48
1icvB-4ivnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 LEU A 207
ALA A 225
LEU A 223
THR A 108
 None
 1.16A 1tyrA-4ivnA:
undetectable		 1tyrA-4ivnA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 MET A  15
LEU A   7
PHE A  70
MET A  62
 None
 1.19A 1x8vA-4ivnA:
undetectable		 1x8vA-4ivnA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 LEU A  44
GLN A  37
TYR A  28
PHE A  70
LEU A  11
 None
 1.28A 3gwuA-4ivnA:
undetectable		 3gwuA-4ivnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 ILE A 157
GLY A 131
ALA A 197
ALA A 127
ILE A 133
 None
 0.93A 3jb1A-4ivnA:
undetectable		 3jb1A-4ivnA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 9 ALA A 180
GLY A 131
ILE A 130
PRO A 203
THR A 220
 None
 1.29A 3spkA-4ivnA:
undetectable		 3spkA-4ivnA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 LEU A 207
ALA A 225
LEU A 223
THR A 108
 None
 1.22A 4d7bB-4ivnA:
undetectable		 4d7bB-4ivnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 12 ASP A  27
ARG A  10
PRO A  17
ASN A  14
ARG A  23
 None
 1.45A 4kmuH-4ivnA:
undetectable		 4kmuH-4ivnA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 10 LEU A   8
LEU A  30
ALA A  33
LEU A  58
LEU A  74
 None
 1.17A 4p65A-4ivnA:
undetectable
4p65B-4ivnA:
undetectable
4p65F-4ivnA:
undetectable
4p65H-4ivnA:
undetectable		 4p65A-4ivnA:
5.78
4p65B-4ivnA:
8.05
4p65F-4ivnA:
8.05
4p65H-4ivnA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 11 LEU A   8
LEU A  30
ALA A  33
LEU A  74
LEU A  58
 None
 1.14A 4p65C-4ivnA:
undetectable
4p65D-4ivnA:
undetectable
4p65J-4ivnA:
undetectable
4p65L-4ivnA:
undetectable		 4p65C-4ivnA:
5.78
4p65D-4ivnA:
8.05
4p65J-4ivnA:
8.05
4p65L-4ivnA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 9 ILE A 140
VAL A 141
GLY A 235
ALA A 236
SER A 104
 None
None
BMX  A1000 ( 4.7A)
None
None
 0.92A 4r21B-4ivnA:
undetectable		 4r21B-4ivnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 9 ALA A 127
PHE A 129
TRP A 178
VAL A 204
VAL A 205
 None
 1.38A 4z69A-4ivnA:
undetectable		 4z69A-4ivnA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 LEU A 207
ALA A 225
LEU A 223
THR A 108
 None
 1.18A 5l4iB-4ivnA:
undetectable		 5l4iB-4ivnA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 10 ILE A 120
LEU A 117
ASN A 209
LEU A 245
ALA A 243
 None
 1.14A 5y7pD-4ivnA:
undetectable		 5y7pD-4ivnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 10 ILE A 120
LEU A 117
ASN A 209
LEU A 245
ALA A 243
 None
 1.18A 5y7pH-4ivnA:
undetectable		 5y7pH-4ivnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 SER A 239
ALA A 137
SER A 138
ALA A 236
 None
BMX  A1000 (-3.4A)
BMX  A1000 (-2.6A)
None
 0.83A 6bocA-4ivnA:
undetectable
6bocB-4ivnA:
undetectable
6bocC-4ivnA:
undetectable
6bocD-4ivnA:
undetectable		 6bocA-4ivnA:
5.98
6bocB-4ivnA:
5.98
6bocC-4ivnA:
5.98
6bocD-4ivnA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4ivn TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		3 / 3 PHE A  38
ARG A  71
GLN A  37
 None
 1.02A 6g1pB-4ivnA:
undetectable		 6g1pB-4ivnA:
22.04