SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
6 / 9 ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.58A 1bcuH-4iw4E:
34.0
1bcuH-4iw4E:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 9 HIS E 478
ASP E 639
SER E 645
TRP E 667
GLY E 680
None
0.70A 1dwcH-4iw4E:
33.0
1dwcH-4iw4E:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
7 / 12 HIS E 478
ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.70A 1etrH-4iw4E:
32.7
1etrH-4iw4E:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 8 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.35A 1f5lA-4iw4E:
32.5
1f5lA-4iw4E:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
4 / 8 ASP E 534
PHE E 526
SER E 645
ALA E 536
None
1.11A 1rqpC-4iw4E:
undetectable
1rqpC-4iw4E:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
4 / 8 ASP E 534
PHE E 526
SER E 645
ALA E 536
None
1.10A 1rqpA-4iw4E:
undetectable
1rqpA-4iw4E:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 6 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.42A 1tnlA-4iw4E:
33.7
1tnlA-4iw4E:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
4 / 8 VAL E 497
VAL E 450
LEU E 480
TRP E 461
None
0.78A 2gehA-4iw4E:
undetectable
2gehA-4iw4E:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 6 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.50A 2otvA-4iw4E:
33.7
2otvA-4iw4E:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
7 / 12 ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
TYR E 682
None
0.51A 2p16A-4iw4E:
32.0
2p16A-4iw4E:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
7 / 12 TYR E 531
ASP E 639
VAL E 665
TRP E 667
GLY E 668
GLY E 680
TYR E 682
None
0.76A 2p16A-4iw4E:
32.0
2p16A-4iw4E:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
4 / 8 ASP E 534
PHE E 526
SER E 645
ALA E 536
None
1.11A 2v7uA-4iw4E:
undetectable
2v7uA-4iw4E:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 8 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.39A 2vinA-4iw4E:
33.0
2vinA-4iw4E:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
8 / 12 ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 669
GLY E 680
TYR E 682
None
0.75A 2w26A-4iw4E:
32.0
2w26A-4iw4E:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
8 / 12 TYR E 531
ASP E 639
VAL E 665
TRP E 667
GLY E 668
GLY E 669
GLY E 680
TYR E 682
None
0.94A 2w26A-4iw4E:
32.0
2w26A-4iw4E:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 VAL E 497
ILE E 448
VAL E 450
LEU E 480
TRP E 461
None
1.03A 3fw3B-4iw4E:
undetectable
3fw3B-4iw4E:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
6 / 11 HIS E 478
ASP E 639
SER E 645
TRP E 667
GLY E 668
GLY E 680
None
0.58A 3gy3A-4iw4E:
32.9
3gy3A-4iw4E:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 VAL E 499
SER E 515
ALA E 512
GLY E 502
LEU E 467
None
1.07A 3ln1D-4iw4E:
undetectable
3ln1D-4iw4E:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 11 LEU E 568
TYR E 633
VAL E 605
GLY E 632
ALA E 631
None
1.19A 3pghB-4iw4E:
undetectable
3pghB-4iw4E:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 6 SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.34A 3rxfA-4iw4E:
13.7
3rxfA-4iw4E:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
4 / 5 ASP E 639
SER E 645
VAL E 665
GLY E 680
None
0.44A 3rxhA-4iw4E:
33.9
3rxhA-4iw4E:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 HIS E 478
ASP E 639
VAL E 665
TRP E 667
GLY E 680
None
0.59A 4hfpD-4iw4E:
32.9
4hfpD-4iw4E:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 LEU E 568
GLY E 569
VAL E 606
THR E 640
VAL E 665
None
1.14A 4ok1A-4iw4E:
undetectable
4ok1A-4iw4E:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 LEU E 568
GLY E 569
VAL E 606
THR E 640
VAL E 665
None
1.19A 4okwA-4iw4E:
undetectable
4okwA-4iw4E:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 LEU E 568
GLY E 569
VAL E 606
THR E 640
VAL E 665
None
1.21A 4okxA-4iw4E:
undetectable
4okxA-4iw4E:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
6 / 10 ALA E 476
THR E 475
ALA E 536
ALA E 477
GLY E 663
THR E 683
None
1.49A 4qvyK-4iw4E:
undetectable
4qvyL-4iw4E:
undetectable
4qvyK-4iw4E:
22.19
4qvyL-4iw4E:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
6 / 10 ALA E 476
THR E 475
ALA E 536
ALA E 477
GLY E 663
THR E 683
None
1.49A 4qvyY-4iw4E:
undetectable
4qvyZ-4iw4E:
undetectable
4qvyY-4iw4E:
22.19
4qvyZ-4iw4E:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 HIS E 478
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.34A 4rn6B-4iw4E:
28.9
4rn6B-4iw4E:
31.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 VAL E 499
SER E 515
ALA E 512
GLY E 502
LEU E 467
None
1.08A 5kirB-4iw4E:
undetectable
5kirB-4iw4E:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 GLY E 647
TYR E 600
ILE E 448
ALA E 476
ASP E 644
None
1.21A 5kvaA-4iw4E:
undetectable
5kvaA-4iw4E:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
5 / 12 GLY E 647
TYR E 600
ILE E 448
ALA E 476
ASP E 644
None
1.21A 5kvaB-4iw4E:
undetectable
5kvaB-4iw4E:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo
sapiens)
3 / 3 SER E 666
SER E 645
PHE E 526
None
0.82A 5mugA-4iw4E:
undetectable
5mugA-4iw4E:
21.81