SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  40
LEU A  38
ASN A 273
LEU A 277
GLN A 278
 None
 1.41A 1a28B-4iw7A:
undetectable		 1a28B-4iw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 8 HIS A 121
SER A 163
HIS A 188
LYS A 220
ARG A 344
 None
 1.04A 1eqbA-4iw7A:
27.2
1eqbB-4iw7A:
27.2		 1eqbA-4iw7A:
22.51
1eqbB-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A  35
SER A 163
HIS A 188
LYS A 220
 None
 1.13A 1eqbA-4iw7A:
27.2
1eqbB-4iw7A:
27.2		 1eqbA-4iw7A:
22.51
1eqbB-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 8 HIS A 121
SER A 163
HIS A 188
LYS A 220
ARG A 344
 None
 1.03A 1eqbA-4iw7A:
27.2
1eqbB-4iw7A:
27.3		 1eqbA-4iw7A:
22.51
1eqbB-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A  35
SER A 163
HIS A 188
LYS A 220
 None
 1.12A 1eqbA-4iw7A:
27.2
1eqbB-4iw7A:
27.3		 1eqbA-4iw7A:
22.51
1eqbB-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 8 HIS A 121
SER A 163
HIS A 188
LYS A 220
ARG A 344
 None
 1.03A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A  35
SER A 163
HIS A 188
LYS A 220
 None
 1.13A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 8 HIS A 121
SER A 163
HIS A 188
LYS A 220
ARG A 344
 None
 1.03A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A  35
SER A 163
HIS A 188
LYS A 220
 None
 1.12A 1eqbC-4iw7A:
27.3
1eqbD-4iw7A:
27.3		 1eqbC-4iw7A:
22.51
1eqbD-4iw7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A 103
VAL A 215
ASP A 185
ALA A 175
TYR A 104
 None
 1.22A 1kiaB-4iw7A:
3.0		 1kiaB-4iw7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 5 VAL A 161
SER A 189
ASP A 172
GLN A 141
 None
 1.49A 1n2xB-4iw7A:
3.7		 1n2xB-4iw7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A 103
VAL A 215
ASP A 185
ALA A 175
TYR A 104
 None
 1.21A 1nbhC-4iw7A:
undetectable		 1nbhC-4iw7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 11 SER A 297
PHE A 284
PHE A 204
LEU A 193
VAL A 192
 None
 1.35A 1q23G-4iw7A:
undetectable		 1q23G-4iw7A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 7 HIS A 188
TYR A  37
ASN A 351
LEU A 277
 None
 0.96A 1qzrA-4iw7A:
undetectable		 1qzrA-4iw7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 11 GLY A 199
ILE A 206
ALA A 175
THR A 178
VAL A 184
 None
 1.10A 2nnhA-4iw7A:
undetectable		 2nnhA-4iw7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 HIS A 121
SER A 163
HIS A 188
LYS A 220
 None
 0.83A 2vmyA-4iw7A:
27.4
2vmyB-4iw7A:
27.3		 2vmyA-4iw7A:
22.37
2vmyB-4iw7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 HIS A 121
SER A 163
LYS A 220
ARG A 344
 None
 0.94A 2vmyA-4iw7A:
27.4
2vmyB-4iw7A:
27.3		 2vmyA-4iw7A:
22.37
2vmyB-4iw7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 SER A  35
HIS A 121
SER A 163
LYS A 220
 None
 1.04A 2vmyA-4iw7A:
27.4
2vmyB-4iw7A:
27.3		 2vmyA-4iw7A:
22.37
2vmyB-4iw7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 10 ILE A 306
ALA A 314
ILE A 363
ILE A 326
PHE A 345
 None
 1.15A 2w9sC-4iw7A:
undetectable		 2w9sC-4iw7A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		3 / 3 ARG A 274
ASP A  36
ASN A 273
 None
 0.79A 2zzmA-4iw7A:
2.2		 2zzmA-4iw7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 6 ARG A 198
PHE A  81
PHE A 190
PHE A 222
 None
 1.49A 3af3A-4iw7A:
1.9		 3af3A-4iw7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 4 ILE A 149
THR A 178
LYS A 181
TYR A 138
 None
 1.34A 3elzA-4iw7A:
0.0		 3elzA-4iw7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 TYR A  37
LEU A  38
ILE A 356
LEU A 277
ILE A 281
 None
 1.10A 3ijdB-4iw7A:
undetectable		 3ijdB-4iw7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 ASP A 299
SER A 297
PHE A 162
LEU A 174
 None
 0.94A 3m0wE-4iw7A:
undetectable
3m0wF-4iw7A:
undetectable
3m0wG-4iw7A:
undetectable
3m0wH-4iw7A:
undetectable		 3m0wE-4iw7A:
15.32
3m0wF-4iw7A:
15.32
3m0wG-4iw7A:
15.32
3m0wH-4iw7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 5 LEU A 218
GLY A 226
PHE A  92
PHE A  77
 None
 0.99A 3smtA-4iw7A:
undetectable		 3smtA-4iw7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 PHE A  93
GLY A 226
ALA A 227
ALA A 187
SER A  35
 None
 1.09A 3sudB-4iw7A:
undetectable		 3sudB-4iw7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		3 / 3 SER A  41
GLY A 223
GLN A 263
 None
 0.59A 3v4tH-4iw7A:
undetectable		 3v4tH-4iw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 LEU A  40
LEU A  38
ASN A 273
LEU A 277
GLN A 278
 None
 1.33A 3zqtA-4iw7A:
undetectable		 3zqtA-4iw7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A  50
GLY A  53
ALA A 259
PHE A  92
LEU A  46
 None
 1.25A 5hw4A-4iw7A:
undetectable		 5hw4A-4iw7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 11 ILE A  50
GLY A  53
ALA A 259
PHE A  92
LEU A  46
 None
 1.22A 5hw4B-4iw7A:
undetectable		 5hw4B-4iw7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 12 ILE A  50
GLY A  53
ALA A 259
PHE A  92
LEU A  46
 None
 1.20A 5hw4C-4iw7A:
undetectable		 5hw4C-4iw7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		4 / 8 TYR A 119
ILE A 342
VAL A 296
ILE A 303
 None
 0.95A 5mzrE-4iw7A:
undetectable		 5mzrE-4iw7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		5 / 11 PRO A 217
ASP A 185
SER A 123
LEU A 107
THR A 106
 None
 1.42A 5tiyA-4iw7A:
undetectable		 5tiyA-4iw7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE
(Francisella
tularensis) 		3 / 3 HIS A 188
ARG A 344
ILE A 303
 None
 0.71A 6fgdA-4iw7A:
undetectable		 6fgdA-4iw7A:
21.64