SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iw9 GLUTATHIONE
TRANSFERASE
(Mannheimia
haemolytica) 		4 / 7 LEU A 165
PHE A 100
PHE A 154
LEU A 185
 None
 0.86A 1wrlE-4iw9A:
undetectable
1wrlF-4iw9A:
undetectable		 1wrlE-4iw9A:
15.72
1wrlF-4iw9A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4iw9 GLUTATHIONE
TRANSFERASE
(Mannheimia
haemolytica) 		3 / 3 TRP A  20
ALA A 194
VAL A 198
 None
 0.76A 2izqA-4iw9A:
undetectable
2izqB-4iw9A:
undetectable		 2izqA-4iw9A:
5.43
2izqB-4iw9A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4iw9 GLUTATHIONE
TRANSFERASE
(Mannheimia
haemolytica) 		3 / 3 ALA A 194
VAL A 198
TRP A  20
 None
 0.78A 3l8lA-4iw9A:
undetectable
3l8lB-4iw9A:
undetectable		 3l8lA-4iw9A:
5.43
3l8lB-4iw9A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4iw9 GLUTATHIONE
TRANSFERASE
(Mannheimia
haemolytica) 		5 / 12 GLY A 206
LEU A 207
TYR A  29
VAL A 160
GLY A   8
 None
 1.19A 5hg0A-4iw9A:
undetectable		 5hg0A-4iw9A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4iw9 GLUTATHIONE
TRANSFERASE
(Mannheimia
haemolytica) 		4 / 6 MET A 168
ALA A  99
LEU A  98
ALA A 161
 None
 1.19A 6fosB-4iw9A:
undetectable		 6fosB-4iw9A:
18.57