SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4iwb FLIC, FLIS CHIMERA
(Aquifex
aeolicus) 		4 / 7 TYR A  66
VAL A  99
TYR A 126
ILE A 146
 None
 1.35A 2xz5B-4iwbA:
undetectable
2xz5E-4iwbA:
undetectable		 2xz5B-4iwbA:
18.43
2xz5E-4iwbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4iwb FLIC, FLIS CHIMERA
(Aquifex
aeolicus) 		4 / 6 ASN A  95
GLU A  71
GLU A  74
GLU A  78
 None
 1.38A 4mi4A-4iwbA:
undetectable		 4mi4A-4iwbA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4iwb FLIC, FLIS CHIMERA
(Aquifex
aeolicus) 		3 / 3 PRO A  58
LEU A  59
GLN A  30
 None
 0.69A 4pevB-4iwbA:
undetectable		 4pevB-4iwbA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4iwb FLIC, FLIS CHIMERA
(Aquifex
aeolicus) 		4 / 7 ASN A  95
GLU A  71
GLU A  74
GLU A  78
 None
 1.32A 4r87I-4iwbA:
undetectable		 4r87I-4iwbA:
24.35